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| ID | Type | Description | Link |
|---|---|---|---|
| CV OUTCOMES 1 | |||
| 2013-002646-36 | EudraCT Number | ||
| CV OUTCOMES 2 | Other Identifier | Alias Study Number |
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See Detailed Description
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This study evaluates the PCSK9 inhibitor, Bococizumab (PF-04950615;RN316), compared to placebo, in reducing the occurrence of major cardiovascular events, including cardiovascular death, myocardial infarction, stroke, and unstable angina requiring urgent revascularization, in high risk subjects who are receiving background lipid lowering therapy and have cholesterol laboratory values of LDL-C >/= 70 mg/dL (1.8 mmol/L) or non-HDL-C >/= 100 mg /dL (2.6 mmol/L).
The trial was terminated prematurely on November 1, 2016, due to the emerging clinical profile and the evolving treatment and market landscape for lipid-lowering agents. These indicated that bococizumab was not likely to provide value to patients, physicians, or shareholders. The decision was not based on a recommendation by the independent Data Monitoring Committee to stop the program.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| bococizumab (PF-04950615) | Experimental | 150 mg, every 2 weeks, subcutaneous |
|
| Placebo | Placebo Comparator | Placebo comparator, every 2 weeks, subcutaneous. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| bococizumab (PF-04950615) | Drug | 150 mg, every 2 weeks, subcutaneous. The duration of the treatment period will depend upon reaching the targeted number of adjudicated and confirmed CV outcome events, approximately 3 to 4 years after the entry of first subject into the study. |
| Measure | Description | Time Frame |
|---|---|---|
| Event Rate Per 100 Participant-Years For First Occurrence of Major Cardiovascular (CV) Event | Event rate per 100 participant-years for first occurrence of major CV event (adjudicated by Adjudication Committee) was reported. Major CV event was defined as any of the following: CV death (defined as sudden cardiac death, fatal myocardial infarction [MI], death due to heart failure, death due to stroke [fatal ischemic stroke or fatal stroke of undetermined etiology], or death due to other cardiovascular causes) non-fatal MI, non-fatal stroke, and hospitalization for unstable angina needing urgent revascularization. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of major CV event (maximum duration: up to 3.4 years) |
| Measure | Description | Time Frame |
|---|---|---|
| Event Rate Per 100 Participant-Years For First Occurrence of Composite Endpoint of Cardiovascular Death, Non-Fatal Myocardial Infraction, or Non-Fatal Stroke | Event rate per 100 participant-years for first occurrence of composite endpoint of CV death, non-fatal MI or non-fatal stroke (adjudicated by Adjudication Committee) was reported. Cardiovascular death was defined as sudden cardiac death, fatal MI, death due to heart failure, death due to stroke (fatal ischemic stroke or fatal stroke of undetermined etiology), or death due to other cardiovascular causes. Event rate was calculated as the number of events per 100 participant-years at risk. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pfizer CT.gov Call Center | Pfizer | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ernest Hendrix, MD, PC | Athens | Alabama | 35611 | United States | ||
| North Alabama Research Center LLC |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35277540 | Derived | Chasman DI, Hyde CL, Giulianini F, Danning RD, Wang EQ, Hickling T, Ridker PM, Loomis AK. Genome-wide pharmacogenetics of anti-drug antibody response to bococizumab highlights key residues in HLA DRB1 and DQB1. Sci Rep. 2022 Mar 11;12(1):4266. doi: 10.1038/s41598-022-07997-5. | |
| 29716940 | Derived | Pradhan AD, Aday AW, Rose LM, Ridker PM. Residual Inflammatory Risk on Treatment With PCSK9 Inhibition and Statin Therapy. Circulation. 2018 Jul 10;138(2):141-149. doi: 10.1161/CIRCULATIONAHA.118.034645. Epub 2018 May 1. |
| Label | URL |
|---|---|
| To obtain contact information for a study center near you, click here. | View source |
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| ID | Title | Description |
|---|---|---|
| FG000 | Placebo | Participants received single dose of placebo matched to PF-04950615 subcutaneous injection once every 2 weeks for upto 3 years. Participants were followed up to 40 days after the last dose. |
| FG001 | Bococizumab (PF-04950615) |
| Title | Milestones | Reasons Not Completed | |||||
|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Feb 12, 2016 | Mar 14, 2018 |
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|
| Placebo | Drug | Placebo comparator, every 2 weeks, subcutaneous. The duration of the treatment period will depend upon reaching the targeted number of adjudicated and confirmed CV outcome events, approximately 3 to 4 years after the entry of first subject into the study. |
|
| From baseline until the date of first adjudicated and confirmed occurrence of the CV death, non-fatal MI or non-fatal stroke (maximum duration: up to 3.4 years) |
| Event Rate Per 100 Participant-Years For First Occurrence of Composite Endpoint of All-Cause Death, Non-Fatal Myocardial Infraction, Non-Fatal Stroke, or Hospitalization for Unstable Angina Needing Urgent Revascularization | Event rate per 100 participant-years for first occurrence of composite endpoint of all-cause death, non-fatal MI, non-fatal stroke, or hospitalization for unstable angina needing urgent revascularization (adjudicated by Adjudication Committee) was reported. All-cause death was defined as the death due to any cause during the course of study. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of all-cause death, non-fatal MI, non-fatal stroke, or hospitalization for unstable angina needing urgent revascularization (maximum duration: up to 3.4 years) |
| Event Rate Per 100 Participant-Years For First Occurrence of Composite Endpoint of All-Cause Death, Non-Fatal Myocardial Infarction, or Non-Fatal Stroke | Event rate per 100 participant-years for first occurrence of composite endpoint of all-cause death, non-fatal MI, or non-fatal stroke (adjudicated by adjudication committee) was reported. All-cause death was defined as the death due to any cause during the course of study. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of the all-cause death, non-fatal MI, or non-fatal stroke (maximum duration: up to 3.4 years) |
| Event Rate Per 100 Participant-Years For First Occurrence of Hospitalization for Unstable Angina Needing Urgent Revascularization | Event rate per 100 participant-years for first occurrence of hospitalization for unstable angina needing urgent revascularization (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of hospitalization for unstable angina needing urgent revascularization (maximum duration: up to 3.4 years) |
| Event Rate Per 100 Participant-Years For First Occurrence of Composite Endpoint of Cardiovascular Death, Non-Fatal Myocardial Infarction, Non-Fatal Stroke and Hospitalization for Unstable Angina | Event rate per 100 participant-years for first occurrence of composite endpoint of cardiovascular death, non-fatal MI, non-fatal stroke and hospitalization for unstable angina (adjudicated by adjudication committee) was reported. Cardiovascular death was defined as sudden cardiac death, fatal MI, death due to heart failure, death due to stroke (fatal ischemic stroke or fatal stroke of undetermined etiology), or death due to other cardiovascular causes. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of cardiovascular death, non-fatal MI, non-fatal stroke and hospitalization for unstable angina (maximum duration: up to 3.4 years) |
| Event Rate Per 100 Participant-Years For Cardiovascular Death | Event rate per 100 participant-years for cardiovascular death (adjudicated by adjudication committee) was reported. Cardiovascular death was defined as sudden cardiac death, fatal MI, death due to heart failure, death due to stroke (fatal ischemic stroke or fatal stroke of undetermined etiology), or death due to other cardiovascular causes. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of adjudicated and confirmed occurrence of cardiovascular death (maximum duration: up to 3.4 years) |
| Event Rate Per 100 Participant-Years For First Occurrence of Any Myocardial Infarction (Fatal or Non-Fatal) | Event rate per 100 participant-years for first occurrence of any MI (fatal or non-fatal) (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of any MI (fatal or non-fatal) (maximum duration: up to 3.4 years) |
| Event Rate Per 100 Participant-Years For Fatal Myocardial Infarction | Event rate per 100 participant-years for fatal MI (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of adjudicated and confirmed occurrence of fatal MI (maximum duration: up to 3.4 years) |
| Event Rate Per 100 Participant-Years For First Occurrence of Non-Fatal Myocardial Infarction | Event rate per 100 participant-years for first occurrence of non-fatal MI (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of non-fatal MI (maximum duration: up to 3.4 years) |
| Event Rate Per 100 Participant-Years For First Occurrence of Any Stroke (Fatal or Non-Fatal) | Event rate per 100 participant-years for first occurrence of any stroke (fatal or non-fatal) (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of any stroke (fatal or non-fatal) (maximum duration: up to 3.4 years) |
| Event Rate Per 100 Participant-Years For First Occurrence of Any Stroke (Fatal or Non-Fatal), of Any Etiology | Event rate per 100 participant-years for first occurrence of any stroke (fatal or non-fatal), of any etiology (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of any stroke (fatal or non-fatal), of any etiology (maximum duration: up to 3.4 years) |
| Event Rate Per 100 Participant-Years For Fatal Stroke | Event rate per 100 participant-years for fatal stroke (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of fatal stroke (maximum duration: up to 3.4 years) |
| Event Rate Per 100 Participant-Years For First Occurrence of Non-Fatal Stroke | Event rate per 100 participant-years for first occurrence of non-fatal stroke (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of non-fatal stroke (maximum duration: up to 3.4 years) |
| Event Rate Per 100 Participant-Years For First Occurrence of Hospitalization for Unstable Angina | Event rate per 100 participant-years for first occurrence of hospitalization for unstable angina (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of hospitalization for unstable angina (maximum duration: up to 3.4 years) |
| Event Rate Per 100 Participant-Years For First Occurrence of Hospitalization for Congestive Heart Failure (CHF) | Event rate per 100 participant-years for first occurrence of hospitalization for CHF (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of hospitalization for congestive heart failure (maximum duration: up to 3.4 years) |
| Event Rate Per 100 Participant-Years For First Occurrence of Coronary Revascularization | Event rate per 100 participant-years for first occurrence of coronary revascularization (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of coronary revascularization (maximum duration: up to 3.4 years) |
| Event Rate Per 100 Participant-Years For First Occurrence of Coronary Artery Bypass Graft Surgery (CABG) | Event rate per 100 participant-years for first occurrence of CABG (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of CABG (maximum duration: up to 3.4 years) |
| Event Rate Per 100 Participant-Years For First Occurrence of Percutaneous Coronary Intervention (PCI) | Event rate per 100 participant-years for first occurrence of PCI (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of PCI (maximum duration: up to 3.4 years) |
| Event Rate Per 100 Participant-Years For First Occurrence of Any Arterial Revascularizations | Event rate per 100 participant-years for first occurrence of any arterial revascularizations (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of first adjudicated and confirmed occurrence of any arterial revascularizations (maximum duration: up to 3.4 years) |
| Event Rate Per 100 Participant-Years For All-Cause Death | Event rate per 100 participant-years for all-cause death (adjudicated by adjudication committee) was reported. All-cause death was defined as the death due to any cause during the course of study. Event rate was calculated as the number of events per 100 participant-years at risk. | From baseline until the date of adjudicated and confirmed occurrence of all-cause death (maximum duration: up to 3.4 years) |
| Percent Change From Baseline in Low Density Lipoprotein Cholesterol at Week 14 | Baseline, Week 14 |
| Nominal Change From Baseline in Low Density Lipoprotein Cholesterol at Week 14 | Baseline, Week 14 |
| Percent Change From Baseline in Low Density Lipoprotein Cholesterol at Last Post-Baseline Measurement | Baseline, last post-baseline measurement (any time up to Week 140) |
| Percent Change From Baseline in Lipid Levels at Week 14 | Lipids included non-high density lipoprotein cholesterol (non-HDL-C), total cholesterol, very low density lipoprotein cholesterol (VLDL-C), remnant lipoprotein cholesterol (RLP-C), apolipoprotein B (Apo B), HDL-C and apolipoprotein A-I (Apo A-I). | Baseline, Week 14 |
| Percent Change From Baseline in Log-Transformed Lipoprotein (a) (Lp[a]) and Triglycerides at Week 14 | Baseline, Week 14 |
| Percent Change From Baseline in Log-Transformed High Sensitivity C-Reactive Protein (Hs-CRP) at Week 14 | Baseline, Week 14 |
| Athens |
| Alabama |
| 35611 |
| United States |
| Central Alabama Research | Birmingham | Alabama | 35209 | United States |
| Clinical Research Advantage, Inc./Simon Williamson Clinic | Birmingham | Alabama | 35211 | United States |
| Birmingham Heart Clinic, P.C. | Birmingham | Alabama | 35235 | United States |
| Cardiovascular Associates of the Southeast, LLC | Birmingham | Alabama | 35243 | United States |
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | United States |
| Appalachian Cardiovascular Associates | Fort Payne | Alabama | 35967 | United States |
| Fundamental Research, LLC | Gulf Shores | Alabama | 36542 | United States |
| Avant Research Associates, LLC | Guntersville | Alabama | 35976 | United States |
| Boyett Health Services | Hamilton | Alabama | 35570 | United States |
| Saadat Ansari Internal Medicine | Huntsville | Alabama | 35801 | United States |
| CB Flock Research Corporation | Mobile | Alabama | 36608 | United States |
| Alaska Heart Institute | Anchorage | Alaska | 99508 | United States |
| Phoenix Heart, PLLC | Glendale | Arizona | 85306 | United States |
| Arrowhead Internal Medicine | Glendale | Arizona | 85308 | United States |
| Clinical Research Advantage, Inc./Family Practice Specialists, Ltd. | Phoenix | Arizona | 85018 | United States |
| Redpoint Research | Phoenix | Arizona | 85029 | United States |
| Cochise Clinical Research | Sierra Vista | Arizona | 85635 | United States |
| Clinical Research Advantage, Inc. (Administrative Mailing Only) | Tempe | Arizona | 85282 | United States |
| Southwest Heart Group | Tucson | Arizona | 85710 | United States |
| University of Arizona Medical Center South Campus | Tucson | Arizona | 85713 | United States |
| Arizona Endocrine and Rheumatology Associates | Tucson | Arizona | 85715 | United States |
| Arkansas Heart Hospital Clinic | Little Rock | Arkansas | 72211 | United States |
| Arkansas Site Management Services, LLC | Little Rock | Arkansas | 72211 | United States |
| Cardiology Consultants of Orange County Medical Group Inc. | Anaheim | California | 92801 | United States |
| Premier Valley Medical Group | Bakersfield | California | 93309 | United States |
| Cardiovascular Research Foundation of Southern California | Beverly Hills | California | 90210 | United States |
| Westside Medical Associates of Los Angeles | Beverly Hills | California | 90211 | United States |
| Southbay Pharma Research | Buena Park | California | 90620 | United States |
| Med Center | Carmichael | California | 95608 | United States |
| Pioneer Medical Group | Cerritos | California | 90703 | United States |
| John Muir Physician Network Clinical Research Center | Concord | California | 94520 | United States |
| Atlantic Ave Medical Clinic Inc. | Cudahy | California | 90201 | United States |
| Multani Medical Group | Downey | California | 90241 | United States |
| Triwest Research Associates, LLC | El Cajon | California | 92020 | United States |
| Diagnamics, Inc. | Encinitas | California | 92024 | United States |
| T. Joseph Raoof, Md, Inc/Encino Research Center | Encino | California | 91436 | United States |
| Aviva Research | Escondido | California | 92025 | United States |
| Med Investigations, Inc. | Fair Oaks | California | 95628 | United States |
| Valley Research | Fresno | California | 93720 | United States |
| St. Jude Hospital Yorba Linda DBA St. Joseph Heritage Healthcare | Fullerton | California | 92835 | United States |
| Omnibus Clinical Research | La Palma | California | 90623 | United States |
| Alliance Research Centers | Laguna Hills | California | 92653 | United States |
| Prime Care Clinical Research Center | Laguna Hills | California | 92653 | United States |
| Clinical Trials Research | Lincoln | California | 95648 | United States |
| Long Beach Memorial Medical Center | Long Beach | California | 90806 | United States |
| American Institute of Research | Los Angeles | California | 90017 | United States |
| Intermed Group | Los Angeles | California | 90017 | United States |
| Academic Medical Research Institute | Los Angeles | California | 90022 | United States |
| Eastside Clinical Research Associates | Los Angeles | California | 90022 | United States |
| Richard S. Cherlin, MD | Los Gatos | California | 95032 | United States |
| Facey Medical Foundation | Mission Hills | California | 91345 | United States |
| California Medical Research Associates Inc. | Northridge | California | 91324 | United States |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | United States |
| Diabetes Associates Medical Group | Orange | California | 92868 | United States |
| Saviers Medical Group | Port Hueneme | California | 93041 | United States |
| Arch Health Partners | Poway | California | 92064 | United States |
| A. R. I. Clinical Trials, Inc. | Redondo Beach | California | 90277 | United States |
| California Research Foundation | San Diego | California | 92103-6204 | United States |
| San Diego Family Care dba Linda Vista Health Center | San Diego | California | 92111 | United States |
| San Diego Family Care | San Diego | California | 92111 | United States |
| Ritchken & First Md's | San Diego | California | 92117 | United States |
| Wetlin Research Associates, Inc. | San Diego | California | 92120 | United States |
| West Coast Research LLC | San Ramon | California | 94582 | United States |
| Syrentis Clinical Research | Santa Ana | California | 92705 | United States |
| Coastal Biomedical Research, Inc. | Santa Monica | California | 90404 | United States |
| Encompass Clinical Research | Spring Valley | California | 91978 | United States |
| St. Joseph's Medical Associates | Stockton | California | 95204 | United States |
| Westlake Medical Research | Thousand Oaks | California | 91360 | United States |
| Los Angeles Biomedical Research Institute at Harbor - UCLA Medical Center | Torrance | California | 90502 | United States |
| Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center | Torrance | California | 90502 | United States |
| Harbor - UCLA Medical Center | Torrance | California | 90509 | United States |
| Orange County Research Center | Tustin | California | 92780 | United States |
| Bayview Research Group | Valley Village | California | 91607 | United States |
| Coastal Metabolic Research Centre | Ventura | California | 93003 | United States |
| Ventura Clinical Trials | Ventura | California | 93003 | United States |
| Clinical Research Advantage, Inc. / Cassidy Medical Group - Vista | Vista | California | 92083 | United States |
| Allianz Research Institute | Westminster | California | 92683 | United States |
| American Institute of Research Studies | Whittier | California | 90603 | United States |
| Elite Clinical Trials, Inc. | Wildomar | California | 92595 | United States |
| Elite Clinical Trials, Incorporated | Wildomar | California | 92595 | United States |
| Colorado Springs Health Partners | Colorado Springs | Colorado | 80906 | United States |
| ExpressCare Clinical Research | Colorado Springs | Colorado | 80909 | United States |
| Lynn Institute of the Rockies | Colorado Springs | Colorado | 80909 | United States |
| Memorial Hospital: University of Colorado Health | Colorado Springs | Colorado | 80909 | United States |
| Lynn Institute of Denver | Denver | Colorado | 80246 | United States |
| Western Colorado Research, LLC | Glenwood Springs | Colorado | 81601 | United States |
| South Denver Cardiology Associates, PC | Littleton | Colorado | 80120 | United States |
| Connecticut Clinical Research, LLC | Bridgeport | Connecticut | 06606 | United States |
| Bridgeport Hospital | Bridgeport | Connecticut | 06610 | United States |
| Hartford Hospital | Hartford | Connecticut | 06102 | United States |
| Cardiology Associates of Fairfield County, PC | Stamford | Connecticut | 06905 | United States |
| Stamford Therapeutics Consortium | Stamford | Connecticut | 06905 | United States |
| Christiana Care Health Services, Inc. | Newark | Delaware | 19713 | United States |
| Alfieri Cardiology | Wilmington | Delaware | 19803 | United States |
| Capital Medical Associates, PC | Washington D.C. | District of Columbia | 20036 | United States |
| ACRC - Cardiology | Atlantis | Florida | 33462 | United States |
| Meridien Research | Brooksville | Florida | 34601 | United States |
| Gulf Coast Endocrine and Diabetes Center | Clearwater | Florida | 33756 | United States |
| Team Medical Research | Coral Gables | Florida | 33134 | United States |
| The Heart Group, PA | Daytona Beach | Florida | 32114 | United States |
| Cardiology Associates Research Company | Daytona Beach | Florida | 32117 | United States |
| Seidman Clinical Trials | Delray Beach | Florida | 33484 | United States |
| The Cardiology Center | Delray Beach | Florida | 33484 | United States |
| Continental Research Corp | Doral | Florida | 33126 | United States |
| Care Research Center Inc | Doral | Florida | 33166 | United States |
| Integrity Clinical Research, LLC | Doral | Florida | 33166 | United States |
| Moonshine Research Center, Inc. | Doral | Florida | 33166 | United States |
| Advanced Clinical Research of Miami (ACROM) International | Doral | Florida | 33172 | United States |
| Invesclinic, LLC | Fort Lauderdale | Florida | 33308 | United States |
| The Office of Alan Graff, MD, PA | Fort Lauderdale | Florida | 33308 | United States |
| The Center for Diabetes and Endocrine Care | Fort Lauderdale | Florida | 33312 | United States |
| Broward Health Medical Center (BHMC) (Broward General Medical Center (BGMC)) | Fort Lauderdale | Florida | 33316 | United States |
| The Office of Maxine E. Hamilton, MD, PA | Fort Lauderdale | Florida | 33316 | United States |
| State Of The Art Research, LLC | Hialeah | Florida | 33010 | United States |
| Direct Helpers Medical Center Inc | Hialeah | Florida | 33012 | United States |
| Research Physicians Network Alliance | Hollywood | Florida | 33021 | United States |
| Pines Clinical Research, Inc. | Hollywood | Florida | 33024 | United States |
| East Coast Institute for Research, LLC | Jacksonville | Florida | 32204 | United States |
| Westside Center for Clinical Research | Jacksonville | Florida | 32205 | United States |
| River City Clinical Research | Jacksonville | Florida | 32207 | United States |
| East Coast Institute for Research, LLC | Jacksonville | Florida | 32216 | United States |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | United States |
| Baker-Gilmore Cardiovascular Institute | Jacksonville | Florida | 32223 | United States |
| Solutions Through Advanced Research, Inc. | Jacksonville | Florida | 32256 | United States |
| Meridien Research | Lakeland | Florida | 33805 | United States |
| The Heart Institute at Largo | Largo | Florida | 33770 | United States |
| South Florida Clinical Research Institute | Margate | Florida | 33063 | United States |
| Accelovance | Melbourne | Florida | 32934 | United States |
| Future Clinical Research, Inc. | Miami | Florida | 33122 | United States |
| Advanced Clinical Research of Miami (ACROM) International | Miami | Florida | 33125 | United States |
| Project4Research, Inc | Miami | Florida | 33125 | United States |
| A & L Clinical Research | Miami | Florida | 33126 | United States |
| Finlay Medical Research | Miami | Florida | 33126 | United States |
| Pharmax Research Clinic, Inc. | Miami | Florida | 33126 | United States |
| South Florida Research Center, Inc. | Miami | Florida | 33135 | United States |
| Florida Medical Center & Research, Inc. | Miami | Florida | 33142 | United States |
| Medical Research Center | Miami | Florida | 33144 | United States |
| Nuren Medical & Research Center | Miami | Florida | 33144 | United States |
| Doctors Research Institute | Miami | Florida | 33145 | United States |
| Advanced Pharma CR, LLC | Miami | Florida | 33147 | United States |
| Coast Research Institute | Miami | Florida | 33155 | United States |
| My Community Research Center, Inc. | Miami | Florida | 33155 | United States |
| Columbus Clinical Services LLC | Miami | Florida | 33165 | United States |
| Cardiovascular Research Center of South Florida | Miami | Florida | 33173 | United States |
| Research Institute of South Florida, Inc. | Miami | Florida | 33173 | United States |
| A & O Research Center, Inc. | Miami | Florida | 33174 | United States |
| BWell Research Center | Miami | Florida | 33175 | United States |
| Pharmacology International Research, Inc. | Miami | Florida | 33175 | United States |
| Advanced Clinical Research | Miami | Florida | 33176 | United States |
| South Florida Research Group, LLC | Miami | Florida | 33176 | United States |
| International Research Associates, LLC | Miami | Florida | 33183 | United States |
| Kendall South Medical Center, Inc. | Miami | Florida | 33185 | United States |
| M & M Medical Center, Inc | Miami | Florida | 33185 | United States |
| Med Research Of Florida, LLC | Miami | Florida | 33186 | United States |
| Research Physicians Network Alliance | Miami Beach | Florida | 33140 | United States |
| G & I Medical Research LLC | Miami Lakes | Florida | 33014 | United States |
| Southwest Florida Research | Naples | Florida | 34102 | United States |
| BayCare Medical Group | New Port Richey | Florida | 34653 | United States |
| The Heart & Vascular Institute of Florida | New Port Richey | Florida | 34653 | United States |
| Bravo Health Care Center | North Bay Village | Florida | 33141 | United States |
| Harmony Clincal Research, Inc. | North Miami Beach | Florida | 33162 | United States |
| Florida Hospital Cardiovascular Institute | Orlando | Florida | 32803 | United States |
| Omega Research Consultants, LLC | Orlando | Florida | 32806 | United States |
| Aba Family Medicine, LLC | Ormond Beach | Florida | 32174 | United States |
| Millennium Research | Ormond Beach | Florida | 32174 | United States |
| Ribo Research, LLC dba Peninsula Research | Ormond Beach | Florida | 32174 | United States |
| A&R Research Group, LLC | Pembroke Pines | Florida | 33024 | United States |
| Research Physicians Network Alliance | Pembroke Pines | Florida | 33025 | United States |
| South Broward Research | Pembroke Pines | Florida | 33027 | United States |
| DBC Research USA | Pembroke Pines | Florida | 33029 | United States |
| DBC Research | Pembroke Pines | Florida | 33029 | United States |
| Cardiology Consultants | Pensacola | Florida | 32501 | United States |
| DMI Research, Inc. | Pinellas Park | Florida | 33782 | United States |
| Clincal Research of Florida | Plant City | Florida | 33563 | United States |
| Clinical Research of Central Florida | Plant City | Florida | 33563 | United States |
| Dr. Jeffrey Greiff MD, Office Of | Plantation | Florida | 33313-6066 | United States |
| Nova Clinical Research Collaborative | Plantation | Florida | 33313 | United States |
| St. Johns Center for Clinical Research | Ponte Vedra | Florida | 32081 | United States |
| Charlotte Heart Group Research Center | Port Charlotte | Florida | 33952 | United States |
| Intercoastal Medical Group | Sarasota | Florida | 34232 | United States |
| Cardiovascular Center Of Sarasota | Sarasota | Florida | 34239 | United States |
| Heart & Vascular Center Research | Sarasota | Florida | 34239 | United States |
| Intercoastal Medical Group (Drug Shipment Address and Administrative) | Sarasota | Florida | 34239 | United States |
| The Office of Bridget Bellingar, DO | Seminole | Florida | 33777 | United States |
| Meridien Research | St. Petersburg | Florida | 33709 | United States |
| Advance Medical Research | St. Petersburg | Florida | 33713 | United States |
| Vita Health & Medical Center, Inc./Concept Clinical Trials, LLC | Tamarac | Florida | 33319 | United States |
| Interventional Cardiac Consultants | Trinity | Florida | 34655 | United States |
| Cardiology Partners Clinical Research Institute | Wellington | Florida | 33449 | United States |
| Cleveland Clinic Cardiology Associates | West Palm Beach | Florida | 33401 | United States |
| Metabolic Research Institute, Inc. | West Palm Beach | Florida | 33401 | United States |
| Clinical Research of Central Florida | Winter Haven | Florida | 33880 | United States |
| Atlanta Diabetes Associates | Atlanta | Georgia | 30318 | United States |
| Emory University Hospital | Atlanta | Georgia | 30322 | United States |
| Atlanta Center For Medical Research | Atlanta | Georgia | 30331 | United States |
| Columbus Regional Research Institute | Columbus | Georgia | 31904 | United States |
| Rockdale Medical Research Associates | Conyers | Georgia | 30094 | United States |
| Georgia Heart Specialists, LLC | Covington | Georgia | 30014 | United States |
| Neurostudies.Net, LLC | Decatur | Georgia | 30033 | United States |
| Alta Pharmaceutical Research Center | Dunwoody | Georgia | 30338 | United States |
| In-Quest Medical Research, LLC | Norcross | Georgia | 30071 | United States |
| Atlanta Center for Clinical Research / Internal Medicine | Roswell | Georgia | 30075 | United States |
| Dr. B. Abraham, P.C. | Snellville | Georgia | 30039 | United States |
| Georgia Clinical Research, LLC | Snellville | Georgia | 30078 | United States |
| Clinical Research Atlanta | Stockbridge | Georgia | 30281 | United States |
| East-West Medical Research Institute | Honolulu | Hawaii | 96814 | United States |
| Elite Clinial Trials, LLLP | Blackfoot | Idaho | 83221 | United States |
| Elite Clinial Trials | Blackfoot | Idaho | 83221 | United States |
| St. Luke's Idaho Cardiology Associates | Caldwell | Idaho | 83605 | United States |
| Solaris Clinical Research | Meridian | Idaho | 83646 | United States |
| Saltzer Medical Group, PA | Nampa | Idaho | 83686-6011 | United States |
| Northwest Heart Clinical Research, LLC | Arlington Heights | Illinois | 60005 | United States |
| Clinical Research Advantage, Inc./Michigan Avenue Internists | Chicago | Illinois | 60604 | United States |
| Apex Medical Research, AMR, Inc. | Chicago | Illinois | 60616 | United States |
| Clinical Research Advantage, Inc./Medical and Procedural Specialists of Illinois | Chicago | Illinois | 60631 | United States |
| Evanston Premier Healthcare Research, LLC | Evanston | Illinois | 60201 | United States |
| Clinical Investigation Specialists, Inc | Gurnee | Illinois | 60031 | United States |
| Heart Care Centers of Illinois | Mokena | Illinois | 60448 | United States |
| Advanced CardioVascular Consultants | Rock Island | Illinois | 61201 | United States |
| Investigators Research Group, LLC | Brownsburg | Indiana | 46112 | United States |
| Investigative Clinical Research of Indiana, LLC | Elwood | Indiana | 46036 | United States |
| Deaconess Clinic Downtown | Evansville | Indiana | 47713 | United States |
| Clinical Research Advantage, Inc. (IP Shipment and Research Site) | Evansville | Indiana | 47714 | United States |
| MediSphere Medical Research Center, LLC | Evansville | Indiana | 47714 | United States |
| Clinical Research Advantage, Inc. / Family Medicine Associates | Evansville | Indiana | 47725 | United States |
| Deaconess Clinic Mt. Pleasant | Evansville | Indiana | 47725 | United States |
| American Health Network of Indiana LLC | Franklin | Indiana | 46131 | United States |
| American Health Network of Indiana, LLC | Greenfield | Indiana | 46140 | United States |
| American Health Network of Indiana, LLC | Muncie | Indiana | 47304 | United States |
| Cardiovascular Research of Northwest Indiana, LLC | Munster | Indiana | 46321 | United States |
| Buynak Clinical Research, P.C. | Valparaiso | Indiana | 46383 | United States |
| West Broadway Clinic | Council Bluffs | Iowa | 51501 | United States |
| Clinical Research Advantage, Inc. | Council Bluffs | Iowa | 51503 | United States |
| Midwest Cardiovascular Research Foundation | Davenport | Iowa | 52803 | United States |
| University of Iowa College of Public Health - Preventive Intervention Center | Iowa City | Iowa | 52242 | United States |
| Northeast Iowa Medical Education Foundation | Waterloo | Iowa | 50702 | United States |
| The Iowa Clinic, PC | West Des Moines | Iowa | 50266 | United States |
| Hutchinson Clinic, P.A | Hutchinson | Kansas | 67502 | United States |
| University Of Kansas Medical Center | Kansas City | Kansas | 66160 | United States |
| Heartland Research Associates, LLC | Newton | Kansas | 67114 | United States |
| Midwest Heart & Vascular Specialists, LLC | Overland Park | Kansas | 66209 | United States |
| Women's & Family Care, LLC D.B.A GTC Research | Shawnee Mission | Kansas | 66218 | United States |
| Central Cardiology Associates Research | Elizabethtown | Kentucky | 42701 | United States |
| The Research Group of Lexington, LLC | Lexington | Kentucky | 40503 | United States |
| L-MARC Research Center | Louisville | Kentucky | 40213 | United States |
| Research Integrity, LLC. | Owensboro | Kentucky | 42303 | United States |
| Alexandria Cardiology Clinic | Alexandria | Louisiana | 71301 | United States |
| Avant Research Associates, LLC | Crowley | Louisiana | 70526 | United States |
| Centex Studies | Lake Charles | Louisiana | 70601 | United States |
| Imperial Health, LLC | Lake Charles | Louisiana | 70601 | United States |
| American Clinical Research, LLC | Marrero | Louisiana | 70072 | United States |
| West Jefferson Heart Clinic of Louisiana New Orleans Physician Services, Inc. | Marrero | Louisiana | 70072 | United States |
| Clinical Trials of America LA | Monroe | Louisiana | 71201 | United States |
| KAMP Medical Research Inc. | Natchitoches | Louisiana | 71457 | United States |
| Grace Research, LLC | Shreveport | Louisiana | 71105 | United States |
| Maine Research Associates | Auburn | Maine | 04210 | United States |
| Acadia Clinical Research, LLC | Bangor | Maine | 04401 | United States |
| Cranbrook Cardiology Research Associates | Westbrook | Maine | 04092 | United States |
| Anne Arundel Medical Center | Annapolis | Maryland | 21401 | United States |
| MedStar Cardiology Associates | Annapolis | Maryland | 21401 | United States |
| MedStar Chesapeake CardioVascular Associates | Baltimore | Maryland | 21204 | United States |
| MedStar Union Memorial Heart Specialists | Baltimore | Maryland | 21218 | United States |
| Maryland Cardiovascular Specialists | Baltimore | Maryland | 21229 | United States |
| Overlea Personal Physicians | Baltimore | Maryland | 21236 | United States |
| Shahid Saeed, MD, PC | Baltimore | Maryland | 21237 | United States |
| Maryland Heart Associates, LLC | Glen Burnie | Maryland | 21061 | United States |
| Lutherville Personal Physicians | Lutherville | Maryland | 21093 | United States |
| MD Medical Research | Oxon Hill | Maryland | 20745 | United States |
| Metro West Medical Center Research Clinic | Framingham | Massachusetts | 01702 | United States |
| Metro West Medical Center | Framingham | Massachusetts | 01702 | United States |
| MetroWest Medical Center - Pharmacy Department | Framingham | Massachusetts | 01702 | United States |
| Pentucket Medical Associates, LLC | Haverhill | Massachusetts | 01830 | United States |
| ActivMed Practices and Research, Inc. | Methuen | Massachusetts | 01844 | United States |
| Charles River Medical Associates | Natick | Massachusetts | 01760 | United States |
| Endeavor Medical Research | Alpena | Michigan | 49707 | United States |
| St. Joseph Mercy Health System | Ann Arbor | Michigan | 48106 | United States |
| University of Michigan - Domino Farms | Ann Arbor | Michigan | 48106 | United States |
| IHA Chelsea Family & Internal Medicine | Chelsea | Michigan | 48118 | United States |
| Healthy Heart Cardiology | Grandville | Michigan | 49418 | United States |
| Westside Family Medical Center, Pc | Kalamazoo | Michigan | 49009 | United States |
| Sparrow Clinical Research Institute | Lansing | Michigan | 48912 | United States |
| Sparrow Thoracic & Cardiovascular Institute | Lansing | Michigan | 48912 | United States |
| Detroit Clinical Research Center, PC | Livonia | Michigan | 48154 | United States |
| MidMichigan Medical Center Midland | Midland | Michigan | 48670 | United States |
| Michigan Cardio Vascular Institute | Saginaw | Michigan | 48601 | United States |
| Tri-County Research, Inc. | Sterling Heights | Michigan | 48310 | United States |
| Medical Research Associates, Inc. | Traverse City | Michigan | 49684 | United States |
| Oakland Medical Research Center | Troy | Michigan | 48085 | United States |
| Arcturus Healthcare, PLC, Troy Internal Medicine Research Division | Troy | Michigan | 48098 | United States |
| Michigan Heart & Vascular Institute | Ypsilanti | Michigan | 48197 | United States |
| Duluth Clinic, dba Essentia Health Duluth Clinic Investigational Drug Room | Duluth | Minnesota | 55805 | United States |
| St. Mary's Medical Center (Primary Practice Site) | Duluth | Minnesota | 55805 | United States |
| Radiant Research, Inc. | Edina | Minnesota | 55435 | United States |
| Minneapolis Clinic of Neurology | Golden Valley | Minnesota | 55422 | United States |
| Allina Health System, dba Abbott Northwestern Hospital | Minneapolis | Minnesota | 55407 | United States |
| Lillehei Clinical Research Unit, University of Minnesota | Minneapolis | Minnesota | 55455 | United States |
| CentraCare Heart and Vascular Center | Saint Cloud | Minnesota | 56303 | United States |
| HealthEast Medical Research Institute | Saint Paul | Minnesota | 55102 | United States |
| HealthEast St. Joseph's Hospital Pharmacy | Saint Paul | Minnesota | 55102 | United States |
| Phillips Medical Services, PLLC | Jackson | Mississippi | 39209 | United States |
| Olive Branch Family Medical Center | Olive Branch | Mississippi | 38654 | United States |
| Cardiology Associates Research, LLC | Tupelo | Mississippi | 38801 | United States |
| Missouri Cardiovascular Specialists, LLP | Columbia | Missouri | 65201 | United States |
| Saint Luke's Lipid and Diabetes Research Center | Kansas City | Missouri | 64111 | United States |
| Kansas City VA Medical Center | Kansas City | Missouri | 64128-2226 | United States |
| Mercy Research | St Louis | Missouri | 63141 | United States |
| Glacier View Research Institute | Kalispell | Montana | 55901 | United States |
| Glacier View Research Institute, Cardiology | Kalispell | Montana | 59901 | United States |
| Montana Medical Research Inc. | Missoula | Montana | 59808 | United States |
| Clinical Research Advantage, Inc./Skyline Medical Center, PC | Elkhorn | Nebraska | 68022 | United States |
| Bryan Heart | Lincoln | Nebraska | 68506 | United States |
| Creighton Diabetes Center | Omaha | Nebraska | 68131 | United States |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198-4120 | United States |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198-4130 | United States |
| AB Clinical Trials | Las Vegas | Nevada | 89119 | United States |
| Clinical Research Of South Nevada | Las Vegas | Nevada | 89121 | United States |
| Clinical Research Advantage, Inc. | Las Vegas | Nevada | 89128 | United States |
| John V. Bernard, MD dba Wellness and Research Center | Belvidere | New Jersey | 07823 | United States |
| Advanced Heart Care LLC | Bridgewater | New Jersey | 08807 | United States |
| Lourdes Cardiology Services | Cherry Hill | New Jersey | 08034 | United States |
| USMA Clinical Research | Elizabeth | New Jersey | 07201 | United States |
| Lourdes Cardiology Services | Hammonton | New Jersey | 08037 | United States |
| NJ Heart | Linden | New Jersey | 07036 | United States |
| Arysmed LLC | Lodi | New Jersey | 07644 | United States |
| Amici Clinical Research, LLC | Martinsville | New Jersey | 08836 | United States |
| Rutgers Biomedical and Health Sciences-Robert Wood Johnson Medical School | New Brunswick | New Jersey | 08901 | United States |
| Cardiac and Endovascular Associates | Ridgewood | New Jersey | 07450 | United States |
| The Valley Hospital | Ridgewood | New Jersey | 07450 | United States |
| Cardio Metabolic Institute | Somerset | New Jersey | 08873 | United States |
| TLB Research LLC | Trenton | New Jersey | 08611 | United States |
| Lourdes Cardiology Services | Voorhees Township | New Jersey | 08043 | United States |
| Westwood Cardiology Associates | Westwood | New Jersey | 07675 | United States |
| Albuquerque Clinical Trials, Inc. | Albuquerque | New Mexico | 87102 | United States |
| Albany Medical College, Division of Community Endocrinology | Albany | New York | 12206 | United States |
| Sorin Medical, P.C. | Brooklyn | New York | 11214 | United States |
| NY Total Medical Care, PC | Brooklyn | New York | 11215 | United States |
| NY Scientific | Brooklyn | New York | 11235 | United States |
| Buffalo Heart Group, Llp | Buffalo | New York | 14215 | United States |
| NYU Hudson Valley Cardiology | Cortlandt Manor | New York | 10567 | United States |
| Scott Research,Inc | Laurelton | New York | 11413 | United States |
| SJH Cardiology Associates | Liverpool | New York | 13088 | United States |
| Long Island Heart Associates | Mineola | New York | 11501 | United States |
| Mid Hudson Medical Research, PLLC | New Windsor | New York | 12553 | United States |
| Manhattan Medical Research Practice | New York | New York | 10016 | United States |
| Peters Medical Research NY, LLC | New York | New York | 10016 | United States |
| Weill Cornell Medical College | New York | New York | 10021 | United States |
| DiGiovanna Institute for Medical Education And Research | North Massapequa | New York | 11758-1802 | United States |
| Hudson Valley Cardiovascular Practice, PC | Poughkeepsie | New York | 12601 | United States |
| Rochester Clinical Research, Inc. | Rochester | New York | 14609 | United States |
| Institute for Clinical Studies | Rosedale | New York | 11422 | United States |
| Saratoga Clinical Research, LLC | Saratoga Springs | New York | 12866 | United States |
| Central New York Cardiology | Utica | New York | 13501 | United States |
| Great Lakes Medical Research | Westfield | New York | 14787 | United States |
| Buffalo Medical Group - Research Department | Williamsville | New York | 14221 | United States |
| Buffalo Medical Group | Williamsville | New York | 14221 | United States |
| Kernodle Clinic, Department of the Private Diagnostic Clinic, PLLC | Burlington | North Carolina | 27215 | United States |
| Novant Health Clinical Research | Charlotte | North Carolina | 28204 | United States |
| Novant Health Heart and Vascular Institute | Charlotte | North Carolina | 28204 | United States |
| PMG Research of Charlotte | Charlotte | North Carolina | 28209 | United States |
| Sensenbrenner Primary Care | Charlotte | North Carolina | 28277 | United States |
| NC Heart and Vascular | Clayton | North Carolina | 27520 | United States |
| LeBauer Cardiovascular Research Foundation | Greensboro | North Carolina | 27401 | United States |
| Clinical Trials of America, Inc. | Hickory | North Carolina | 28601 | United States |
| Carolina Cardiology Cornerstone | High Point | North Carolina | 27262 | United States |
| Clinical Trials of America- NC, LLC | Lenoir | North Carolina | 28645 | United States |
| Research Institute of the Carolinas of PiedmontHealthcare, PA | Mooresville | North Carolina | 28117 | United States |
| Burke Primary Care | Morganton | North Carolina | 28655 | United States |
| Eastern Nephrology Associates | New Bern | North Carolina | 28562 | United States |
| Boice Willis Clinic | Rocky Mount | North Carolina | 27804 | United States |
| PMG Research of Rock Mount, LLC - Patient Intake | Rocky Mount | North Carolina | 27804 | United States |
| Piedmont Healthcare/Research | Statesville | North Carolina | 28625 | United States |
| PMG Research of Wilmington, LLC | Wilmington | North Carolina | 28401 | United States |
| Wake Forest University School of Medicine | Winston-Salem | North Carolina | 27157 | United States |
| Lillestol Research LLC | Fargo | North Dakota | 58103 | United States |
| Radiant Research, Inc. | Akron | Ohio | 44311 | United States |
| The Lindner Center for Research and Education at The Christ Hospital | Cincinnati | Ohio | 45219 | United States |
| Metabolic and Atherosclerosis Research Center | Cincinnati | Ohio | 45227 | United States |
| Sterling Research Group, Ltd. | Cincinnati | Ohio | 45246 | United States |
| Rapid Medical Research, Inc. | Cleveland | Ohio | 44122 | United States |
| Cleveland Clinic - Taussig Cancer Institute | Cleveland | Ohio | 44195 | United States |
| Radiant Research, Inc. | Columbus | Ohio | 43212 | United States |
| Optimed Research, LTD | Columbus | Ohio | 43235 | United States |
| Premier Health Specialists, Inc (dba Dayton Heart Center) | Dayton | Ohio | 45414 | United States |
| PriMed Clinical Research | Dayton | Ohio | 45419 | United States |
| North Ohio Heart Center (Administrative Only) | Elyria | Ohio | 44035 | United States |
| North Ohio Heart Center | Elyria | Ohio | 44035 | United States |
| North Ohio Heart Center | Lorain | Ohio | 44053 | United States |
| SV Research, LLC | Marion | Ohio | 43302 | United States |
| Daniel G. Williams, MD | Perrysburg | Ohio | 43551 | United States |
| North Ohio Heart Center, Inc. | Sandusky | Ohio | 44870 | United States |
| North Ohio Heart Center | Sandusky | Ohio | 44870 | United States |
| ProMedica Northwest Ohio Cardiology Consultants | Toledo | Ohio | 43615 | United States |
| Mercy Health Youngstown, LLC d/b/a St. Elizabeth Youngstown Hospital | Youngstown | Ohio | 44501 | United States |
| LION Research | Norman | Oklahoma | 73072 | United States |
| COR Clinical Research LLC | Oklahoma City | Oklahoma | 73103 | United States |
| Oklahoma Heart Hospital Physicians | Oklahoma City | Oklahoma | 73120 | United States |
| Oklahoma Heart Hospital Research Foundation | Oklahoma City | Oklahoma | 73120 | United States |
| Oklahoma Heart Hospital | Oklahoma City | Oklahoma | 73120 | United States |
| South Oklahoma Heart Research, LLC | Oklahoma City | Oklahoma | 73135 | United States |
| Integrated Medical Research PC | Ashland | Oregon | 97520 | United States |
| Hillsboro Cardiology, P.C. | Hillsboro | Oregon | 97123 | United States |
| Portland Preventive Cardiology LLC | Portland | Oregon | 97225 | United States |
| Abington Memorial Hospital (administrative only) | Abington | Pennsylvania | 19001 | United States |
| Clinical Research Associates of Central PA | Altoona | Pennsylvania | 16602 | United States |
| Brandywine Clinical Research | Downingtown | Pennsylvania | 19335-2620 | United States |
| Doylestown Cardiology Associates - VIAA | Doylestown | Pennsylvania | 18901 | United States |
| Doylestown Health Cardiology, a division of Doylestown Health Physicians | Doylestown | Pennsylvania | 18901 | United States |
| AMH/Feasterville Family Health Care Center | Feasterville-Trevose | Pennsylvania | 19053 | United States |
| Greater Pittsburgh Vascular | Jefferson Hills | Pennsylvania | 15025 | United States |
| Detweiler Family Medicine & Associates, PC | Lansdale | Pennsylvania | 19446 | United States |
| Green and Seidner Family Practice Associates | Lansdale | Pennsylvania | 19446 | United States |
| Family Medical Associates | Levittown | Pennsylvania | 19056 | United States |
| Mercer Bucks Cardiology | Newtown | Pennsylvania | 18940 | United States |
| Philadelphia Health Associates-Adult Medicine | Philadelphia | Pennsylvania | 19146 | United States |
| Allegheny Endocrinology Associates | Pittsburgh | Pennsylvania | 15212 | United States |
| Preferred Primary Care Physicians | Pittsburgh | Pennsylvania | 15236 | United States |
| Guthrie Medical Group, PC | Sayre | Pennsylvania | 18840 | United States |
| SFM Clinical Trials, Inc. | Scotland | Pennsylvania | 17254 | United States |
| Fay-West Family Practice | Scottdale | Pennsylvania | 15683 | United States |
| Grand View - Lehigh Valley Health Services, Buxmont Cardiology Division | Sellersville | Pennsylvania | 18960 | United States |
| Montgomery Medical, Inc. | Smithfield | Pennsylvania | 15478 | United States |
| Preferred Primary Care Physicians | Uniontown | Pennsylvania | 15401 | United States |
| Berks Cardiologists, Ltd. | Wyomissing | Pennsylvania | 19610 | United States |
| Coastal Cardiolgy | Charleston | South Carolina | 29407 | United States |
| Upstate Pharmaceutical Research | Greenville | South Carolina | 29615 | United States |
| Mountain View Clinical Research, Inc. | Greer | South Carolina | 29651 | United States |
| Black Hills Cardiovascular-Regional Health Research | Rapid City | South Dakota | 57701 | United States |
| Mid-Cumberland Infectious Disease Consultants, PLC | Clarksville | Tennessee | 37043 | United States |
| Collierville Medical Specialists | Collierville | Tennessee | 38017 | United States |
| Stern Cardiovascular Foundation, Inc. | Germantown | Tennessee | 38138 | United States |
| Holston Medical Group | Kingsport | Tennessee | 37660 | United States |
| New Phase Research & Development | Knoxville | Tennessee | 37909 | United States |
| PMG Research,Inc d/b/a PMG Research of Knoxville | Knoxville | Tennessee | 37912 | United States |
| Cardiovascular Research of Knoxville | Knoxville | Tennessee | 37917 | United States |
| New Orleans Center for Clinical Research | Knoxville | Tennessee | 37920 | United States |
| Volunteer Research Group | Knoxville | Tennessee | 37920 | United States |
| Baptist Memorial Medical Group, Inc. | Memphis | Tennessee | 38119 | United States |
| The Green Clinic, PC | Memphis | Tennessee | 38119 | United States |
| Southwind Medical Specialists | Memphis | Tennessee | 38125 | United States |
| Tennessee Center for Clinical Trials | Tullahoma | Tennessee | 37388 | United States |
| Trinity Clinical Research, LLC | Tullahoma | Tennessee | 37388 | United States |
| PharmaTex Research | Amarillo | Texas | 79106 | United States |
| Arlington Family Research Center, Inc. | Arlington | Texas | 76012 | United States |
| Texas Diabetes & Endocrinology | Austin | Texas | 78731 | United States |
| Austin Heart, PLLC | Austin | Texas | 78756 | United States |
| Southeast Texas Cardiology Associates II, L.L.P. | Beaumont | Texas | 77702 | United States |
| Southeast Texas Clinical Research Center | Beaumont | Texas | 77702 | United States |
| Aztec Medical Research, LLC | Channelview | Texas | 77530 | United States |
| Corsicana Medical Research, PLLC | Corsicana | Texas | 75110 | United States |
| Baylor Research Institute IRB | Dallas | Texas | 75204 | United States |
| Protenium Clinical Research, LLC | Dallas | Texas | 75208 | United States |
| VA North Texas Health Care System - Dallas VAMC | Dallas | Texas | 75216 | United States |
| Baylor Heart and Vascular Institute | Dallas | Texas | 75226 | United States |
| Dallas Diabetes and Endocrine Center | Dallas | Texas | 75230 | United States |
| Cardiovascular Research Institute of Dallas | Dallas | Texas | 75231 | United States |
| Radiant Research, Inc. | Dallas | Texas | 75231 | United States |
| Research Institute of Dallas | Dallas | Texas | 75231 | United States |
| Parkland Health and Hospital System | Dallas | Texas | 75235 | United States |
| Baylor University Medical Center / Department of Pharmacy | Dallas | Texas | 75246 | United States |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390-8565 | United States |
| (For IP storage only)The University of Texas Southwestern Medical Center | Dallas | Texas | 75390-9034 | United States |
| The University of Texas Southwestern Medical Center | Dallas | Texas | 75390-9034 | United States |
| William P. Clements Jr. University Hospital | Dallas | Texas | 75390 | United States |
| Doctors Hospital At Renaissance | Edinburg | Texas | 78539 | United States |
| Amir Malik Research | Fort Worth | Texas | 76104 | United States |
| The Medical Group of Texas | Fort Worth | Texas | 76104 | United States |
| T & R Clinic, PA | Fort Worth | Texas | 76117 | United States |
| Rockwood Medical Clinic | Fort Worth | Texas | 76164 | United States |
| San Gabriel Clinical Research, LLC | Georgetown | Texas | 78626 | United States |
| East Texas Cardiology PA | Houston | Texas | 77002 | United States |
| Spring Clinical Research | Houston | Texas | 77002 | United States |
| Med Tech Research, LP | Houston | Texas | 77024 | United States |
| Prime Care Medical Group | Houston | Texas | 77024 | United States |
| Associates in Medicine, PA | Houston | Texas | 77027 | United States |
| Alan S. Hoffman, M.D. | Houston | Texas | 77030 | United States |
| Baylor College of Medicine | Houston | Texas | 77030 | United States |
| ICTR/Baylor College of Medicine | Houston | Texas | 77030 | United States |
| Investigational Drug Services | Houston | Texas | 77030 | United States |
| Memorial Hermann Hospital, Texas Medical Center- UT Health Clinical Research Unit | Houston | Texas | 77030 | United States |
| Memorial Hermann Hospital, Texas Medical Center | Houston | Texas | 77030 | United States |
| The University of Texas Health Science Center at Houston- UT Physicians | Houston | Texas | 77030 | United States |
| Centex Studies, Inc. | Houston | Texas | 77058 | United States |
| Northwest Houston Cardiology, P.A. | Houston | Texas | 77070 | United States |
| Texas Center for Drug Development, Inc | Houston | Texas | 77081 | United States |
| Private Practice Leadership, LLC | Houston | Texas | 77094 | United States |
| Protenium Clinical Research LLC | Hurst | Texas | 76054 | United States |
| South Texas Cardiovascular Consultants, PLLC | Kerrville | Texas | 78028 | United States |
| DCOL Center for Clinical Research | Longview | Texas | 75605 | United States |
| Caprock Cardiac Center Research Institute Inc. | Lubbock | Texas | 79410 | United States |
| Midland Clinical Research Center | Midland | Texas | 79707 | United States |
| Hill Country Medical Associates | New Braunfels | Texas | 78130 | United States |
| North Hills Medical Research, Inc. | North Richland Hills | Texas | 76180 | United States |
| Grace Research, LLC | Palestine | Texas | 75801 | United States |
| Med-Olam Clinical Research, LLC. | Pasadena | Texas | 77504 | United States |
| Austin Institute for Clinicla Research,Inc. | Pflugerville | Texas | 78660 | United States |
| Centex Studies, Inc | Pharr | Texas | 78577 | United States |
| South Texas Cardiovascular Consultants, PLLC | San Antonio | Texas | 78201 | United States |
| Sun Research Institute | San Antonio | Texas | 78215 | United States |
| Southwest Clinic | San Antonio | Texas | 78221 | United States |
| FIRST Outpatient Research Unit | San Antonio | Texas | 78229 | United States |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78229 | United States |
| University of Texas Health Science Center San Antonio | San Antonio | Texas | 78229 | United States |
| University of Texas Health Sciences Center at San Antonio | San Antonio | Texas | 78229 | United States |
| Victorium Clinical Research | San Antonio | Texas | 78231 | United States |
| Bandera Family Health Care, LLC | San Antonio | Texas | 78249 | United States |
| Northeast Clinical Research of San Antonio, LLC (NECRSA, LLC) | Schertz | Texas | 78154 | United States |
| Acacia Medical Research Institute, LLC/Royal Oaks Medcical Home and Wellness Clinics | Sugar Land | Texas | 77478 | United States |
| IP + Dry ice deliveries Sugar Lakes Family Practice | Sugar Land | Texas | 77478 | United States |
| Sugar Lakes Family Practice | Sugar Land | Texas | 77479 | United States |
| Northwest Houston Heart Center | Tomball | Texas | 77375-4536 | United States |
| Admin & Storage only:Northwest Heart Center | Tomball | Texas | 77375 | United States |
| Northwest Heart Center | Tomball | Texas | 77375 | United States |
| Northwest Houston Clinical Research, PLLC | Tomball | Texas | 77375 | United States |
| Victoria Heart & Vascular Center, PA | Victoria | Texas | 77901 | United States |
| Victoria Heart and Vascular Center, PA | Victoria | Texas | 77901 | United States |
| Utah Cardiology, PC | Bountiful | Utah | 84010 | United States |
| Utah Cardiology, P.C. | Layton | Utah | 84041 | United States |
| Paramount Medical Care | Ogden | Utah | 84405 | United States |
| Aspen Clinical Research LLC | Orem | Utah | 84058 | United States |
| Revere Health | Provo | Utah | 84604 | United States |
| Optimum Clinical Research, Inc | Salt Lake City | Utah | 84102 | United States |
| Wasatch Clinical Research, LLC | Salt Lake City | Utah | 84107 | United States |
| Holladay Family Practice | Salt Lake City | Utah | 84117 | United States |
| Heart Center at St. Mark's Hospital | Salt Lake City | Utah | 84124 | United States |
| Clinical Research Institute of Northern Virginia | Burke | Virginia | 22015-4202 | United States |
| Burke Internal Medicine & Research | Burke | Virginia | 22015 | United States |
| Virginia Heart | Falls Church | Virginia | 22042 | United States |
| Seven Corners Medical Research Center | Falls Church | Virginia | 22044 | United States |
| Heart Care Associates, P.C. | Hopewell | Virginia | 23860 | United States |
| Virginia Research Center | Midlothian | Virginia | 23114 | United States |
| Chippenham and Johnston Willis Hospitals, Inc. dba CJW Medical Center | Richmond | Virginia | 23225 | United States |
| Retreat Cardiology LLC, dba Cardiology Associates of Richmond | Richmond | Virginia | 23225 | United States |
| Roanoke Heart Institute | Roanoke | Virginia | 24014 | United States |
| Hampton Roads Center for Clinical Research | Suffolk | Virginia | 23435 | United States |
| The Office of Daniel W. Gottlieb, MD, PS | Burien | Washington | 98166 | United States |
| Premier Clinical Research | Spokane | Washington | 99202 | United States |
| Universal Research Group, LLC | Tacoma | Washington | 98405 | United States |
| Walla Walla Clinic | Walla Walla | Washington | 99362 | United States |
| Wenatchee Valley Hospital & Clinics | Wenatchee | Washington | 98801 | United States |
| Fairmont General Hospital | Fairmont | West Virginia | 26554 | United States |
| Prevea Clinic, Inc. | Green Bay | Wisconsin | 54303 | United States |
| Clinical Investigation Specialists, Inc. | Kenosha | Wisconsin | 53142 | United States |
| Waukesha Heart Foundation | Waukesha | Wisconsin | 53188 | United States |
| Instituto de Investigaciones Clinicas Bahia Blanca | Bahía Blanca | Buenos Aires | B8000FTD | Argentina |
| Hospital Italiano Regional del Sur | Bahía Blanca | Buenos Aires | B8001BXM | Argentina |
| Hospital Britanico De Buenos Aires | Ciudad Autonoma de B. Aires | Buenos Aires | C1280AEB | Argentina |
| CEDIC - Consultorios Medicos | Ciudad Autonoma de Buenos Aires | Buenos Aires | C1425DES | Argentina |
| Clinica Coronel Suarez S.A. | Coronel Suárez | Buenos Aires | B7540GHD | Argentina |
| Framingham Centro Medico | La Plata | Buenos Aires | B1902COS | Argentina |
| CIMeL CHAHIN CHAHIN S.A. | Lanús Este | Buenos Aires | B1824KAJ | Argentina |
| Instituto de Investigaciones Clinicas Mar del Plata | Mar del Plata | Buenos Aires | B7600FZN | Argentina |
| Instituto de Investigaciones Clinicas Quilmes | Quilmes | Buenos Aires | B1878GEG | Argentina |
| DIM Clinica Privada | Ramos Mejía | Buenos Aires | B1704ETD | Argentina |
| Instituto de Investigaciones Clinicas Zarate | Zárate | Buenos Aires | B2800DGH | Argentina |
| STAT Research S.A. | C.a.b.a | Buenos Aires F.D. | C1023AAB | Argentina |
| Consultorios Asociados de Endocrinologia e Investigacion Clinica Aplicada | C.a.b.a | C.a.b.a. | C1425AGC | Argentina |
| Clinica Privada de Especialidades Medicas | Villa María | Córdoba Province | 5901 | Argentina |
| CIPADI Centro Integral de Prevencion y Atencion en Diabetes | Godoy Cruz | Mendoza Province | M5501ARP | Argentina |
| Hospital Interzonal Gral. de Agudos Dr. Jose Penna | Bahía Blanca | PCIA de Buenos Aires | B8001DDU | Argentina |
| IMEP Instituto Medico Elsa Perez | Ciudadela | PCIA de Buenos Aires | 1702 | Argentina |
| Instituto Medico Aguero | Morón | PCIA de Buenos Aires | B1708CGU | Argentina |
| Corporacion Medica de San Martin | San Martin | PCIA de Buenos Aires | B1650CSQ | Argentina |
| Cordis - Instituto del Corazon | Resistencia | PCIA de Chaco | H3500CDM | Argentina |
| Hospital de Alta Complejidad "Pte. Juan Domingo Peron" | Formosa | PCIA de Formosa | 3600 | Argentina |
| Hospital Provincial Dr. Jose Maria Cullen | Santa Fe | PCIA de Santa FE | S3000EOZ | Argentina |
| Centro De Investigaciones Clinicas Del Litoral S.R.L. | Santa Fe | PCIA de Santa FE | S3000FWO | Argentina |
| Cedir S.A - Centro De Diagnostico Y Rehabilitacion S.A. | Santa Fe | PCIA de Santa FE | S3004CVS | Argentina |
| Centro Modelo de Cardiologia | San Miguel de Tucumán | PCIA de Tucuman | T4000IFL | Argentina |
| Instituto de Hematologia y Medicina Clinica "Dr. Ruben A. Davoli" | Rosario | Pcia. de Santa FE | S2000CFK | Argentina |
| Instituto de Investigaciones Clinicas Rosario | Rosario | Santa Fe Province | S2000CVD | Argentina |
| Instituto Medico CENICLAR - Central de Investigaciones Clinicas Argentina -Sanatorio de la Mujer | Rosario | Santa Fe Province | S2000QID | Argentina |
| Centro Medico CCBR Tucuman | San Miguel de Tucumán | Tucumán Province | T4000IAF | Argentina |
| Investigaciones Medicas IMOBA S.R.L. | Buenos Aires | C1179AAB | Argentina |
| Universidad Maimonides | Buenos Aires | C1405BCK | Argentina |
| Centro de Investigacion: AXISMED S.R.L. | Buenos Aires | C1430CKE | Argentina |
| CIPREC - Centro de Investigacion y Prevencion Cardiovascular S.A. | C.a.b.a. | C1119ACN | Argentina |
| Instituto de Cardiologia y Cirugia Cardiovascular - Fundacion Favaloro | Ciudad Autonoma de B. Aires | C1093AAS | Argentina |
| Cicemo - Consultorio de Investigaciones Clinicas E.M.O. S.R.L. | Ciudad Autonoma de B. Aires | C1405BUB | Argentina |
| Instituto Cardiovascular De Buenos Aires | Ciudad Autonoma de B. Aires | C1428ART | Argentina |
| Instituto de Cardiologia de Corrientes "Juana Fca. Cabral" | Corrientes | 3400 | Argentina |
| ILAIM Instituto Latinoamericano de Investigaciones Medicas | Córdoba | X5000BNB | Argentina |
| Clinico Chutro SRL | Córdoba | X5000EPU | Argentina |
| Centro de Investigaciones Clinicas "Instituto del Corazon" | Córdoba | X5000EVQ | Argentina |
| Clinica Privada Colombo | Córdoba | x5002AOQ | Argentina |
| Instituto Medico DAMIC S.R.L. | Córdoba | X5003DCE | Argentina |
| Centro Medico Luquez | Córdoba | X5006IKK | Argentina |
| IPAC Caraffa | Córdoba | X5008KKF | Argentina |
| Hospital Central de Mendoza | Mendoza | 5500 | Argentina |
| Cordis S.A. | Salta | 4400 | Argentina |
| Centro Cardiovascular Salta | Salta | A4406BPF | Argentina |
| Instituto Cardiovascular San Luis A.E. | San Luis | D5702JRS | Argentina |
| Canberra Hospital | Garran | Australian Capital Territory | 2605 | Australia |
| Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders | Camperdown | New South Wales | 2050 | Australia |
| Royal Prince Alfred Hospital | Camperdown | New South Wales | 2050 | Australia |
| Central Coast Neurosciences Research | Erina | New South Wales | 2250 | Australia |
| Gosford Hospital | Gosford | New South Wales | 2250 | Australia |
| Australian Clinical Research Network | Maroubra | New South Wales | 2035 | Australia |
| Royal North Shore Hospital | St Leonards | New South Wales | 2065 | Australia |
| Holy Spirit Northside Private Hospital Limited | Chermside | Queensland | 4032 | Australia |
| Royal Brisbane and Women's Hospital | Herston | Queensland | 4029 | Australia |
| Core Research Group Pty Ltd | Milton | Queensland | 4064 | Australia |
| Redcliffe Hospital | Redcliffe | Queensland | 4020 | Australia |
| Austrials Pty Ltd | Sherwood | Queensland | 4075 | Australia |
| Gold Coast University Hospital | Southport | Queensland | 4215 | Australia |
| Adelaide Medical Research | Ashford | South Australia | 5035 | Australia |
| SA Heart | Ashford | South Australia | 5035 | Australia |
| Southern Adelaide Diabetes and Endocrine Service | Daws Park | South Australia | 5041 | Australia |
| Department of Cardiology, Lyell McEwin Hospital | Elizabeth Vale | South Australia | 5112 | Australia |
| Heart and Vascular Research | Fullarton | South Australia | 5063 | Australia |
| Launceston General Hospital | Launceston | Tasmania | 7250 | Australia |
| Eastern Health - Box Hill Hospital | Box Hill | Victoria | 3128 | Australia |
| The Northern Hospital | Epping | Victoria | 3076 | Australia |
| Barwon Health-The Geelong Hospital | Geelong | Victoria | 3220 | Australia |
| Austin Health - Heidelberg Repatriation Hospital | Heidelberg West | Victoria | 3081 | Australia |
| Alfred Hospital | Melbourne | Victoria | 3004 | Australia |
| Royal Melbourne Hospital | Parkville | Victoria | 3050 | Australia |
| Fremantle Hospital | Fremantle | Western Australia | 6160 | Australia |
| HPS Pharmacies | Joondalup | Western Australia | 6027 | Australia |
| Joondalup Cardiovascular Trials Foundation Inc. | Joondalup | Western Australia | 6027 | Australia |
| Sir Charles Gairdner Hospital, Heart Research Institute | Nedlands | Western Australia | 6009 | Australia |
| VZW Algemeen Ziekenhuis KLINA | Brasschaat | Antwerpen | 2930 | Belgium |
| AZ Turnhout - campus St. Elisabeth | Turnhout | Antwerpen | 2300 | Belgium |
| Hopital Erasme-Universite Libre de Bruxelles (ULB) | Anderlecht | Brabant Flamand | 1070 | Belgium |
| Centre hospitalier de Jolimont-Lobbes - Centre de Recherche Medicale de Jolimont | La Louvière | Haine Saint PAUL | 7100 | Belgium |
| Algemeen Stedelijk Ziekenhuis | Aalst | Oost-vlaanderen | 9300 | Belgium |
| Az Sint Blasius | Dendermonde | Oost-vlaanderen | 9200 | Belgium |
| AZ Sint Lucas Gent-Campus Sint Lucas | Ghent | Oost-vlaanderen | 9000 | Belgium |
| Az Glorieux | Ronse | Oost-vlaanderen | 9600 | Belgium |
| AZ Groeninge-Campus Loofstraat | Kortrijk | West-vlaanderen | 8500 | Belgium |
| Az Damiaan | Ostend | West-vlaanderen | 8400 | Belgium |
| A.Z. Sint-Augustinus Veurne | Veurne | West-vlaanderen | 8630 | Belgium |
| ZNA Campus Middelheim | Antwerp | 2020 | Belgium |
| Imeldaziekenhuis Bonheiden | Bonheiden | 2820 | Belgium |
| A.Z. St.Jan AV Brugge | Bruges | 8000 | Belgium |
| University Hospital Brussels - Centrum voor hart- en vaatziekten | Brussels | 1090 | Belgium |
| University Hospital Brussels- Diabeteskliniek | Brussels | 1090 | Belgium |
| Private Practice 'Cardiovascular Detection Center' | De Pinte | 9840 | Belgium |
| ZOL Campus Sint-Jan | Genk | 3600 | Belgium |
| AZ Maria Middelares | Ghent | 9000 | Belgium |
| Grand Hopital de Charleroi, Site St-Joseph | Gilly | 6060 | Belgium |
| Hygeia | Hasselt | 3500 | Belgium |
| Jessa Ziekenhuis | Hasselt | 3500 | Belgium |
| Sint-Franciskusziekenhuis | Heusden-Zolder | 3550 | Belgium |
| Centre Hospitalier Regional de Huy | Huy | 4500 | Belgium |
| Jan Yperman Ziekenhuis, Cardiology | Ieper | 8900 | Belgium |
| Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg | Leuven | 3000 | Belgium |
| University hospitals Leuven - Cardiology department | Leuven | 3000 | Belgium |
| Centre Hospitalier Chretien | Liège | 4000 | Belgium |
| Centre Hospitalier Universitaire de Liege | Liège | 4000 | Belgium |
| Huisartsenpraktijk Medilink | Linkebeek | 1630 | Belgium |
| Huisartsenpraktijk Luc Capiau | Massemen | 9230 | Belgium |
| AZ Sint-Maarten | Mechelen | 2800 | Belgium |
| C.H.U. Ambroise Pare | Mons | 7000 | Belgium |
| Mariaziekenhuis vzw | Overpelt | 3900 | Belgium |
| AZ Nikolaas | Sint-Niklaas | 9100 | Belgium |
| Dr. Luc De Wolf - Private Practice | Tienen | 3300 | Belgium |
| Centro de Pesquisas em Diabetes e Doencas Endocrino-Metabolicas Ltda | Fortaleza | Ceará | 60430-140 | Brazil |
| Hospital Universitario Walter Cantidio | Fortaleza | Ceará | 60430-370 | Brazil |
| Hospital de Messejana Dr Carlos Alberto Studart Gomes | Fortaleza | Ceará | 60840-285 | Brazil |
| CEDOES - Centro de Diagnostico e Pesquisa da Osteoporose do Espirito Santo | Vitória | Espírito Santo | 29055-450 | Brazil |
| Instituto Cardiopulmonar da Bahia | Salvador | Estado de Bahia | 40170-130 | Brazil |
| Fundacao Bahiana De Cardiologia | Salvador | Estado de Bahia | 41810-010 | Brazil |
| HBA S/A ASSISTENCIA MEDICA E HOSPITALAR-Hospital da Bahia | Salvador | Estado de Bahia | 41810-011 | Brazil |
| Instituto De Cardiologia Do Distrito Federal | Brasília | Federal District | 70658-700 | Brazil |
| INGOH - Instituto Goiano de Oncologia e Hematologia | Goiânia | Goiás | 74093-300 | Brazil |
| Via Medica - Clinica Medica Integrada Ltda - Barroso e Sebba Ltda | Goiânia | Goiás | 74223-130 | Brazil |
| Liga Mineira de Ressuscitacao Cardiopulmonar | Belo Horizonte | Minas Gerais | 30110-021 | Brazil |
| Hospital Lifecenter / Lifecenter Sistema de Saude S.A | Belo Horizonte | Minas Gerais | 30110-921 | Brazil |
| Hospital Felicio Rocho | Belo Horizonte | Minas Gerais | 30110-934 | Brazil |
| Hospital Vera Cruz | Belo Horizonte | Minas Gerais | 30140-062 | Brazil |
| Hospital Universitario Ciencias Medicas / Fundacao Educacional Lucas Machado | Belo Horizonte | Minas Gerais | 30140-073 | Brazil |
| Hospital Universitário Sao José / FELUMA - MG | Belo Horizonte | Minas Gerais | 30140-073 | Brazil |
| Liga Mineira de Ressucitacao cardiopulmonar | Belo Horizonte | Minas Gerais | 30150-320 | Brazil |
| CARDSEARCH/CARDRESEARCH - Cardiologia Assistencial e de Pesquisa LTDA | Belo Horizonte | Minas Gerais | 30150240 | Brazil |
| Universidade Federal de Uberlandia | Uberlândia | Minas Gerais | 38405-320 | Brazil |
| Eurolatino Pesquisas Medicas LTDA | Uberlândia | Minas Gerais | 38411-186 | Brazil |
| Sociedade Hospitalar Angelina Caron/Hospital e Maternidade Angelina Caron | Campina Grande do Sul | Paraná | 83430-000 | Brazil |
| Hospital Santa Casa De Curitiba | Curitiba | Paraná | 80010-030 | Brazil |
| Irmandade da Santa Casa de Misericordia de Curitiba - Hospital Santa Casa de Misericordia | Curitiba | Paraná | 80010-100 | Brazil |
| Quanta Diagnostico e Terapia / Medicina Nuclear Alto da XV | Curitiba | Paraná | 80045-170 | Brazil |
| Nucleo de Pesquisa Clínica | Curitiba | Paraná | 80730-150 | Brazil |
| Hospital Parana - Parana Medical Research Center - MARIMED SERVICOS MEDICOS S.A. | Maringá | Paraná | 87015-000 | Brazil |
| Universidade Federal do Para - Hospital Universitario Joao de Barros Barreto | Belém | Pará | 66073-000 | Brazil |
| Centro de Pesquisas Medicas Basica e Clinica LTDA | Recife | Pernambuco | 52020-010 | Brazil |
| Hospital Agamenon Magalhaes | Recife | Pernambuco | 52051-380 | Brazil |
| CCBR - Centro de Pesquisas e Analises Clinicas LTDA | Rio de Janeiro | Rio de Janeiro | 22271-100 | Brazil |
| CCBR Brasil - Centro de Pesquisa e Analises Clinicas LTDA | Rio de Janeiro | Rio de Janeiro | 22271-100 | Brazil |
| Hemocardio S/S Ltda | Natal | Rio Grande do Norte | 59020-035 | Brazil |
| Hospital Universitario - Associacao Educadora Sao Carlos - AESC | Canoas | Rio Grande do Sul | 92425-055 | Brazil |
| Associacao Hospitalar Beneficente Sao Vicente de Paulo - Hospital Sao Vicente de Paulo | Passo Fundo | Rio Grande do Sul | 99010-080 | Brazil |
| Santa Casa De Misericordia De Pelotas | Pelotas | Rio Grande do Sul | 96015-290 | Brazil |
| Irmandade Da Santa Casa De Misericordia De Porto Alegre - ISCMPA | Porto Alegre | Rio Grande do Sul | 90020-090 | Brazil |
| Hospital de Clinicas de Porto Alegre | Porto Alegre | Rio Grande do Sul | 90035-903 | Brazil |
| Hospital Mae de Deus/Associacao Educadora Sao Carlos AESC/IMV - Instituto de Medicina Vascular | Porto Alegre | Rio Grande do Sul | 90110-270 | Brazil |
| Uniao Brasileira de Educacao e Assistencia (UBEA) - Hospital Sao Lucas da PUCRS | Porto Alegre | Rio Grande do Sul | 90610-000 | Brazil |
| Hospital Santa Isabel | Blumenau | Santa Catarina | 89010-906 | Brazil |
| Insituto de Cardiologia de Santa Catarina | São José | Santa Catarina | 88103-450 | Brazil |
| Loema Medicina e Bem Estar- Centro Especializado em Cardiologia Ltda | Campinas | São Paulo | 13010-001 | Brazil |
| Scentryphar Pesquisa Clinica | Campinas | São Paulo | 13020-431 | Brazil |
| Hospital E Maternidade Celso Pierro PUC - Campinas - Sociedade Campineira de Educacao e Instrucao | Campinas | São Paulo | 13060-904 | Brazil |
| CAEP - Centro Avançado de Estudos e Pesquisas Ltda. | Campinas | São Paulo | 13087-567 | Brazil |
| ICM - Instituto do Coracao de Marilia | Marília | São Paulo | 17515-000 | Brazil |
| Instituto Conceive | Paraíso | São Paulo | 04005-004 | Brazil |
| Hospital Estadual Mario Covas | Santo André | São Paulo | 09190-615 | Brazil |
| Instituto Domingo Braile _ Braile Hospital Dia LTDA | São José do Rio Preto | São Paulo | 15015-750 | Brazil |
| IMC - Instituto de Molestias Cardiovasculares/Equipamentos Cardiovasculares Rio Preto Ltda | São José do Rio Preto | São Paulo | 15015210 | Brazil |
| Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto | São José do Rio Preto | São Paulo | 15090-000 | Brazil |
| CPQuali Pesquisa Clinica LTDA | São Paulo | São Paulo | 01228-000 | Brazil |
| Hospital Samaritano | São Paulo | São Paulo | 01232-010 | Brazil |
| Instituto de Conhecimento, Ensino e Pesquisa (Administrative local) | São Paulo | São Paulo | 01233-000 | Brazil |
| Comed Care Empresa de Atendimento Clinico Geral - LTDA - Hospital Total Care | São Paulo | São Paulo | 01407-200 | Brazil |
| CCBR Sao Paulo | São Paulo | São Paulo | 04062-001 | Brazil |
| CEPIC - Centro Paulista de Investigacao Clinica e Servicos Medicos Ltda. | São Paulo | São Paulo | 04266-010 | Brazil |
| Santa Casa de Misericordia de Votuporanga | Votuporanga | São Paulo | 15500-003 | Brazil |
| CPClin- Centro de Pesquisas Clinicas Ltda./Clinica Dr. Freddy Goldberg Eliaschewitz | São Paulo | 01244-030 | Brazil |
| FGM-Clinica Paulista de Doencas Cardiovasculares | São Paulo | 01327-010 | Brazil |
| SPDM Associacao Paulista para o Desenvolvimento da Medicina | São Paulo | 04024-900 | Brazil |
| UNIFESP - Hospital Sao Paulo - Setor de Lipides, Aterosclerose e Biologia Vascular | São Paulo | 04040-001 | Brazil |
| Instituto Jaqueline Scholz Issa e Mario Issa de Cardiologia LTDA | São Paulo | 05017-000 | Brazil |
| LMC Diabetes & Endocrinology (Calgary) | Calgary | Alberta | T2H 2G4 | Canada |
| Foothills Hospital/University of Calgary | Calgary | Alberta | T2N 4Z6 | Canada |
| Nanji Professional Corporation | Calgary | Alberta | T2V 4J2 | Canada |
| The Medical Arts Health Research Group | Kelowna | British Columbia | V1Y 1V6 | Canada |
| Dr Stephen Pearce Inc | Surrey | British Columbia | V3V 0C6 | Canada |
| Dr. Adam Yeung Inc. | Surrey | British Columbia | V3V 0C6 | Canada |
| Dr. Micheal Kanakos Inc | Surrey | British Columbia | V3V 0C6 | Canada |
| Dr. Raymond Dong Inc. | Surrey | British Columbia | V3V 0C6 | Canada |
| Dr. Richard Bon Inc. | Surrey | British Columbia | V3V 0C6 | Canada |
| Dr. Stephen S. Cheung Inc. | Surrey | British Columbia | V3V 0C6 | Canada |
| SMH Cardiology Clinical Trials | Surrey | British Columbia | V3V 0C6 | Canada |
| Dr Peter K.H. Tan Inc | Surrey | British Columbia | V3V 1N1 | Canada |
| Dr. Dante E. Manyari Inc. | Surrey | British Columbia | V3V 1N1 | Canada |
| Dr. Stephanie Au, Inc. | Surrey | British Columbia | V3V 1N1 | Canada |
| SMH Cardiology Clinical Trials Inc. | Surrey | British Columbia | V3V 1N1 | Canada |
| Dr. Kapil M. Bhagirath Medical Services Corporation | Surrey | British Columbia | V3W 3C3 | Canada |
| Victoria Heart Institute Foundation | Victoria | British Columbia | V8R 4R2 | Canada |
| Discovery Clinical Services Ltd. | Victoria | British Columbia | V8T 5G4 | Canada |
| St. Boniface Hospital | Winnipeg | Manitoba | R2H 2A6 | Canada |
| Unicity Laboratory Services | Winnipeg | Manitoba | R2V 3P4 | Canada |
| Rivergrove Medical Clinic | Winnipeg | Manitoba | R2V 4W3 | Canada |
| G.A. Research Associates Ltd. | Moncton | New Brunswick | E1G 1A7 | Canada |
| Cardiology Research Associates of New Brunswick | Saint John | New Brunswick | E2L 4L2 | Canada |
| Health Sciences Centre | St. John's | Newfoundland and Labrador | A1B 3V6 | Canada |
| LMC Diabetes & Endocrinology (Brampton) | Brampton | Ontario | L6S 0C9 | Canada |
| Aviva Clinical Trial Group Inc. | Burlington | Ontario | L7M 4Y1 | Canada |
| JBN Medical Diagnostic Services Inc. | Burlington | Ontario | L7M 4Y1 | Canada |
| Philippe R. Beaudry Medicine Professional Corporation | Burlington | Ontario | L7R 4E2 | Canada |
| Cambridge Cardiac Care Centre | Cambridge | Ontario | N1R 6V6 | Canada |
| Vizel Cardiac Research, Saul Vizel Professional Medicine Corporation | Cambridge | Ontario | N1R 7R1 | Canada |
| Moran Medical Centre | Collingwood | Ontario | L9Y 1W3 | Canada |
| C & L Research | Fort Erie | Ontario | L2A 1Z3 | Canada |
| Brian Y.L. Wong Medicine Professional Corporation | Greater Sudbury | Ontario | P3E 2N8 | Canada |
| Parkdale Medical Centre | Hamilton | Ontario | L8K 3P3 | Canada |
| Western University - WCPHFM | London | Ontario | N6G 2M1 | Canada |
| Stroke Prevention & Atherosclerosis Research Centre (SPARC)-Siebens-Drake Research Institute | London | Ontario | N6G 2V4 | Canada |
| LMC Diabetes & Endocrinology (Markham) | Markham | Ontario | L6B 0P9 | Canada |
| Newmarket Cardiology Research Group | Newmarket | Ontario | L3Y 8C3 | Canada |
| LMC Clinical Research Inc. (Oakville) | Oakville | Ontario | L6M 1M1 | Canada |
| LMC Oakville | Oakville | Ontario | L6M 1M1 | Canada |
| The Office of Dr. James Cha | Oshawa | Ontario | L1J 2K1 | Canada |
| Kawartha Cardiology Clinical Trials | Peterborough | Ontario | K9J 0B2 | Canada |
| London Road Diagnostic Clinic and Medical Centre | Sarnia | Ontario | N7T 4X3 | Canada |
| Sarnia Institute of Clinical Research | Sarnia | Ontario | N7T 4X3 | Canada |
| Scarborough Cardiology Research Associates Inc. | Scarborough Village | Ontario | M1E 5E9 | Canada |
| Canadian Centre for Research on Diabetes | Smiths Falls | Ontario | K7A 4W8 | Canada |
| LMC Diabetes & Endocrinology (Thornhill) | Thornhill | Ontario | L4J 8L7 | Canada |
| JJ Dig Research LTD | Toronto | Ontario | M3J 1N2 | Canada |
| Canadian Phase Onward, Inc. | Toronto | Ontario | M3J 2C5 | Canada |
| LMC Diabetes & Endocrinology (Bayview) | Toronto | Ontario | M4G 3E8 | Canada |
| Dr. Anil K. Gupta Medicine Professional Corporation | Toronto | Ontario | M9V 4B4 | Canada |
| Dr. Mohan Babapulle Medicine Professional Corporation | Waterloo | Ontario | N2T 0C1 | Canada |
| Dr. Louis Yao | Weston | Ontario | M9N 1W4 | Canada |
| Ecogene-21 | Chicoutimi | Quebec | G7H 7K9 | Canada |
| Q & T Research Chicoutimi | Chicoutimi | Quebec | G7H 7Y8 | Canada |
| Q&T Recherche Outaouais Inc. | Gatineau | Quebec | J8Y 6S8 | Canada |
| Centre de Recherche Clinique de Laval | Laval | Quebec | H7T 2P5 | Canada |
| Omnispec clinical research inc | Mirabel | Quebec | J7J 2K8 | Canada |
| Montreal Heart Institute | Montreal | Quebec | H1T 1C8 | Canada |
| Diex Research Montreal, Inc. | Montreal | Quebec | H2Y 1S1 | Canada |
| Recherche Clinique Sigma Inc | Québec | Quebec | G1G 3Y8 | Canada |
| Clinique des maladies lipidiques de Quebec | Québec | Quebec | G1V 4W2 | Canada |
| Centre integre de sante et de services sociaux de Lanaudiere (CISSSL) | Saint-Charles-Borromée | Quebec | J6E 6J2 | Canada |
| CISSS des Laurentides-Point de Service de St-Jerome- Comite d'ethique de la recherche | Saint-Jérôme | Quebec | J7Z 5T3 | Canada |
| St-Jerome Medical Research Inc. | Saint-Jérôme | Quebec | J7Z 5T3 | Canada |
| LMC Diabetes & Endocrinology (Montreal) | Saint-Laurent | Quebec | H4T 1Z9 | Canada |
| Centre Hospitalier Universitaire de Sherbrooke- Hotel-Dieu | Sherbrooke | Quebec | J1G 2E8 | Canada |
| Centre Integre de Sante et de services sociaux de Chaudiere-Appalaches (CISSS-CA) | St-Georges, Beauce | Quebec | G5Y 4T8 | Canada |
| Centro de Investigacion Clínica del Sur | Temuco | Araucania | 4781156 | Chile |
| Corporacion de Beneficencia Osorno | Osorno | Los Lagos Region | 5311092 | Chile |
| Hospital Clinico Magallanes | Punta Arenas | Region of Magallanes | 6210005 | Chile |
| Biomedica Research Group | Providencia Santiago | Santiago Metropolitan | 7500710 | Chile |
| CICAB | Santiago | Santiago Metropolitan | 7500021 | Chile |
| Servicios Medicos Godoy | Santiago | Santiago Metropolitan | 7500710 | Chile |
| SMOLAM | Santiago | Santiago Metropolitan | 7500739 | Chile |
| Hopsital y CRS El Pino | Santiago | Santiago Metropolitan | 8053095 | Chile |
| Complejo Asitencial Dr. Sotero del Rio | Santiago | Santiago Metropolitan | 8207257 | Chile |
| Quantum Research | Puerto Varas | 5550170 | Chile |
| Guangdong General Hospital | Guangzhou | Guangdong | 510080 | China |
| Haikou People's Hospital | Haikou | Hainan | 570208 | China |
| The 2nd Affiliated Hospital Of Harbin Medical University | Harbin | Heilongjiang | 150001 | China |
| The First Affiliated Hospital of Habrin Medical University | Harbin | Heilongjiang | 150001 | China |
| The First Affiliated Hospital Of Harbin Medical University | Harbin | Heilongjiang | 150001 | China |
| The First Affiliated Hospital Of Zhengzhou University | Zhengzhou | Henan | 450052 | China |
| The Central Hospital Of Wuhan | Wuhan | Hubei | 430014 | China |
| Pu Ai Hospital of Wuhan City | Wuhan | Hubei | 430033 | China |
| Changde First People's Hospital | Changde | Hunan | 415003 | China |
| Changsha Central Hospital | Changsha | Hunan | 410004 | China |
| Hunan Provincial People's Hospital | Changsha | Hunan | 410005 | China |
| Xiangtan City Central Hospital | Xiangtan | Hunan | 411100 | China |
| Zhuzhou Central Hospital | Zhuzhou | Hunan | 412007 | China |
| Inner Mongolia Baogang Hospital | Baotou | Inner Mongolia | 014010 | China |
| Inner Mongolia Autonomous Region People's Hospital | Hohhot | Inner Mongolia | 010017 | China |
| Wuxi People's Hospital | Jiangsu | Jiangsu | 214023 | China |
| Suzhou Kowloon Hospital Shanghai Jiaotong University School of Medicine | Suzhou | Jiangsu | 215021 | China |
| The affiliated Hospital of Xuzhou Medical College | Xuzhou | Jiangsu | 221002 | China |
| Jilin Province People's Hospital | Changchun | Jilin | 130021 | China |
| The First Hospital of Jilin University | Changchun | Jilin | 130021 | China |
| China-Japan Union Hospital of Jilin University | Changchun | Jilin | 130033 | China |
| General Hospital Of Ningxia Medical University | Yinchuan | Ningxia | 750001 | China |
| The Affiliated Hospital of Qingdao University | Qingdao | Shandong | 266003 | China |
| The First Affiliated Hospital Of Xinjiang Medical University | Ürümqi | Xinjiang | 830054 | China |
| Ningbo First hospital | Ningbo | Zhejiang | 315010 | China |
| Beijing Chao-yang Hospital | Beijing | 100020 | China |
| FuWai Hospital, CAMS & PUMC | Beijing | 100037 | China |
| Shanghai General Hospital | Shanghai | 200080 | China |
| Tianjin Union Medical Center | Tianjin | 300120 | China |
| Taizhou Hospital of Zhejiang Province | Zhejiang | 317000 | China |
| Hospital Pablo Tobon Uribe | Medellín | Antioquia | 00000 | Colombia |
| Centro de Investigacion Clinica Avanzada y Multidisciplinaria CICLAM | Medellín | Antioquia | Colombia |
| Centro de Medicina del Ejercicio y Rehabilitacion Cardiac - CEMDE S.A. | Medellín | Antioquia | Colombia |
| Rodrigo Botero S.A.S. | Medellín | Antioquia | Colombia |
| Clinica De La Costa Ltda | Barranquilla | Atlántico | 080020 | Colombia |
| Centro Cientifico Asistencial Jose Luis Accini S.A.S. | Barranquilla | Atlántico | 80020 | Colombia |
| Corazon Ips Sas. | Barranquilla | Atlántico | Colombia |
| Fundacion del Caribe Para La Investigacion Biomedica - Fundacion BIOS | Barranquilla | Atlántico | Colombia |
| Asociacion IPS Medicos Internistas de Caldas | Manizales | Caldas Department | Colombia |
| Hospital Universitario San Ignacio | Bogota D C | Cundinamarca | 00 | Colombia |
| MedPlus Medicina Prepagada S.A. | Bogota D.C. | Cundinamarca | 110911 | Colombia |
| Instituto de Investigacion Endocrinologia y Prevencion Metabolica - ENDOCARE LTDA. | Bogota D.C. | Cundinamarca | Colombia |
| Simedics Ips Sas | Bogota D.C. | Cundinamarca | Colombia |
| Solano & Terront Servicios Medicos Ltda-Establecimiento Comercial UNIENDO | Bogota D.C. | Cundinamarca | Colombia |
| Dexadiab Servicios Medicos LTDA | Bogota D.C | Cundinamarca | 110221 | Colombia |
| Caja de Compensacion Familiar CAFAM, Sede Centro de Atencion en Salud CAFAM FLORESTA | Bogota D.C | Cundinamarca | 111211 | Colombia |
| Healthy Medical Center S.A.S | Zipaquirá | Cundinamarca | 250252 | Colombia |
| Centro de Diagnostico Cardiologico LTDA. | Cartagena | Departamento de Bolívar | Colombia |
| Fundacion Centro de Obesidad y Metabolismo COMETA | Pasto | Departamento de Nariño | Colombia |
| Instituto del Corazon de Bucaramanga S.A. | Bucaramanga | Santander Department | Colombia |
| Fundacion Cardiovascular De Colombia - Instituto del Corazón Floridablanca | Floridablanca | Santander Department | 681004 | Colombia |
| Fundacion Cardiovascular De Colombia - Instituto del Corazón Floridablanca | Floridablanca | Santander Department | Colombia |
| Fundacion Reina Isabel | Cali | Valle del Cauca Department | 760001 | Colombia |
| Edumed S.R.O. | Broumov | Hradec Králové Region | 55001 | Czechia |
| EDUMED s.r.o. | Jaroměř | Hradec Králové Region | 55101 | Czechia |
| Kardiologicka ambulance | Trutnov | Hradec Králové Region | 54101 | Czechia |
| Lekarna na Poliklinice | Trutnov | Hradec Králové Region | 54101 | Czechia |
| Mudr. Jan Vrkoc S.R.O. | Ostrava | Moravian-Silesian Region | 70200 | Czechia |
| Pv-Kardiologie S.R.O. | Pardubice | Pardubice Region | 53002 | Czechia |
| Kardiologicka Ambulance | Brno | South Moravian | 638 00 | Czechia |
| CCBR Czech Brno, s.r.o. | Brno | 602 00 | Czechia |
| DIKa centrum s.r.o., Kardiologicka a interni ambulance | Havířov | 73601 | Czechia |
| Fakultni Nemocnice Hradec Kralove | Hradec Králové | 500 05 | Czechia |
| Fakultni nemocnice Hradec Kralove | Hradec Králové | 50005 | Czechia |
| Fremlova Apotheca s.r.o. | Litovel | 784 01 | Czechia |
| Kardio interna s.r.o. | Litovel | 784 01 | Czechia |
| Fakultni Nemocnice Olomouc | Olomouc | 775 20 | Czechia |
| CCBR Czech a.s. | Pardubice | 530 02 | Czechia |
| Kardiologie Plzen s.r.o. | Pilsen | 326 00 | Czechia |
| Fakultni Nemocnice Kralovske Vinohrady | Prague | 100 34 | Czechia |
| Fakultni poliklinika Vseobecne fakultni nemocnice v Praze | Prague | 128 08 | Czechia |
| CCBR Czech Prague, s.r.o | Prague | 130 00 | Czechia |
| Centrum kardiovaskularni prevence 1. LF UK a TN | Prague | 14059 | Czechia |
| Kardiologie a interni lekarstvi | Prague | 158 00 | Czechia |
| NEFROMED, s.r.o. | Prague | 160 00 | Czechia |
| Interna a kardiologie s.r.o. | Rožnov pod Radhoštěm | 756 61 | Czechia |
| Nemocnice Pardubickeho kraje, a.s., Svitavska nemocnice | Svitavy | 568 25 | Czechia |
| Ordinace V Tabacce s.r.o. | Tábor | 390 02 | Czechia |
| MUDr. Antonin Dufka, kardiologicka ambulance | Uherské Hradiště | 686 01 | Czechia |
| MUDr. Nina Zemkova s.r.o. | Uherské Hradiště | 686 01 | Czechia |
| KIGE s.r.o. | Znojmo | 66902 | Czechia |
| Aabenraa Hospital Hjertemedicinsk klinik Kredslobscentret, SHS | Aabenraa | 6200 | Denmark |
| Sygehus Sonderjylland Aabenraa | Aabenraa | 6200 | Denmark |
| Aalborg Universitetshospital, Lipidklinikken | Aalborg | 9000 | Denmark |
| CCBR Aalborg | Aalborg | 9000 | Denmark |
| Aarhus Universitetshospital Skejby, Hjertesygdomme ¿ Klinisk Forskning | Aarhus | 8200 | Denmark |
| CCBR Ballerup | Ballerup Municipality | DK - 2750 | Denmark |
| Bispebjerg og Frederiksberg Hospital | Copenhagen NV | 2400 | Denmark |
| Sydvestjysk Sygehus, Hjertemedicinsk Projektgruppe | Esbjerg | 6700 | Denmark |
| Frederiksberg Hospital | Frederiksberg | 2000 | Denmark |
| Glostrup Hospital | Glostrup Municipality | 2600 | Denmark |
| Herlev Universitetshospital | Herlev | 2730 | Denmark |
| Regionshospitalet Herning | Herning | 7400 | Denmark |
| Hillerod Hospital | Hillerød | 3400 | Denmark |
| Hvidovre Universitetshospital | Hvidovre | 2650 | Denmark |
| Region Sjaelland Sygehus Nord, Koge Sygehus | Koege | 4600 | Denmark |
| Kolding Sygehus | Kolding | 6000 | Denmark |
| Amager Hospital | København S | 2300 | Denmark |
| Karkirurgisk Klinisk | København Ø | 2100 | Denmark |
| Nykobing F. Sygehus-Medicinsk afdeling | Nykøbing Falster | 4800 | Denmark |
| Region Sjaelland Naestved Sygehus | Næstved | 4700 | Denmark |
| Regionshospitalet Randers | Randers | 8930 | Denmark |
| Regionshospitalet Silkeborg, Hjerte Projektkontor | Silkeborg | 8600 | Denmark |
| Slagelse Sygehus | Slagelse | 4200 | Denmark |
| Svendborg Sygehus | Svendborg | 5700 | Denmark |
| CCBR Vejle | Vejle | DK 7100 | Denmark |
| Hospitalsenheden Midt, Regionshospital Viborg | Viborg | 8800 | Denmark |
| HYKS Jorvin sairaala | Espoo | 02740 | Finland |
| Linnan Klinikka Oy | Hämeenlinna | 13100 | Finland |
| Geri-Med Oy | Helsinki | 00180 | Finland |
| Helsinki University Central Hospital | Helsinki | 00290 | Finland |
| Helsingin yliopistollinen keskussairaala, Sisaetaudit ja kuntoutus, Biomedicum 2U | Helsinki | FI-00290 | Finland |
| Ita-Suomen laakarikeskus Oy | Joensuu | 80100 | Finland |
| StudyCor Oy | Jyväskylä | 40620 | Finland |
| Laeaekaerikeskus Aava Kerava | Kerava | 04200 | Finland |
| Menoa oy | Kinkomaa | 40930 | Finland |
| Kokkolan Keskussairaala | Kokkola | 67200 | Finland |
| Mewell liikuntaklinikka | Kotka | 48600 | Finland |
| Itae-Suomen Laeaekaeritalo | Kuopio | 70100 | Finland |
| Terveystalo Kuopio | Kuopio | 70100 | Finland |
| Oulu Mentalcare Oy | Oulu | 90100 | Finland |
| Terveystalo Oulu, Diapolis | Oulu | 90100 | Finland |
| Oulu University Hospital | Oulu | 90220 | Finland |
| Porin Laakaritalo Oy | Pori | 28100 | Finland |
| Terveystalo Siilinjarvi | Siilinjärvi | 71800 | Finland |
| FinnMedi Oy | Tampere | 33520 | Finland |
| Terveystalo Pulssi | Turku | 20100 | Finland |
| Turku University hospital | Turku | 20520 | Finland |
| Vantaan Tutkimuskeskus | Vantaa | 01600 | Finland |
| Ylitornion Terveyskeskus | Ylitornio | 95600 | Finland |
| CHU Jean Minjoz Cardiologie | Besançon | 25000 | France |
| Groupe Hospitalier de Pellegrin Hopital Pellegrin | Bordeaux | 33076 | France |
| Centre Hospitalier De Bourg En Bresse - Hopital Fleyriat | Bourg-en-Bresse | 01012 | France |
| centre hospitalier Sub-Francilien | Corbeil-Essonnes | 91106 | France |
| Scp Cardiovasculaire De L'Est | Essey-lès-Nancy | 54270 | France |
| Centre Hospitalier Louis Pasteur | Le Coudray | 28630 | France |
| Hopital La Louviere | Lille | 59000 | France |
| Centre Hospitalier Saint Philibert | Lomme | 59462 | France |
| Hopital Cardiovasculaire Et Pneumologique Louis Pradel | Lyon | 69394 | France |
| Hopital Arnaud de Villeneuve - CHU Montpellier | Montpellier | 34295 | France |
| CHU de Nantes - Hopital Nord Laennec | Nantes | 44093 | France |
| Nouvelles Cliniques Nantaises | Nantes | 44200 | France |
| Chu De Nice - Hopital Pasteur | Nice | 06002 | France |
| Hopital Cardiologique | Pessac | 33604 | France |
| CHU de Poitiers | Poitiers | 86021 | France |
| CHU de Renes Hopital de Pontchaillou | Rennes | 35033 | France |
| CHU de Toulouse | Toulouse | 31059 | France |
| Hospital Cuy Chatilliez | Tourcoing | 59200 | France |
| Hopital Trousseau | Tours | 37044 | France |
| Centre Hospitalier (GH) de Valenciennes | Valenciennes | 59300 | France |
| Polyclinique Vauban | Valenciennes | 59300 | France |
| Universitaets Herzzentrum Freiburg Bad Krozingen | Bad Krozingen | Baden-Wurttemberg | 79189 | Germany |
| Medizinische Universitaetsklinik Heidelberg | Heidelberg | Baden-Wurttemberg | 69120 | Germany |
| Gemeinschaftspraxis im Altstadt Carree | Fulda | Hesse | 36037 | Germany |
| Zentrum Klinische Studien Neuwied (ZKSN) | Neuwied | Rhineland-Palatinate | 56564 | Germany |
| Gemeinschaftspraxis Schwabenheim | Schwabenheim | Rhineland-Palatinate | 55270 | Germany |
| Klinikum Altenburger Land Gmbh | Altenburg | 04600 | Germany |
| Forschungszentrum Dr. med Irma Schoell | Bad Homburg | 61348 | Germany |
| Institut fuer Klinische Forschung und Entwicklung(IKFE) Berlin GmbH | Berlin | 10115 | Germany |
| Klinische Forschung Berlin- Mittte GmbH | Berlin | 10117 | Germany |
| POLIKUM Institut GmbH, Polikum Berlin Friedenau | Berlin | 12157 | Germany |
| DRK Kliniken Berlin Kopenick, Zentrum Klinische Forschung | Berlin | 12559 | Germany |
| Synexus Clinical Research GmbH | Berlin | 12627 | Germany |
| Deutsches Herzzentrum Berlin | Berlin | 13353 | Germany |
| Medizinisches Versorgungszentrum am Bahnhof Spandau | Berlin | 13597 | Germany |
| Staedtische Kliniken Bielefeld Gem. GmbH - Klinikum Mitte | Bielefeld | 33604 | Germany |
| Bochum Research Centre-Synexus Clinical Research GmbH | Bochum | 44787 | Germany |
| Synexus Clinical Research GmbH | Bochum | 44787 | Germany |
| MediClin Reha-Zentrum Spreewald | Burg | 03096 | Germany |
| Klinikum Coburg | Coburg | 96450 | Germany |
| Zentrum fuer klinische Forschung | Cologne | 51069 | Germany |
| Kardiologische Praxisgemeinschaft | Dortmund | 44137 | Germany |
| St. Johannes-Hospital | Dortmund | 44137 | Germany |
| Gemeinschaftspraxis fuer Kardiologie Dres. Med. Willgeroth/Wetzel | Dortmund | 44141 | Germany |
| Klinsche Forschung Dresden GmbH | Dresden | 01069 | Germany |
| Praxis Dr. med. Christoph Axthelm | Dresden | 01277 | Germany |
| GWT-TUD GmbH, Studienzentrum Professor Hanefeld | Dresden | 01307 | Germany |
| Gemeinschaftspraxis Dr. Hagemann/Breiderhoff/Durfeld | Essen | 45355 | Germany |
| Medizentrum Essen Borbeck | Essen | 45355 | Germany |
| Studienzentrum | Essen | 45355 | Germany |
| Gemeinschaftspraxis Dres. Dirk Weber, Ulrich Weber, Heiner Saueressig, Birte Turner und Georg | Essen | 45359 | Germany |
| Schwerpunktpraxis Dr. Luedemann fuer Diabetes Gefaess- und Ernaehrungsmedizin | Falkensee | 14612 | Germany |
| Synexus Clinical Research GmbH | Frankfurt | 60313 | Germany |
| Clinphenomics Gmbh & Co Kg, Studienzentrum | Frankfurt | 60594 | Germany |
| IKF Institut fuer klinische Forschung Frankfurt | Frankfurt am Main | 60596 | Germany |
| Klinik und Poliklinik fuer Innere Medizin B - Kardiologie, Angiologie, Pulmologie | Greifswald | 17475 | Germany |
| Cardiologicum Hamburg | Hamburg | 22041 | Germany |
| Praxis Dr. med Cornelia Brauer | Hamburg | 22415 | Germany |
| Klinische Forschung Hannover-Mitte GmbH | Hanover | 30159 | Germany |
| Universitaetsklinikum des Saarlandes Klinik fuer Innere Medizin III | Homburg | 66421 | Germany |
| Praxis Dr. Heister | Kamp-Lintfort | 47475 | Germany |
| Studienzentrum Dr. Appel | Kassel | 34121 | Germany |
| Gemeinschaftspraxis Dr. Klein / Minnich | Künzing | 94550 | Germany |
| Klinik fur Innere Medizin, Kardiologie und Angiologie MediClin Herzzentrum Lahr/Baden. | Lahr | 77933 | Germany |
| Synexus Leipzig Clinical Research Centre | Leipzig | 04103 | Germany |
| SIBAmed Studienzentrum GmbH & Co. KGKG | Leipzig | 04109 | Germany |
| Gemeinschaftspraxis Dr. med. Heidrun Taeschner und Dr. med. Susanne Bonigut | Leipzig | 04249 | Germany |
| Klinikum Leverkusen GgmbH | Leverkusen | 51375 | Germany |
| Klinikum der Stadt Ludwigshafen am Rhein gGmbH | Ludwigshafen | 67063 | Germany |
| Maerkische Kliniken GmbH, Klinikum Luedenscheid, Innere III | Lüdenscheid | 58515 | Germany |
| Klinikum Lunen, St. Marienhospital | Lünen | 44534 | Germany |
| SMO.MD GmbH, Zentrum fuer klinische Studien Site Management and Clinical Research Unit | Magdeburg | 39120 | Germany |
| Pfuetzner Science & Health Institute-Gmbh | Mainz | 55116 | Germany |
| Ze:ro Arztpraxen Dr. med. Salbach | Mannheim | 68165 | Germany |
| Klinikum Fur Herz- & Kreislauferkrankungen | Munich | 80636 | Germany |
| Staedtisches Klinikum Muenchen GmbH, Klinikum Neuperlach | Munich | 81737 | Germany |
| Klinikum Der Universitat Munchen | München | 80336 | Germany |
| Klinikum fuer Herz- & Kreislauferkrankungen | München | 80636 | Germany |
| Kardiologische Praxis Northeim | Northeim | 37154 | Germany |
| Gemeinschaftspraxis Drs Haggenmiller/Jeserich, Kardiologie, Angiologie, Innere Medizin | Nuremberg | 90402 | Germany |
| Allgemeinmedizinisch-Internistische Praxisgemeinschaft | Offenbach | 63071 | Germany |
| Praxis Dres. Med Naudts und Nowack | Rodgau | 63110 | Germany |
| Klinik Am See - Klinik Am See - Rehabilitationszentrum Fur Innere Medizin | Rüdersdorf | 15562 | Germany |
| Klinische Forschung Schwerin GmbH | Schwerin | 19055 | Germany |
| Kardiologische Gemeinschaftspraxis Dres Med. Gerke/Buerger | Soest | 59494 | Germany |
| Praxisgemeinschaft Stuhr-Brinkum | Stuhr-Brinkum | 28816 | Germany |
| Robert-Bosch-Krankenhaus | Stuttgart | 70376 | Germany |
| Universitaetsklinikum Ulm | Ulm | 89081 | Germany |
| Josephs-Hospital Warendorf Med. Klinik II, Kardiologie/Angiologie | Warendorf | 48231 | Germany |
| Kardiologische Praxis | Wermsdorf | 04779 | Germany |
| ForschungszentrumRuhr KliFoCenter GmbH | Witten | 58455 | Germany |
| Pecsi Tudomanyegyetem AOK, II. | Pécs | Baranya | 7624 | Hungary |
| Bacs-Kiskun Megyei Korhaz | Kecskemét | Bács-Kiskun county | 6000 | Hungary |
| Szegedi Tudomanyegyetem AOK, I. sz Belgyogyaszati Klinika | Szeged | Csongrád megye | 6720 | Hungary |
| Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz | Székesfehérvár | Fejér | 8000 | Hungary |
| DRC Kft. | Balatonfüred | 8230 | Hungary |
| DRC Kft. | Balatongyörök | 8313 | Hungary |
| Grof Tisza Istvan Korhaz Berettyoujfalu | Berettyóújfalu | 4100 | Hungary |
| Kardiologiai Maganrendelo | Békéscsaba | 5600 | Hungary |
| Budapesti Szent Ferenc Korhaz | Budapest | 1021 | Hungary |
| Synexus Magyarorszag Kft | Budapest | 1036 | Hungary |
| Szent Rokus Korhaz | Budapest | 1085 | Hungary |
| Semmelweis Egyetem | Budapest | 1088 | Hungary |
| Gottsegen Gyorgy Orszagos Kardiologiai Intezet | Budapest | 1096 | Hungary |
| Egyesitett Szent Istvan es Szent Laszlo Korhaz-Rendelointezet | Budapest | 1097 | Hungary |
| Bajcsy-Zsilinszky Korhaz es Rendelointezet | Budapest | 1106 | Hungary |
| Szent Janos Korhaz es Eszak-budai Egyesitett Korhazak, III. Belgyogyaszat-Kardiologiai Osztaly | Budapest | 1125 | Hungary |
| Debreceni Egyetem, I. sz. Belgyogyaszati Klinika | Debrecen | 4032 | Hungary |
| Synexus Magyarorszag Egeszsegugyi Szolgaltato Kft. | Debrecen | 4032 | Hungary |
| Synexus Magyarorszag Kft. | Gyula | 5700 | Hungary |
| Edes Szivunk Egeszsegkozpont Kft. | Hajdúszoboszló | 4200 | Hungary |
| BKS Research Kft., Albert Schweitzer Korhaz | Hatvan | 3000 | Hungary |
| Somogy Megyei Kaposi Mór Oktató Kórház | Kaposvár | 7400 | Hungary |
| Jutrix Egeszsegugyi Kft | Kecskemét | 6000 | Hungary |
| Pest Megyei Flor ferenc Korhaz | Kistarcsa | 2143 | Hungary |
| Josa Andras Oktatokorhaz | Nyíregyháza | 4400 | Hungary |
| Medifarma-98 Kft. | Nyíregyháza | 4400 | Hungary |
| Pecsi Tudomanyegyetem AOK, I. Belgyogyaszati Klinika | Pécs | 7624 | Hungary |
| Mentahaz Maganorvosi Kozpont | Székesfehérvár | 8000 | Hungary |
| Hetenyi Geza Korhaz | Szolnok | 5000 | Hungary |
| Markusovszky Egyetemi Oktatokarhaz | Szombathely | 9700 | Hungary |
| Dr. Sydo es Tsa Kft | Veszprém | 8200 | Hungary |
| Zala Megyei Korhaz | Zalaegerszeg | 8900 | Hungary |
| Dr. Jivraj Mehta Smarak Health Foundation, Bakeri Medical Research Centre | Ahmedabad | Gujarat | 380007 | India |
| Apex Heart Institute (A Unit of TCVS Pvt. Ltd) | Ahmedabad | Gujarat | 380054 | India |
| SAL Hospital | Ahmedabad | Gujarat | 380054 | India |
| Apple Hospital | Surat | Gujarat | 395 002 | India |
| Unicare Heart Institute & Research Center | Surat | Gujarat | 395002 | India |
| BAPS - Pramukh Swami Hospital | Surat | Gujarat | 395009 | India |
| Rhythm Heart Institute | Vadodara | Gujarat | 390022 | India |
| Aster Aadhar Hospital (Prerana Hospital Ltd.) | Kolhāpur | Maharashtra | 416012 | India |
| Shri Krishna Hrudayalaya and Critical Care Centre | Nagpur | Maharashtra | 440012 | India |
| Jehangir Clinical Development Centre Pvt. Ltd. | Pune | Maharashtra | 411 001 | India |
| Mediciti Hospitals | Hyderabad | Telangana | 500063 | India |
| M.V. Hospital And Research Centre | Lucknow | Uttar Pradesh | 226003 | India |
| Beaumont Hospital | Dublin | Leinster | 9 | Ireland |
| The Adelaide & Meath Hospital-Dublin Incorporating The National Children's Hospital | Dublin | 24 | Ireland |
| Mater Misericordiae University Hospital | Dublin | 7 | Ireland |
| St. James's Hospital | Dublin | 8 | Ireland |
| Health Research Board | Galway | Ireland |
| Portiuncula Hospital | Galway | Ireland |
| Barzilai Medical Center | Ashkelon | 7830604 | Israel |
| Gefen Institute for Research and Cardiac Health | Bat Yam | 5955602 | Israel |
| The Soroka University Medical Center | Beersheba | 84101 | Israel |
| Ben Yair Community Clinic - Clalit Health Services | Beersheba | 84350 | Israel |
| Heart Institute, Hillel Yaffe Medical Center | Hadera | 38100 | Israel |
| Rambam Medical Center | Haifa | 31096 | Israel |
| Cardiovascular Clinical Research Institute | Haifa | 34362 | Israel |
| Edith Wolfson Medical Center | Holon | 58100 | Israel |
| Heart Institute, Bikur Cholim Campus, Shaare Zedek Medical Center | Jerusalem | 91004 | Israel |
| Hadassah Ein Kerem Medical Center | Jerusalem | 91120 | Israel |
| Meir Medical Center | Kfar Saba | 44281 | Israel |
| Galilee Medical Center, Cardiology Department | Nahariya | 22100 | Israel |
| E.M.M.S Nazareth Hospital | Nazareth | 16100 | Israel |
| Rabin Medical Center, Beilinson Hospital | Petah Tikva | 49100 | Israel |
| Rabin Medical Center-Beilinson Hospital | Petah Tikva | 49100 | Israel |
| Rabin Medical Center | Petah Tikva | 49100 | Israel |
| Sha'aria Clinic, Clalit Health Services | Petah Tikva | 4958202 | Israel |
| Shuali Community Clinic, Clalit Health Services | Raanana | 43452 | Israel |
| Department of Neurology & Sagol Neuroscience Center | Ramat Gan | 52621 | Israel |
| Heart Institute, Kaplan Medical Center | Rehovot | 76100 | Israel |
| Kaplan Medical Center | Rehovot | 76100 | Israel |
| Internal Medicine A, Ziv Medical Center | Safed | 13100 | Israel |
| Tel Aviv Sourasky Medical Center | Tel Aviv | 64239 | Israel |
| Assuta Medical Center | Tel Aviv | 6789140 | Israel |
| The Chaim Sheba Medical Center | Tel Litwinsky | 5265601 | Israel |
| A.O. Treviglio e Caravaggio | Treviglio (BG) | Bergamo | 24047 | Italy |
| AOU Policlinico "Mater Domini" UOC di Medicina interna | Catanzaro | CZ | 88100 | Italy |
| Ospedale S. L. Mandic di Merate | Merate | Lecco | 23807 | Italy |
| IRCCS Centro Cardiologico Fondazione Monzino | Milan | MI | 20138 | Italy |
| Ospedale Civile Di Piove Di Sacco | Piove di Sacco | Padova | 35028 | Italy |
| AOU Policlinico "P. Giaccone" Dipartimento delle Patologie Emergenti, Unita di Medicina Interna | Palermo | PA | 90127 | Italy |
| Ospedale S. Maria della Misericordia Dipartimento di Medicina, Medicina Interna, | Perugia | PG | 06132 | Italy |
| Azienda Ospedaliera Della Provincia Di Lecco - Ospedale Manzoni | Lecco | Province OF Lecco | 23900 | Italy |
| Dept."Medicina lnterna e Specialita Mediche" dell' Universita degli | Roma | RM | 00161 | Italy |
| Policlinico Umberto I di Roma | Rome | RM | 00161 | Italy |
| Azienda Ospedaliera S'Andrea di Roma - UOC Cardiologia | Rome | RM | 00189 | Italy |
| Presidioospedaliero di san dona 'di PIAVE | San Dona Di Paive | Venezia | 30027 | Italy |
| Ospedale G. Fracastoro | San Bonifacio | Verona | 37047 | Italy |
| AOUI di Verona - Ospedale Civile Maggiore Borgo Trento | Verona | VR | 37126 | Italy |
| I.N.R.C.A. di Ancona Ospedale Geriatrico | Ancona | 60124 | Italy |
| Ospedale Civile Regionale San Martino, Belluno | Belluno | 32100 | Italy |
| Azienda Ospedaliera G. Brotzu | Cagliari | 09124 | Italy |
| Department of Clinical Medicines and Cardiovascular Sciences, Universita "Federico II" di Napoli | Naples | 80131 | Italy |
| Divisione di Cardiologia con Utic ed Emodinamica - AOU Federico II di Napoli | Naples | 80131 | Italy |
| Divisione di Cardiologia con UTIC ed Emodinamica | Naples | 80131 | Italy |
| A.O. di Reggio Emilia Arcispedale "S. Maria Nuova"/IRCCS | Reggio Emilia | 42123 | Italy |
| AUSL Della Romagna-Ospedale Infermi | Rimini | 47923 | Italy |
| Policlinico Umberto I di Roma - DAI Malattie Cardiovascolari e Respiratorie | Rome | 00161 | Italy |
| Ospedale Santa Maria della Misericordia Azienda ULSS 18 of Rovigo | Rovigo | 45100 | Italy |
| A.O.U. San Giovanni di Dio e Ruggi d'Aragona U.O.C. UTIC | Salerno | 84100 | Italy |
| Azienda Ospedaliera Universitaria Santa Maria Della Misericordia | Udine | 33100 | Italy |
| Consultorio Dr. Leocadio Gerardo Munoz Beltran | Cd. Juarez | Chihuahua | 32472 | Mexico |
| Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares, S.C. | México | D F | 11650 | Mexico |
| Centro de Investigacion Clinica del Pacifico, S.A. de C.V. | Acapulco de Juárez | Guerrero | 39670 | Mexico |
| Investigacion Biomedica Aplicada de Hidalgo S.A. de C.V. | Pachuca | Hidalgo | 42090 | Mexico |
| Centro de Investigacion Medica Integral S.C. | Guadalajara | Jalisco | 44160 | Mexico |
| Instituto de Terapeutica Experimental y Clinica (INTEC) Centro Universitario de Ciencias de la Salud | Guadalajara | Jalisco | 44340 | Mexico |
| Hospital Mexico Americano S.C. (Emergencies) | Guadalajara | Jalisco | 44620 | Mexico |
| Consultorio Privado del Dr. Gabriel Arturo Ramos Lopez | Guadalajara | Jalisco | 44657 | Mexico |
| CICEJ Centro de Investigacion Clinica Endocrinologica de Jalisco SC | Guadalajara | Jalisco | 44670 | Mexico |
| Unidad de Investigacion Clinica y Atencion Medica HEPA S.C. | Guadalajara | Jalisco | 44670 | Mexico |
| Jardines Hospital de Especialidades S.A de C.V | Zapopan | Jalisco | 45040 | Mexico |
| Centro de Atencion e Investigacion en Factores de Riesgo Cardiovascular Omega S.C | Mexico City | Mexico City | 06700 | Mexico |
| Consultorio de Endocrinologia y Nutriologia | Mexico City | Mexico City | 07760 | Mexico |
| Operadora de Hospitales Angeles S.A. de C.V.(Emergencies) | Mexico City | Mexico City | 07760 | Mexico |
| Instituto Nacional de Ciencias Medicas y Nutricion "Salvador Zubiran" | Mexico City | Mexico City | 14000 | Mexico |
| Instituto de Diabetes Obesidad y Nutricion, S.C. | Cuernavaca | Morelos | 62250 | Mexico |
| Hospital Inovamed Cuernavaca (Emergencies) | Cuernavaca | Morelos | 62270 | Mexico |
| Accelerium S. de R.L. de C.V. | Monterrey | Nuevo León | 64000 | Mexico |
| Hospital y Clinica OCA, S.A. de C.V. | Monterrey | Nuevo León | 64000 | Mexico |
| Monterrey International Research Center | Monterrey | Nuevo León | 64000 | Mexico |
| Cardiolink Clin Trials, S.C. | Monterrey | Nuevo León | 64060 | Mexico |
| Hospital Universitario "Dr. Jose Eleuterio Gonzalez" | Monterrey | Nuevo León | 64460 | Mexico |
| Hospital Universitario De Monterrey- "Doctor Jose Eleuterio Gonzalez" | Monterrey | Nuevo León | 64460 | Mexico |
| CRI Centro Regiomontano de Investigacion SC | Monterrey | Nuevo León | 64710 | Mexico |
| Global Trial Research Center S.A. de C.V. | Monterrey | Nuevo León | 64718 | Mexico |
| Fundacion Santos y de la Garza Evia I.B.P. (Centro Medico Zambrano Hellion) | San Pedro Garza García | Nuevo León | 66278 | Mexico |
| Centro Integral Medico SJR S.C | San Juan del Río | Querétaro | 76800 | Mexico |
| Centro para el Desarrollo de la Medicina y de Asistencia Médica Especializada S.C. | Culiacán | Sinaloa | 80020 | Mexico |
| Hospital Angeles Culiacan (Emergencies Only) | Culiacán | Sinaloa | 80020 | Mexico |
| Centro de Estudios de Investigacion Metabolicos y Cardiovasculares S.C. | Tampico | Tamaulipas | 89000 | Mexico |
| Centro de Especialidades Medicas del Estado de Veracruz | Xalapa | Veracruz | 91020 | Mexico |
| Instituto Biomedico De Investigacion A.C. | Aguascalientes | 20127 | Mexico |
| Centro de Investigacion Cardiometabolica de Aguascalientes S.A. de C.V. | Aguascalientes | 20230 | Mexico |
| Centro Hospitalario Mac, S.A. de C.V. (Emergencies) | Aguascalientes | 20230 | Mexico |
| Hospital Cardiologica Aguescalientes | Aguascalientes | 20230 | Mexico |
| Unidad de Investigacion en Salud de Chihuahua S.C. | Chihuahua City | 31203 | Mexico |
| Investigacion en Salud y Metabolismo S.C. | Chihuahua City | 31215 | Mexico |
| Consultorio Medico de Especialidad Dr. Demetrio Kosturakis Garcia | Chihuahua City | 31217 | Mexico |
| Investigacion en Salud y Metabolismo S.C | Chihuahua City | 31217 | Mexico |
| Instituto Nacional de Ciencia Medicas y Nutricion Salvador Zubiran | Distrito Federal | 14000 | Mexico |
| Lahoja Asociacion para la Investigacion y Farmacovigilancia S.C. | Durango | 34000 | Mexico |
| Cardioprevent, S.C. | Durango | 34080 | Mexico |
| Pharmacology and Clinical Research S.A. de C.V. | Querétaro | 76000 | Mexico |
| Cardioarritmias e Investigacion S.C. | San Luis Potosí City | 78200 | Mexico |
| Hospital Lomas de San Luis Intemacional (Emergencies) | San Luis Potosí City | 78218 | Mexico |
| "Hospital Central ""Dr. Ignacio Morones Prieto""" | San Luis Potosí City | 78240 | Mexico |
| Centro Especializado En Diabetes Y Metabolismo | Veracruz | 91910 | Mexico |
| Zuyderland MC | Sittard-Geleen | Limburg | 6162 BG | Netherlands |
| Isala | Zwolle | Overijssel | 8025 AB | Netherlands |
| Tjongerschans Ziekenhuis | Heerenveen | Provincie Friesland | 8441 PW | Netherlands |
| St. Franciscus Gasthuis | Rotterdam | South Holland | 3045 PM | Netherlands |
| Het Lange Land Ziekenhuis | Zoetermeer | South Holland | 2725 NA | Netherlands |
| Noordwest Ziekenhuisgroep | Alkmaar | 1815 JD | Netherlands |
| EB Flevoresearch | Almere Stad | 1311 RL | Netherlands |
| Meander Medical Center | Amersfoort | 3813 TZ | Netherlands |
| Meander Medisch Centrum | Amersfoort | 3813 TZ | Netherlands |
| Amstelland Hospital | Amstelveen | 1186 AM | Netherlands |
| Bovenij Ziekenhuis | Amsterdam | 1034 CS | Netherlands |
| OLVG, locatie West | Amsterdam | 1061 AE | Netherlands |
| VU University Medical Center | Amsterdam | 1081HV | Netherlands |
| Onze Lieve Vrouwe Gasthuis | Amsterdam | 1091 AC | Netherlands |
| Academic Medical Center | Amsterdam | 1105 AZ | Netherlands |
| Gelre Hospitals | Apeldoorn | 7334 DZ | Netherlands |
| Rode Kruis Ziekenhuis | Beverwijk | 1942 LE | Netherlands |
| Tergooi Ziekenhuis | Blaricum | 1261 AN | Netherlands |
| Andro Medical Research B.V. | Breda | 4811 SW | Netherlands |
| Amphia Ziekenhuis | Breda | 4818 CK | Netherlands |
| Reinier de Graaf ziekenhuis | Delft | 2625 AD | Netherlands |
| Deventer Ziekenhuis | Deventer | 7416SE | Netherlands |
| Van Weel Bethesda Hospital | Dirksland | 3247 BW | Netherlands |
| Slingeland Ziekenhuis | Doetinchem | 7009 BL | Netherlands |
| Albert Schweitzer Hospital | Dordrecht | 3318 AT | Netherlands |
| Ziekenhuis Gelderse Vallei | Ede | 6716 RP | Netherlands |
| Andromed Eindhoven | Eindhoven | 5611 NV | Netherlands |
| Heartcentre Catharina Hospital | Eindhoven | 5623 EJ | Netherlands |
| Medisch Spectrum Twente | Enschede | 7512 KZ | Netherlands |
| Beatrix Ziekenhuis | Gorinchem | 4204 AA | Netherlands |
| Groene Hart Ziekenhuis | Gouda | 2803 HH | Netherlands |
| University Medical Center Groningen | Groningen | 9713 GZ | Netherlands |
| Martini Ziekenhuis | Groningen | 9728 NT | Netherlands |
| Spaarne Gasthuis | Haarlem | 2035 RC | Netherlands |
| St. Jansdal Ziekenhuis | Harderwijk | 3844 DG | Netherlands |
| Zuyderland Medisch Centrum | Heerlen | 6419 PC | Netherlands |
| Zuyderland | Heerlen | 6419PC | Netherlands |
| Treant Zorggroep, location Bethesda | Hoogeveen | 7909 AA | Netherlands |
| Vascular Research Centre | Hoorn | 1624 NP | Netherlands |
| Quality Care Research | Kloosterhaar | 7694 AC | Netherlands |
| Medisch Centrum Leeuwarden | Leeuwarden | 8934 AD | Netherlands |
| Leiden University Medical Center | Leiden | 2333 ZA | Netherlands |
| Alrijne Ziekenhuis | Leiden | 2334 CK | Netherlands |
| Alrijne Ziekenhuis | Leiderdorp | 2353 GA | Netherlands |
| GCM Maarssenbroek | Maarssen | 3607 KN | Netherlands |
| Maastricht University Medical Center | Maastricht | 6229 HX | Netherlands |
| Isala Diaconessenhuis | Meppel | 7943 KA | Netherlands |
| St Antonius Hospital | Nieuwegein | 3435 CM | Netherlands |
| Radboud University Nijmegen Medical Centre | Nijmegen | 6525 GA | Netherlands |
| Canisius Wilhelmina Ziekenhuis | Nijmegen | 6532 SZ | Netherlands |
| Waterland Hospital | Purmerend | 1441 RN | Netherlands |
| Andro Medical Research B.V | Rotterdam | 3021 HC | Netherlands |
| Rotterdam Research Institute | Rotterdam | 3039 BD | Netherlands |
| St. Fransiscus Gasthuis | Rotterdam | 3045 PM | Netherlands |
| Ikazia Ziekenhuis | Rotterdam | 3083 AN | Netherlands |
| D&A Research and Genetics | Sneek | 8601 ZR | Netherlands |
| Hedramed | The Hague | 2526 HW | Netherlands |
| Hedramed | The Hague | 2526HW | Netherlands |
| Hagaziekenhuis | The Hague | 2545 CH | Netherlands |
| HMC (Haaglanden Medisch Centrum) Bronovo | The Hague | 2597 AX | Netherlands |
| Ziekenhuis Rivierenland | Tiel | 4002 WP | Netherlands |
| Elisabeth-TweeSteden Ziekenhuis (previously named St. Elisabeth Ziekenhuis) | Tilburg | 5022 GC | Netherlands |
| St. Elisabeth Ziekenhuis | Tilburg | 5022 GC | Netherlands |
| Elisabeth TweeSteden Ziekenhuis (ETZ) | Tilburg | 5042 AD | Netherlands |
| Bernhoven Ziekenhuis | Uden | 5406 PT | Netherlands |
| EB Utrecht | Utrecht | 3511 NH | Netherlands |
| Universitair Medisch Centrum (UMC) Utrecht - Locatie AZU | Utrecht | 3584 CX | Netherlands |
| University Medical Center Utrecht | Utrecht | 3584 CX | Netherlands |
| Maxima Medisch Centrum | Veldhoven | 5504 DB | Netherlands |
| VieCuri Medisch Centrum | Venlo | 5912 BL | Netherlands |
| Twee Steden Ziekenhuis | Waalwijk | 5141 BM | Netherlands |
| Albert Schweitzer Hospital | Zwijndrecht | 3331 LZ | Netherlands |
| Optimal Clinical Trials | Grafton | Auckland | 1010 | New Zealand |
| Henderson Medical Centre | Henderson | Auckland | 0612 | New Zealand |
| Middlemore Hospital | Otahuhu | Auckland | 1640 | New Zealand |
| North Shore Hospital | Takapuna | Auckland | 0622 | New Zealand |
| Hawke's Bay Hospital | Frimley | Hastings | 4120 | New Zealand |
| Auckland City Hospital | Auckland | 1023 | New Zealand |
| Lipid and Diabetes Research Group | Christchurch | 8011 | New Zealand |
| Southern Clinical Trials Shirley Ltd | Christchurch | 8011 | New Zealand |
| Southern Clinical Trials Riccarton | Christchurch | 8041 | New Zealand |
| RMC Medical Research Ltd. | Dunedin | 9012 | New Zealand |
| Taranaki Base Hospital | New Plymouth | 4310 | New Zealand |
| Rotorua Hospital | Rotorua | 3010 | New Zealand |
| Clinical Horizons NZ Ltd. | Tauranga | 3112 New Zealand | New Zealand |
| Clinical Trials Unit,Bay of Plenty(BOP) Clinicla School | Tauranga | 3112 | New Zealand |
| Papamoa Pines Medical Centre | Tauranga | 3118 | New Zealand |
| Clinical Horizons NZ Ltd | Tauranga | 3144 | New Zealand |
| Wellington Hospital | Wellington | 6021 | New Zealand |
| Synexus Polska Sp. z o.o Oddzial w Poznaniu | Poznan | Greater Poland Voivodeship | 60-702 | Poland |
| Nzoz "Twoja Przychodnia" | Poznan | Greater Poland Voivodeship | 61-006 | Poland |
| NZOZ Vitamed | Bydgoszcz | Kuyavian-Pomeranian Voivodeship | 85-079 | Poland |
| Nzoz Centrum Medyczne Kermed | Bydgoszcz | Kuyavian-Pomeranian Voivodeship | 85-231 | Poland |
| Specjalistyczna Praktyka Lekarska Piotr Kubalski | Grudziądz | Kuyavian-Pomeranian Voivodeship | 86-300 | Poland |
| Specjalistyczne Gabinety Lekarskie "Medicor Plus" - Jerzy Kopaczewski | Włocławek | Kuyavian-Pomeranian Voivodeship | 87-800 | Poland |
| Landa Specjalistyczne Gabinety Lekarskie | Krakow | Lesser Poland Voivodeship | 30-015 | Poland |
| Krakowski Szpital Specjalistyczny im. Jana Pawla II | Krakow | Lesser Poland Voivodeship | 31- 202 | Poland |
| Szpital Specjalistyczny im. J. Dietla w Krakowie, Oddzial Kardiologii | Krakow | Lesser Poland Voivodeship | 31-121 | Poland |
| Centrum Medyczne Zdrowa J. Trebacz, W. Zajdel Spolka jawna | Krakow | Lesser Poland Voivodeship | 31-216 | Poland |
| CENTRUM MEDYCZNE A-Z Clinic | Krakow | Lesser Poland Voivodeship | 31-315 | Poland |
| Krakowskie Centrum Medyczne Sp. z o.o. | Krakow | Lesser Poland Voivodeship | 31-501 | Poland |
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie, | Krakow | Lesser Poland Voivodeship | 31-501 | Poland |
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki W Krakowie, Ambulatoria | Krakow | Lesser Poland Voivodeship | 31-531 | Poland |
| NZOZ Centrum Zdrowia i Profilaktyki Dabie Sp. z.o.o. | Krakow | Lesser Poland Voivodeship | 31-567 | Poland |
| Niepubliczny Zaklad Opieki Zdrowotnej Centrum Medyczne ProMiMed sp z o.o., sp.k. | Krakow | Lesser Poland Voivodeship | 31-637 | Poland |
| NeuroCor Banaszkiewicz, Kulaga, Ostrowska, Tomaszewski lekarze spolka partnerska | Myślenice | Lesser Poland Voivodeship | 32-400 | Poland |
| INTERCARD Sp. z. o. o. Centrum Kardiologii Inwazyjnej, Elektroterapii i Angiologii w Nowym Targu | Nowy Targ | Lesser Poland Voivodeship | 34-400 | Poland |
| Medicome Sp. z o.o. | Oświęcim | Lesser Poland Voivodeship | 32-600 | Poland |
| Centrum Szybkiej Diagnostyki Kardiologicznej Kardiomed M. Zabowka E. Zabowka | Tarnów | Lesser Poland Voivodeship | 33-100 | Poland |
| Specjalistyczny Gabinet Lekarski Internistyczno-Kardiologiczny Boguslaw Derlaga | Tarnów | Lesser Poland Voivodeship | 33-100 | Poland |
| Jeleniogorskie Centrum Chorob Serca, Przychodnia Kardiologiczna, Poradnia Kardiologiczna | Jelenia Góra | Lower Silesian Voivodeship | 58-506 | Poland |
| Zdrowie s.c. Agnieszka i Donald Drozdz | Wroclaw | Lower Silesian Voivodeship | 51-314 | Poland |
| Halina Serafin NZOZ Centrum Medyczne SERAFIN-MED | Żarów | Lower Silesian Voivodeship | 58-130 | Poland |
| Clinical Best Solutions | Lublin | Lublin Voivodeship | 20-045 | Poland |
| Optimamed Specjalistyczne Gabinety Lekarskie | Lublin | Lublin Voivodeship | 20-091 | Poland |
| KO-MED Centra Kliniczne Lublin II | Lublin | Lublin Voivodeship | 20-362 | Poland |
| KO-MED Centra Kliniczne Pulawy | Puławy | Lublin Voivodeship | 24-100 | Poland |
| KO-MED Centra Kliniczne Zamosc | Zamość | Lublin Voivodeship | 22-400 | Poland |
| Synexus Polska Sp. z o.o. Oddzial w Katowicach | Katowice | Masovian Voivodeship | 40-040 | Poland |
| Niepubliczny Zaklad Opieki Zdrowotnej Specjalistyczna Przychodnia Lekarska "MEDIKARD" | Płock | Masovian Voivodeship | 09-402 | Poland |
| Centrum Medyczne Piaski Filia nr 9 | Warsaw | Masovian Voivodeship | 01-875 | Poland |
| Instytut Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala Wyszynskiego | Warsaw | Masovian Voivodeship | 02-637 | Poland |
| Wojskowy Instytut Medyczny,Centralny Szpital Kliniczny Ministerstwa Obronty Narodowej | Warsaw | Masovian Voivodeship | 04-141 | Poland |
| Instytut Kardiologii im | Warsaw | Masovian Voivodeship | 04-628 | Poland |
| Specjalistyczny Osrodek Medycyny Wieku Dojrzalego Sp. z o.o. | Warsaw | Masovian Voivodeship | 04-730 | Poland |
| Szpital Specjalistyczny w Brzozowie, Podkarpacki Osrodek Onkologiczny im. Ks. B. Markiewicza Oddzial | Brzozów | Podkarpackie Voivodeship | 36-200 | Poland |
| INTERCARD Sp. z o.o. Centrum Kardiologii Inwazyjnej, Elektroterapii i Angiologii w Krosnie | Krosno | Podkarpackie Voivodeship | 38400 | Poland |
| EMED Centrum Uslug Medycznych Ewa Smialek | Rzeszów | Podkarpackie Voivodeship | 35205 | Poland |
| "OSTEO-MEDIC" s.c. Artur Racewicz, Jerzy Supronik | Bialystok | Podlaskie Voivodeship | 15-351 | Poland |
| Podlaski Osrodek Kardiologii Janusz Korecki | Bialystok | Podlaskie Voivodeship | 15-875 | Poland |
| Synexus Polska Sp. z o.o. Oddzial w Gdansku | Gdansk | Pomeranian Voivodeship | 80-382 | Poland |
| Niepubliczny Zaklad Opieki Zdrowotnej Gdanskie Centrum Zdrowia, Poradnia Kardiologiczna | Gdansk | Pomeranian Voivodeship | 80-542 | Poland |
| Centrum Badan Klinicznych Pi-House, Poradnia Diabetologiczna | Gdansk | Pomeranian Voivodeship | 80-546 | Poland |
| Medica Pro Familia Sp. z o.o. Spolka Komandytowo Akcyjna, Oddzial w Gdyni | Gdynia | Pomeranian Voivodeship | 81-338 | Poland |
| Synexus Polska Sp. z o.o. Oddzial w Gdyni | Gdynia | Pomeranian Voivodeship | 81-384 | Poland |
| NZOZ "PRO CORDIS" Sopockie Centrum Badan Kardiologicznych | Gdynia | Pomeranian Voivodeship | 81-423 | Poland |
| Gabinet Kardiologiczno - lnternistyczny | Gdynia | Pomeranian Voivodeship | 81-472 | Poland |
| Centrum Medyczne "SOPMED" Sp. z o.o. | Sopot | Pomeranian Voivodeship | 81-756 | Poland |
| Indywidualna Specjalistyczna Praktyka Lekarska Malgorzata Biedrzycka | Starogard Gdański | Pomeranian Voivodeship | 83-200 | Poland |
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej Wojewodzki Szpital Specjalistyczny Nr 4 w Bytomiu | Bytom | Silesian Voivodeship | 41-902 | Poland |
| Bogna Gabrylewicz Andrzej Ochala Unimed s.c. | Katowice | Silesian Voivodeship | 40-083 | Poland |
| Pro Familia Altera Poradnia Wielospecjalistyczna | Katowice | Silesian Voivodeship | 40-648 | Poland |
| NZOZ Terapia Optima | Katowice | Silesian Voivodeship | 40-752 | Poland |
| Przychodnia Specjalistyczna Samodzielny Publiczny ZOZ w Rudzie Slaskiej, | Ruda Śląska | Silesian Voivodeship | 41-709 | Poland |
| NZOZ "Medyk"Sp. z o. o. | Wola | Silesian Voivodeship | 43-225 | Poland |
| Wojewodzki Szpital Zespolony w Elblagu, Oddzial Kardiologiczny z Pododdzialem Kardiologii Inwazyjnej | Elblag | Warmian-Masurian Voivodeship | 82-300 | Poland |
| Specjalistyczny Osrodek Leczniczo-Badawczy Zbigniew Zegota | Ostróda | Warmian-Masurian Voivodeship | 14-100 | Poland |
| Centrum Medyczne AMED | Warsaw | WOJ Mazowieckie | 01-518 | Poland |
| Marek Piepiorka Gabinet Kardiologiczno - lnternistyczny | Gdynia | 81-472 | Poland |
| Nzoz Gall-Med | Krakow | 30-053 | Poland |
| NZOZ Centrum Zdrowia i Profilaktyki Dabie Sp. z.o.o. | Krakow | 31-567 | Poland |
| "TWOJA PRZYCHODNIA" Sp. Z o.o | Lublin | 20-857 | Poland |
| Medicus w Opolu Sp z o. o. | Opole | 45-706 | Poland |
| Centrum Zdrowia Metabolicznego Pawel Bogdanski | Poznan | 60-592 | Poland |
| NZOZ PRZYCHODNIA SPECJALISTYCZNA Andrzej Wittek Henryk Rudzki s.c. | Ruda Śląska | 41-709 | Poland |
| KO-MED Centra Kliniczne Staszow | Staszów | 28-200 | Poland |
| Synexus Polska Sp. z o.o. Oddzial w Warszawie | Warsaw | 01-192 | Poland |
| Centrum Medyczne Warszawskiego Uniwersytetu Medycznego Sp. z o.o | Warsaw | 02-097 | Poland |
| Instytut Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala Wyszynskiego Klinika Kardiologii | Warsaw | 04-628 | Poland |
| Synexus Polska Sp. z o.o. Oddzial we Wroclawiu | Wroclaw | 50-088 | Poland |
| Centrum Opieki Diabetologiczno-Endokrynologicznej i Ginekologiczno-Polozniczej | Wroclaw | 50-306 | Poland |
| Dobrostan Michal Bogacki | Wroclaw | 53-301 | Poland |
| Gabinet Lekarski Malgorzata Saryusz-Wolska | Lodz | Łódź Voivodeship | 90-132 | Poland |
| Specjalistyczny Osrodek Medycyny Wieku Dojrzalego Sp. z o.o. Jednostka 02 | Lodz | Łódź Voivodeship | 90-368 | Poland |
| "Prywatny Gabinet Kardiologiczny" Dr N.Med. Maciej Kosmider | Lodz | Łódź Voivodeship | 91-490 | Poland |
| Niepubliczny Zaklad Opieki Zdrowotnej CEREO-MED Sp. z o.o. | Lodz | Łódź Voivodeship | 92-003 | Poland |
| SPZOZ Centralny Szpital Kliniczny Uniwersytetu Medycznego w Lodzi 251 Pomorska | Lodz | Łódź Voivodeship | 92-213 | Poland |
| Prywatny Gabinet Lekarski Dr n. med. Michal Ogorek | Piotrkow Trybunalski | Łódź Voivodeship | 97-300 | Poland |
| Centrum Medyczne Ogrodowa Sp. z o.o. | Skierniewice | Łódź Voivodeship | 96-100 | Poland |
| Prywatny Gabinet Lekarski Marianna Janion | Kielce | Świętokrzyskie Voivodeship | 25-315 | Poland |
| Endocrine Lipid Diabetes Research Institute | Ponce | PR | 00717 | Puerto Rico |
| Miguel Sosa-Padilla, MD-Private Practice | San Juan | PR | 00926-2832 | Puerto Rico |
| Centro de Diabetes para Puerto Rico | San Juan | PR | 00935 | Puerto Rico |
| The Office of Roberto J. Ayala-Rios, MD - Research Center and Private Practice (DMRA LLC) | Anasco | 00610 | Puerto Rico |
| Cardiometabolic Research Center, Inc. | Ponce | 00717 | Puerto Rico |
| Consultorio Medico Figueroa | San Juan | 00917 | Puerto Rico |
| Pradnet Inc. | San Juan | 00917 | Puerto Rico |
| Altamira Family Medicine And Research Institute | San Juan | 00920 | Puerto Rico |
| Pitesti-Arges County Emergency Hospital | Piteşti | Argeş | 110084 | Romania |
| Medical Practice SRL | Oradea | Bihor County | 410032 | Romania |
| County Clinical Emergency Hospital Oradea | Oradea | Bihor County | 410169 | Romania |
| County Emergency Hospital Deva | Deva | Hunedoara County | 330084 | Romania |
| Centrul Medical Sf. Stefan | Timișoara | JUD. Timis | 300125 | Romania |
| Dr. Pop Calin Florin - Cabinet Cardiologie | Baia Mare | Maramureş | 430130 | Romania |
| Podoleanu G. Cristian-Gheorghe-Calin - Cardiology Medical Practice | Târgu Mureş | Mureș County | 540143 | Romania |
| Diabmed Dr. Popescu Alexandrina SRL, Diabet, Nutritie, Boli Metabolice | Ploieşti | Prahova | 100163 | Romania |
| Dr. Busegeanu Mihaela Private Practice | Ploieşti | Prahova | 100342 | Romania |
| Institute of Cardiovascular Diseases Timisoara | Timișoara | Timiș County | 300310 | Romania |
| Euromedica Hospital | Baia Mare | 430032 | Romania |
| S.C. Polimed Dacia S.R.L. | Brasov | 500209 | Romania |
| Centrul Medical de Diagnostic si Tratament Ambulator Neomed | Brasov | 500283 | Romania |
| Spitalul Clinic Judetean De Urgenta Braila(Braila County Clincal Emergency Hospital) | Brăila | 810249 | Romania |
| Data Plus Medical Clinic | Bucharest | 010192 | Romania |
| Spitalul Universitar De Urgenta Militar Central, Dr. Carol Davila | Bucharest | 010825 | Romania |
| "Prof. Dr. N.C. Paulescu" National Institute of Diabetes, Nutrition and Metabolic Diseases, | Bucharest | 020045 | Romania |
| Spitalul Clinic Colentina, Departament Cardiologie | Bucharest | 020125 | Romania |
| SC Clinica Medicala Synexus SRL, Medicina Interna | Bucharest | 021611 | Romania |
| SC Centrul Medical Policlinico Di Monza SRL, Cardiologie | Bucharest | 021967 | Romania |
| SC Policlinica CCBR SRL | Bucharest | 030463 | Romania |
| Med Plus SRL (Med Plus Ltd.) | Bucharest | 061118 | Romania |
| S.C. Centrul Medical "Sanatatea Ta" S.R.L. | Bucharest | 20614 | Romania |
| Spitalul Clinic Judetean de Urgenta Cluj-Napoca, Diabet Zaharat, Nutritie si Boli Metabolice | Cluj-Napoca | 400006 | Romania |
| Dr. Mistodie Cristina Victoria MD, Office of | Galati | 800098 | Romania |
| S.C. Diamed Obesity S.R.L. | Galati | 800291 | Romania |
| County Emergency Hospital Satu Mare Diabetes, Nutrition And Metabolic Diseases Department | Satu Mare | 440055 | Romania |
| County Clinical Emergency Hospital Sibiu | Sibiu | 550245 | Romania |
| Cardio Med SRL | Târgu Mureş | 540124 | Romania |
| Centrul Medical Dr. Negrisanu SRL, Diabet Zaharat, Nutritie si Boli Metabolice | Timișoara | 300456 | Romania |
| State Budgetary Healthcare Institution "Research Institution - Regional Clinical Hospital #1 | Krasnodar | Krasnodarskiy Kray | 350086 | Russia |
| State Budgetary Healthcare Institution Of Moscow Region "Lubertsy Regional Hospital #2" | Lubertsy | Moscow Oblast | 140006 | Russia |
| Federal State Budgetary Institution of Healthcare Hospital of Russian Academy of Sciences | Troitsk | Moscow Oblast | 142190 | Russia |
| State Budgetary Institution "Ryazan Regional Clinical Hospital" | Ryazan | Ryazan Oblast | 390039 | Russia |
| Saint Petersburg State Budgetary Institution of Healthcare Municipal hospital | Saint Petersburg | Sestroretsk | 197706 | Russia |
| FSBEI of HE Kazan State Medical University on the base of SBHI Clinical Hospital No.2 | Kazan' | Tatarstan Republic | 420033 | Russia |
| SBEI of HPE Kazan State Medical University on the base of SBHI Clinical Hospital No.2 | Kazan' | Tatarstan Republic | 420033 | Russia |
| Municipal Budgetary State Healthcare Institution "City Clinical Hospital #6" | Chelyabinsk | 454047 | Russia |
| Non-State Institution of Healthcare "Railway Clinical Hospital at station Chelyabinsk of open | Chelyabinsk | 454092 | Russia |
| State Budgetary Healthcare Institution "Region Clinical Hospital #3" | Chelyabinsk | 454136 | Russia |
| Regional Budgetary Healthcare Institution "Cardiology Dispensary" | Ivanovo | 153012 | Russia |
| State Budgetary Institution of Healthcare of Kaluga Region "Kaluga Regional Hospital" | Kaluga | 428007 | Russia |
| Federal State Budgetary Educational Institution of Higher Education "Kazan State Medical University" | Kazan' | 420012 | Russia |
| State Autonomous Healthcare Institution | Kazan' | 420064 | Russia |
| "SAHI of Kemerovo ""Regional Clinical Hospital of Emergency Medical Care n.a. M.A Podgorbunsky """ | Kemerovo | 650000 | Russia |
| Municipal Budgetary Institution of Healthcare | Kemerovo | 650000 | Russia |
| Federal state budgetary institution Research institute of complex problems | Kemerovo | 650002 | Russia |
| FSHI "Medical and Sanitary Unit of the Ministry of Internal Affairs of Russia across Kemerovo region | Kemerovo | 650099 | Russia |
| Kirov Regional State Budgetary Healthcare Institution "Kirov City Clinical Hospital #1" | Kirov | 610014 | Russia |
| Regional Budgetary Healthcare Institution "Kursk City Clinical Emergency Hospital" | Kursk | 305035 | Russia |
| Non-State Institution of Healthcare "Central Clinical Hospital #6 OAO "RZhD" | Moscow | 109388 | Russia |
| Federal State Budgetary Institution "State Research Center for Preventive Medicine" of the Ministry | Moscow | 109990 | Russia |
| SBHI of Moscow city "City Clinical Hospital #15 n.a. O.M. Filatova" | Moscow | 111539 | Russia |
| SBEI of HPE I. M. Sechenov First Moscow State Medical University, UKB #2 | Moscow | 119435 | Russia |
| State Healthcare Institution "City Clinical Hospital #51 of Healthcare Department of Moscow City" | Moscow | 121309 | Russia |
| Federal State Budgetary Institution "Central Clinical Hospital with Polyclinic" | Moscow | 121359 | Russia |
| Federal State Budgetary Institution "Russian Cardiology Research And Production Complex" Of Ministry | Moscow | 121552 | Russia |
| Russian Cardiology Research And Production Complex of Ministry of Health of Russian Federation | Moscow | 121552 | Russia |
| Moscow State Healthcare Institution "City clinical hospital n.a. S.P.Botkin" | Moscow | 125284 | Russia |
| SBIH "City Clinical Hospital #81 Departments of Healthcare of Moscow" | Moscow | 127644 | Russia |
| Federal State Budget Institution "Out-patient Clinic #3" of Russian Federation, | Moscow | 129090 | Russia |
| State Regional Budgetary Healthcare Institution | Murmansk | 183047 | Russia |
| State Budgetary Healthcare Institution of Nizhegorodskaya Region | Nizhny Novgorod | 603076 | Russia |
| Federal State Budgetary Institution "Research Institute of Therapy and Preventive Medicine" of | Novosibirsk | 630089 | Russia |
| SBRIHPE "Novosibirsk State Medical University" of MHSD of RF | Novosibirsk | 630091 | Russia |
| "Reafan" LLC | Novosibirsk | 630099 | Russia |
| "SBHI of Novosibirsk ""City Clinical Hospital of Emergency Medical Care # 2""" | Novosibirsk | 630102 | Russia |
| Municipal Budgetary Institution of Healthcare of Novosibirsk | Novosibirsk | 630102 | Russia |
| State Budgetary Institution of Healthcare of Novosibirsk region City Clinical Hospital of Emergency | Novosibirsk | 630102 | Russia |
| State Budgetary Institution of Healthcare"Penzenskaya Regional clinical hospital n.a N.N Burdenko" | Penza | 440026 | Russia |
| SBHI of Saint-Petersburg "City Hospital # 38 n.a. N.A. Semashko" | Pushkin | 196601 | Russia |
| Federal State Budgetary Educational Institution of Higher Education | Rostov-on-Don | 344022 | Russia |
| State Budgetary Educational Institution Of Higher Professional Education | Rostov-on-Don | 344022 | Russia |
| State Budgetary Educational Institution of Higher Professional Education | Rostov-on-Don | 344068 | Russia |
| Limited Liability Company International Medical Centre SOGAZ | Saint Petersburg | 191186 | Russia |
| Saint-Petersburg State Budgetary Institution of Healthcare "City Hospital #23" | Saint Petersburg | 192148 | Russia |
| Saint-Petersburg State Budgetary Healthcare Institution "City Alexandrovskaya Hospital" | Saint Petersburg | 193312 | Russia |
| Federal state budget institution of healthcare Saint-Petersburg clinical hospital of Russian Academy | Saint Petersburg | 194017 | Russia |
| Limited Liability Company "Reavita" | Saint Petersburg | 194354 | Russia |
| "Limited Liability Company ""Institute of Medical Research""" | Saint Petersburg | 196084 | Russia |
| Limited Liability Company "Institute of Medical research" | Saint Petersburg | 196084 | Russia |
| LLC "Institution of medical studies" | Saint Petersburg | 196084 | Russia |
| City Hospital # 38 n.a. Semashko | Saint Petersburg | 196601 | Russia |
| Federal State Budgetary Educational Institution of Higher Education | Saint Petersburg | 197022 | Russia |
| SBEI of HPE "First Pavlov State Medical University of St. Petersburg" of the MOH of the RF | Saint Petersburg | 197022 | Russia |
| Federal State Budgetary Institution "Advisory Diagnostic Center and Polyclinic" | Saint Petersburg | 197110 | Russia |
| Federal State Budgetary Institution | Saint Petersburg | 197341 | Russia |
| Saint-Petersburg State Budgetary Healthcare Institution "City Hospital #15" | Saint Petersburg | 198205 | Russia |
| State Budgetary Healthcare Institution "Samara Regional Clinical Cardiology Dispensary" | Samara | 443070 | Russia |
| MHI "City Clinical Hospital #12" of the Healthcare Committee | Saratov | 410039 | Russia |
| State Institution of Healthcare "Regional Clinical Hospital" | Saratov | 410053 | Russia |
| State Budget Educational Institution of Higher Professional Education | Smolensk | 214019 | Russia |
| Tyumen Cardiology Research Center-branch of the Tomsk NRMC | Tomsk | 634009 | Russia |
| GBOU VPO Siberian State Medical University Ministry of Healthcare of the Russian Federation | Tomsk | 634050 | Russia |
| State Budgetary Educational Institution of Highest Professional Education "Siberian State Medical | Tomsk | 634050 | Russia |
| State Autonomous Institution of Healthcare of the Tyumen region Tyumen Institute of Therapy | Tyumen | 625000 | Russia |
| Affiliate of the Federal State Budgetary Institution Scientific Research Institute of Cardiology | Tyumen | 625026 | Russia |
| State Autonomous Healthcare Institution of Yaroslavl region | Yaroslavl | 150003 | Russia |
| FSBEI of HE "Yaroslavl State Medical University" MH of the Russian Federation | Yaroslavl | 150010 | Russia |
| State Budgetary Healthcare Institution of Yaroslavl Region "Clinical Hospital No. 10" | Yaroslavl | 150023 | Russia |
| State Healthcare Institution of Yaroslavl Region "Clinical Hospital #8" | Yaroslavl | 150030 | Russia |
| Municipal Autonomous Institution "City Clinical Hospital #14" | Yekaterinburg | 620039 | Russia |
| Nemocnica Ruzinov-Univerzitna Nemocnica Bratislava (UNB) | Bratislava | Bratislava Region | 826 06 | Slovakia |
| Stredoslovensky Ustav Srdcovych A Cievnych Chorob A.S. | Banská Bystrica | 974 01 | Slovakia |
| Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica | Banská Bystrica | 975 17 | Slovakia |
| Alian s.r.o., kardiologicka ambulancia | Bardejov | 08501 | Slovakia |
| METABOL KLINIK s. r.o., Ambulancia pre diabetologiu, poruchy latkovej premeny a vyzivy | Bratislava | 811 08 | Slovakia |
| Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto, l.intema klinika | Bratislava | 81369 | Slovakia |
| Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto, l.interna klinika | Bratislava | 81369 | Slovakia |
| Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto | Bratislava | 81369 | Slovakia |
| UN Bratislava, Nemocnica Ruzinov, V. interna klinika LFUK a UN Bratislava | Bratislava | 826 06 | Slovakia |
| Kardiovaskularne centrum s.r.o. | Bratislava | 83101 | Slovakia |
| Metabolicke centrum MUDr. Katariny Raslovej, s.r.o. | Bratislava | 83101 | Slovakia |
| Narodny ustav srdcovych a cievnych chorob, a.s. | Bratislava | 833 48 | Slovakia |
| Univerzitna Nemocnica Bratislava | Bratislava | 83305 | Slovakia |
| Narodny ustav srdcovych a cievnych chorob, a.s. | Bratislava | 83348 | Slovakia |
| KARDIO-SANUS spol., s.r.o. | Bratislava | 84108 | Slovakia |
| UN Bratislava Nemocnica Sv. Cyrila a Metoda, kardiologicka ambulancia 1 | Bratislava | 851 07 | Slovakia |
| VERIA, s.r.o. -Kardiologicka ambulancia | Bratislava | 85101 | Slovakia |
| Endiamed s.r.o. Nestatna diabetologicka a endokrinologicka ambulancia | Dolný Kubín | 02601 | Slovakia |
| JM-Interna s.r.o., interna ambulancia | Dolný Kubín | 02601 | Slovakia |
| CARDIO D&R s.r.o. , Kardiologicka ambulancia | Košice | 040 01 | Slovakia |
| AGTO., spol. s r. o. | Košice | 04011 | Slovakia |
| Cardio D&R spol.s.r.o., Kardiologicka ambulancia | Košice | 04022 | Slovakia |
| Medicentrum Heart, Spol. S.R.O | Kráľovský Chlmec | 077 01 | Slovakia |
| CELL-B s.r.o. interna ambulancia | Levice | 93405 | Slovakia |
| Liptovska nemocnica s poliklinikou MUDr.Ivana Stodolu Liptovsky Mikulas | Liptovský Mikuláš | 031 23 | Slovakia |
| KARDIO 1 s.r.o. | Lučenec | 984 39 | Slovakia |
| Klinika hematologie a transfuziologie, Univerzitna nemocnica Martin | Martin | 03659 | Slovakia |
| MEDI M&M s.r.o., Ambulancia vnutorneho lekarstva | Moldava nad Bodvou | 045 01 | Slovakia |
| MUDr. Kanderkova s.r.o., Diabetologicka ambulancia | Námestovo | 02901 | Slovakia |
| Kardiocentrum Nitra s.r.o., kardiologicka ambulancia | Nitra | 94901 | Slovakia |
| Fakultna Nemocnica s poliklinikou Nove Zamky | Nové Zámky | 940 34 | Slovakia |
| Mediab s.r.o. Diabetologicka ambulancia | Pezinok | 90201 | Slovakia |
| BENIMED s.r.o. | Piešťany | 921 01 | Slovakia |
| Medispol S.R.O. | Prešov | 08001 | Slovakia |
| Medilex s.r.o. Interna ambulancia | Rimavská Sobota | 979 01 | Slovakia |
| Kardioamb s.r.o. | Rimavská Sobota | 97901 | Slovakia |
| DIAMEL, s.r.o., Diabetologicka ambulancia | Trenčín | 911 01 | Slovakia |
| BV Medical, s.r.o. Diabetologicka ambulancia, | Trnava | 917 01 | Slovakia |
| Kardiologicka ambulancia | Trnava | 917 01 | Slovakia |
| Medivasa, s.r.o. | Žilina | 010 01 | Slovakia |
| Nash Ranjith Research Centre | Merebank | Durban | 4052 | South Africa |
| IATROS International | Bloemfontein | Free State | 9301 | South Africa |
| JOSHA Research | Bloemfontein | Free State | 9301 | South Africa |
| Welkom Clinical trial Centre | Welkom | Free State | 9460 | South Africa |
| Midrand Medical Centre | Halfway House | Gauteng | 1685 | South Africa |
| Sunward Park Hospital | Johannesburg | Gauteng | 1459 | South Africa |
| Sunninghill Hospital | Johannesburg | Gauteng | 2157 | South Africa |
| I Engelbrecht Research (Pty) Ltd | Lyttelton | Gauteng | 0157 | South Africa |
| Charlotte Maxeke Johannesburg Academic Hospital | Parktown | Gauteng | 2193 | South Africa |
| Medipark Centre for Clinical Research | Pretoria | Gauteng | 0158 | South Africa |
| Synexus Watermeyer Clinical Research Centre | Pretoria | Gauteng | 0184 | South Africa |
| Jongaie Research | Pretoria West | Gauteng | 0183 | South Africa |
| Roodepoort Medicross Clinical Research Centre | Roodepoort | Gauteng | 1724 | South Africa |
| Wits Clinical Research | Soweto | Gauteng | 2013 | South Africa |
| Medi-Clinic Heart Hospital | Sunnyside | Gauteng | 0083 | South Africa |
| Sunninghill Hospital | Sunninghill | Johannesburg | 2191 | South Africa |
| Glastonbury Medical Research Centre | Durban | KwaZulu-Natal | 4001 | South Africa |
| Suite 502 | Durban | KwaZulu-Natal | 4001 | South Africa |
| Dr Ganesh c/o Dr NB Maharaj | Durban | KwaZulu-Natal | 4091 | South Africa |
| Limpopo Clinical Research Initiative | Thabazimbi | Limpopo | 0380 | South Africa |
| Zinakekele Medical centre | Moloto South | Mpumalanga | 1022 | South Africa |
| Drs Joynt Venter & Associates | Witbank (eMalahleni) | Mpumalanga | 1035 | South Africa |
| Dr JM Engelbrecht Trial Site-Vergelegen Mediclinic | Cape Town | Western Cape | 7130 | South Africa |
| Tiervlei Trial Centre | Cape Town | Western Cape | 7530 | South Africa |
| Synopsis Research cc | Cape Town | Western Cape | 7700 | South Africa |
| Helderberg Research Institute | Somerset West | Western Cape | 7130 | South Africa |
| Synexus Helderberg Clinical Research Centre | Somerset West | Western Cape | 7130 | South Africa |
| Global Clinical Trials (Pty) Ltd. | Arcadia, Pretoria | 0001 | South Africa |
| Unitas Hospital | Centurion | 0157 | South Africa |
| Clinresco Centres (Pty) Ltd-Central Professional Suits | Gauteng | 1619 | South Africa |
| Centre For Diabetes And Endocrinology | Johannesburg | 2198 | South Africa |
| Paarl Research Centre | Paarl | 7646 | South Africa |
| TREAD Research cc | Parow | 7500 | South Africa |
| Clinical Projects Research SA (Pty) Ltd | Worcester | 6850 | South Africa |
| Chungbuk National University Hospital | Cheongju-si | Chungcheonbuk-do | 28644 | South Korea |
| Kangwon National University Hospital | Chuncheon | Gangwon-do | 24289 | South Korea |
| Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital | Wŏnju | Gangwon-do | 26426 | South Korea |
| Dongguk University Ilsan Hospital | Goyang-si | Gyeonggi-do | 10326 | South Korea |
| Inje University Ilsan Paik Hospital | Goyang-si | Gyeonggi-do | 10380 | South Korea |
| MyongJi Hospital | Goyang-si | Gyeonggi-do | 10475 | South Korea |
| Seoul National University Bundang Hospital | Seongnam-si | Gyeonggi-do | 13620 | South Korea |
| Ajou University Hospital | Suwon | Gyeonggi-do | 16499 | South Korea |
| Uijeongbu St. Mary's Hospital-The Catholic University of Korea | Uijeongbu-si | Gyeonggi-do | 11765 | South Korea |
| Inha University Hospital | Jung-gu | Incheon | 400-711 | South Korea |
| Hallym University Kangdong Sacred Heart Hospital | Seoul | Korea, Republic of | 05355 | South Korea |
| Inje University Busan Paik Hospital | Busan | 47392 | South Korea |
| Dong-A University Hospital | Busan | 49201 | South Korea |
| Daegu Catholic University Medical Center | Daegu | 42472 | South Korea |
| Konyang University Hospital | Daejeon | 302-718 | South Korea |
| Daejeon St. Mary's Hospital-The Catholic University of Korea | Daejeon | 34943 | South Korea |
| Chonnam National University Hospital | Gwangju | 61469 | South Korea |
| Gachon University Gil Medical Center | Incheon | 21565 | South Korea |
| Gangnam Severance Hospital, Yonsei University Health System | Seoul | 06273 | South Korea |
| SMG-SNU Boramae Medical Center | Seoul | 07061 | South Korea |
| Asan Medical Center | Seoul | 138-736 | South Korea |
| Hospital Clinico Universitario de Santiago de Compostela | Santiago de Compostela | A Coruna | 15706 | Spain |
| Hospital Universitario de Santiago de Compostela | Santiago de Compostela | A Coruna | 15706 | Spain |
| Hospital Virgen De Los Lirios | Alcoy | Alicante | 03804 | Spain |
| Hospital General Comarcal de Elda Virgen de la Salud | Elda | Alicante | 03600 | Spain |
| Hospital Regional Universitario de Malaga | Málaga | Andalusia | 29010 | Spain |
| Hospital Universitario Virgen del Rocio | Seville | Andalusia | 41013 | Spain |
| Hospital Comarcal d'Inca | Inca | Balearic Islands | 07300 | Spain |
| Clinica Juaneda | Palma de Mallorca | Balearic Islands | 07014 | Spain |
| Hospital Son Llatzer | Palma de Mallorca | Balearic Islands | 07198 | Spain |
| Cap Florida | L'Hospitalet de Llobregat | Barcelona-cataluna | 08905 | Spain |
| Hospital General de Granollers | Granollers | Barcelona/cataluña | 08400 | Spain |
| Hospital Universitari de Bellvitge | L'Hospitalet de Llobregat | Barcelona | 08907 | Spain |
| Hospital Universitario de Bellvitge | L'Hospitalet de Llobregat | Barcelona | 08907 | Spain |
| CAP La Mina | Sant Adrià de Besòs | Barcelona | 08930 | Spain |
| EAP Vic | Vic | Barcelona | 08500 | Spain |
| Hospital Universitario de Cruces | Barakaldo | Basque Country | 48903 | Spain |
| Hospital Universitario Marques de Valdecilla | Santander | Cantabria | 39008 | Spain |
| Institut Catala De La Salut - Hospital Universitari Arnau De Vilanova (Huav) | Lleida | Catalonia | 25198 | Spain |
| Hospital Universitari de Tarragona Joan XXIII | Tarragona | Catalonia | 43007 | Spain |
| Albera Salut | Peralada | Gerona | 17491 | Spain |
| Hospital De Figueres | Figueres | Girona-catalonia | 17600 | Spain |
| Hospital Arquitecto Marcide | Ferrol | LA Coruna | 15405 | Spain |
| H. U. Principe de Asturias | Alcalá de Henares | Madrid | 28805 | Spain |
| Hospital Principe de Asturias | Alcalá de Henares | Madrid | 28805 | Spain |
| Hospital Universitario Principe de Asturias | Alcalá de Henares | Madrid | 28805 | Spain |
| Hospital Universitario Fundacion Alcorcon | Alcorcón | Madrid | 28922 | Spain |
| Hospital Universitario Puerta de Hierro - Majadahonda | Majadahonda | Madrid | 28222 | Spain |
| Hospital Universitario Puerta de Hierro | Majadahonda | Madrid | 28222 | Spain |
| Complejo Hospitalario de Navarra | Pamplona | Navarre | 31008 | Spain |
| Consultorio de Colloto | Colloto | Oviedo Asturias | 33010 | Spain |
| Centro de Salud El Cristo | Oviedo | Principality of Asturias | 33006 | Spain |
| Centro Salud Paulino Prieto | Oviedo | Principality of Asturias | 33009 | Spain |
| Hospital Universitario Sant Joan de Reus | Reus | Tarragona | 43204 | Spain |
| Hospital General de Requena | Requena | Valencia | 46340 | Spain |
| Hospital Universitario San Juan de Alicante | San Juan de Alicante (Alicante) | Valencia | 03550 | Spain |
| Hospital Abente y Lago | A Coruña | 15001 | Spain |
| Complejo Hospitalario Universitario A Coruna | A Coruña | 15006 | Spain |
| Complejo Hospitalario Universitario de Albacete | Albacete | 02006 | Spain |
| Hospital General Universitario de Alicante; Servicio Cardiologia | Alicante | 03010 | Spain |
| Hospital Virgen del Mar | Almería | 04120 | Spain |
| Parc de Salut mar ¿ Hospital del Mar | Barcelona | 08003 | Spain |
| Parc De Salut Mar-Hospital Del Mar | Barcelona | 08003 | Spain |
| Centre Teknon | Barcelona | 08022 | Spain |
| EAP Sardenya | Barcelona | 08025 | Spain |
| Hospital de la Santa Creu i Sant pau | Barcelona | 08025 | Spain |
| Hospital Universitari Vall d'Hebron | Barcelona | 08035 | Spain |
| CAP Centelles | Barcelona | 08540 | Spain |
| Fundacio Hospital de I'Esperit Sant | Barcelona | 08923 | Spain |
| Cap Disset De Setembre (Sant Cosme I Sant Damia) | Barcelona/Cataluna | 08820 | Spain |
| Hospital General De Granollers | Barcelona/Cataluña | 08400 | Spain |
| H. General Universitario de Ciudad Real | Ciudad Real | 13005 | Spain |
| Hospital Universitario Reina Sofia | Córdoba | 14004 | Spain |
| Complexo Hospitalario Universitario Arquitecto Marcide-Profesor Novoa Santos De Ferrol | Ferrol | 15401 | Spain |
| Hospital Universitario San Cecilio de Granada | Granada | 18012 | Spain |
| Hospital Universitario Virgen de las Nieves (HUVN) | Granada | 18014 | Spain |
| Hospital Universitari Arnau de Vilanova | Lleida | 25198 | Spain |
| Hospital Universitario Lucus Augusti | Lugo | 27003 | Spain |
| Hospital Universitario de La Princesa | Madrid | 28006 | Spain |
| Hospital General Universitario Gregorio Maranon | Madrid | 28007 | Spain |
| Hospital Carlos III | Madrid | 28029 | Spain |
| Hospital Universitario Ramon y Cajal | Madrid | 28034 | Spain |
| Fundacion Jimenez Diaz | Madrid | 28040 | Spain |
| Hospital Universitario Fundacion Jimenez Diaz | Madrid | 28040 | Spain |
| Hospital Universitario La Paz; Unidad Metabolico-Vascular | Madrid | 28046 | Spain |
| Hospital Universitario Quiron Madrid | Madrid | 28223 | Spain |
| Hospital Universitario Virgen de la Victoria | Málaga | 29006 | Spain |
| Hospital Regional Universitario de Malaga | Málaga | 29009 | Spain |
| Hospital Universitario Virgen De La Victoria | Málaga | 29010 | Spain |
| Hospital General Universitario Morales Meseguer | Murcia | 30008 | Spain |
| Clinica Nuevas Tecnologias en Diabetes y Endocrinologia | Seville | 41003 | Spain |
| Hospital Universitario Virgen Macarena | Seville | 41009 | Spain |
| Hospital Universitario Virgen del Rocio | Seville | 41013 | Spain |
| Hospital Universitario Virgen de Valme | Seville | 41014 | Spain |
| CAP Muralles | Tarragona | 43002 | Spain |
| Hospital General Universitario de Valencia | Valencia | 46014 | Spain |
| Hospital Alvaro Cunqueiro (Hospital Meixoerio) | Vigo | 36312 | Spain |
| Hospital Clinico Universitario Miguel Servet; Medicina Interna | Zaragoza | 50009 | Spain |
| Karolinska Universitetssjukhuset Huddinge | Stockholm | Huddinge | 141 86 | Sweden |
| Kasernens Läkarservice AB | Eksjö | 57535 | Sweden |
| Clinical Trial Center (CTC)/Centrum foer klinisk proevning | Gothenburg | 413 45 | Sweden |
| Centrum for klinisk provning-Sahlgrenska Universitetssjukhus | Gothenburg | 41345 | Sweden |
| Sahlgrenska Universitetssjukhuset | Gothenburg | 41345 | Sweden |
| Pharmasite AB | Helsingborg | 25220 | Sweden |
| Centralsjukhuset Karlstad | Karlstad | 65185 | Sweden |
| Centralsjukhuset Kristianstad | Kristianstad | 291 85 | Sweden |
| Capio Citykliniken Hjartmottagning | Lund | 221 21 | Sweden |
| Probar E Lund AB | Lund | 222 22 | Sweden |
| Karlkliniken, Skanes Universitetssjukhus i Malmo | Malmö | 205 02 | Sweden |
| Pharmasite | Malmö | 211 52 | Sweden |
| Forskningsenheten, Medicinmottagningen Sahlgrenska Universitetssjukhuset/Molndal, Hus J | Mölndal | 431 80 | Sweden |
| Ostersunds Sjukhus | Östersund | 83183 | Sweden |
| Dalecarlia Clinical Research Center | Rättvik | 79530 | Sweden |
| Skelleftea Lasarett | Skellefteå | 93186 | Sweden |
| Citydiabetes | Stockholm | 111 57 | Sweden |
| Karolinska Trial Alliance, KTA Prim | Stockholm | 113 24 | Sweden |
| Södersjukhuset Ab | Stockholm | 118 83 | Sweden |
| Karolinska Universitetssjukhuset | Stockholm | 17176 | Sweden |
| Hjartkliniken | Stockholm | 188 82 | Sweden |
| Akademiska Sjukhuset | Uppsala | 75185 | Sweden |
| Vastmanlands Sjukhus Vasteras | Västerås | 721 89 | Sweden |
| Diagene Laboratories | Reinach | Basel Switzerland | 4153 | Switzerland |
| Universitatsspital | Basel | Canton of Basel-City | 4031 | Switzerland |
| Centre Hospitalier Universitaire Vaudois (CHUV) | Lausanne | Canton of Vaud | 1011 | Switzerland |
| Policlinique Medicale Universitaire | Lausanne | Canton of Vaud | 1011 | Switzerland |
| Kantonsspital Winterthur | Winterthur | Canton of Zurich | 8401 | Switzerland |
| Fondazione Diabete Lugano | Lugano | Canton Ticino | 6900 | Switzerland |
| Hopitaux Universitaires de Geneve | Geneva | 1211 | Switzerland |
| Luzerner Kantonsspital Luzern | Lucerne | CH-6000 | Switzerland |
| Cardiocentro Ticino | Lugano | CH-6900 | Switzerland |
| Kantonsspital St. Gallen | Sankt Gallen | CH-9007 | Switzerland |
| China Medical University Hospital | Taichung | Taiwan R O C | 40447 | Taiwan |
| Chung Shan Medical University Hospital | Taichung | Taiwan ROC | 40201 | Taiwan |
| Kaohsiung Medical University Chung-Ho Memorial Hospital - New | Kaohsiung City | 807 | Taiwan |
| National Cheng Kung University (NCKU) Hospital | Tainan | 70403 | Taiwan |
| National Cheng Kung University Hospital | Tainan | 70403 | Taiwan |
| National Taiwan University Hospital | Taipei | 10002 | Taiwan |
| MacKay Memorial Hospital | Taipei | 10449 | Taiwan |
| Taipei Veterans General Hospital | Taipei | 11217 | Taiwan |
| Division of Cardiology, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol | Bangkoknoi | Bangkok | 10700 | Thailand |
| Clinical Research Center, Phramongkutklao Hospital | Rajathevee | Bangkok | 10400 | Thailand |
| Endocrine Unit, Department of Medicine, Phramongkutklao Hospital | Rajathevee | Bangkok | 10400 | Thailand |
| Cardiology Unit, Department of Medicine, Faculty of Medicine,Ramathibodi Hospital,Mahidol University | Ratchathewi | Bangkok | 10400 | Thailand |
| Division of Cardiology, Department of medicine,Faculty of Medicine, Srinagarind Hospital, Khon Kaen | Muang | Changwat Khon Kaen | 40002 | Thailand |
| Division of Cardiology, Department of Medicine, Faculty of Medicine, Songklanagarind Hospital, | Hat Yai | Changwat Songkhla | 90110 | Thailand |
| Heart Center, Songklanagarind Prince of Songkla University | Hat Yai | Changwat Songkhla | 90110 | Thailand |
| Division Of cardiology,Department of Medicine,Faculty Of Medicine,Chulalongkorn University | Bangkok | 10400 | Thailand |
| Dokuz Eylul Univesitesi Tip Fakultesi Hastanesi | Izmir | Ankara | 35340 | Turkey (Türkiye) |
| Baskent University, Adana Yuregir Training & Research Hospital | Adana | 01250 | Turkey (Türkiye) |
| A.karahisar Kocatepe Universitesi Hastanesi Ahmet Necdet Sezer Uygulama ve Arastirma Hastanesi | Afyonkarahisar | 03200 | Turkey (Türkiye) |
| Diskapi Yildirim Beyazit Egitim ve Arastirma Hastanesi | Ankara | 06110 | Turkey (Türkiye) |
| Akdeniz Universitesi Tip Fakultesi Hastanesi | Antalya | 07058 | Turkey (Türkiye) |
| Akdeniz Universitesi Tip Fakultesi | Antalya | 07059 | Turkey (Türkiye) |
| Antalya Training & Research Hospital | Antalya | 07100 | Turkey (Türkiye) |
| Bursa Yuksek Ihtisas Egitim ve Arastirma Hastanesi | Bursa | 16320 | Turkey (Türkiye) |
| Gaziantep Universitesi Tip Fakultesi Sahinbey Egitim ve Arastirma Hastanesi | Gaziantep | 27310 | Turkey (Türkiye) |
| Bezmialem Vakif Universitesi Tip Fakultesi Kardiyoloji Anabilim Dali | Istanbul | 34093 | Turkey (Türkiye) |
| Bezmialem Vakif Universitesi Tip Fakultesi Kardiyoloji Bolumu | Istanbul | 34093 | Turkey (Türkiye) |
| Istanbul Universitesi Istanbul Tip Fakultesi | Istanbul | 34093 | Turkey (Türkiye) |
| Istanbul Universitesi Kardiyoloji Enstitusu | Istanbul | 34096 | Turkey (Türkiye) |
| Yeditepe University School of Medicine | Istanbul | 34752 | Turkey (Türkiye) |
| Ege University, School of Medicine | Izmir | 35100 | Turkey (Türkiye) |
| Dokuz Eylul Universitesi Tip Fakultesi | Izmir | 35340 | Turkey (Türkiye) |
| Kocaeli University School Of Medicine-Kocaeli Universitesi Tip Fakultesi | Kocaeli | 41380 | Turkey (Türkiye) |
| Dumlupinar Universitesi Kutahya Evliya Celebi EAH | Kütahya | 43100 | Turkey (Türkiye) |
| Mersin University, School of Medicine | Mersin | 33343 | Turkey (Türkiye) |
| Recep Tayyip Erdogan University School of Medicine, Training & Research Hospital | Rize | 53020 | Turkey (Türkiye) |
| Synexus Thames Valley Clinical Research Centre | Reading | Berkshire | RG2 0TG | United Kingdom |
| Westongrove Research Centre | Aylesbury | Buckinghamshire | HP22 5LB | United Kingdom |
| Peterborough City Hospital | Peterborough | Cambridgeshire | PE3 9GZ | United Kingdom |
| Morrab Surgery | Penzance | Cornwall | TR18 4EL | United Kingdom |
| Brannel Surgery | St Austell | Cornwall | PL26 7RL | United Kingdom |
| The Michael White Centre for Diabetes & Endocrinology, Hull Royal Infirmary | Hull | EAST Yorkshire | HU3 2RW | United Kingdom |
| Queen's Hospital | Romford | Essex | RM7 0AG | United Kingdom |
| Synexus Manchester Clinical Research Centre-Manchester Science Park | Manchester | Greater Manchester | M15 6SX | United Kingdom |
| Royal Oldham Hospital | Oldham | Greater Manchester | OL1 2JH | United Kingdom |
| St Francis Surgery | Chandlers Ford | Hampshire | SO53 2ZH | United Kingdom |
| Lister Hospital | Stevenage | Hertfordshire | SG1 4AB | United Kingdom |
| East and North Hertfordshire NHS Trust | Welwyn Garden City | Hertfordshire | AL7 4HQ | United Kingdom |
| Howlands Clinic - Queen Elizabeth II Hospital | Welwyn Garden City | Hertfordshire | AL7 4HQ | United Kingdom |
| Synexus Scotland Clinical Research Centre | Glasgow | Lanarkshire | G20 0SP | United Kingdom |
| Layton Medical Centre | Blackpool | Lancashire | FY3 7EN | United Kingdom |
| Synexus Lancashire Clinical Research Centre | Chorley | Lancashire | PR7 7NA | United Kingdom |
| Salford Royal NHS Foundation Trust - Dermatology Centre | Salford | M6 8HD | M6 8HD | United Kingdom |
| Synexus Merseyside Clinical Research Centre | Liverpool | Merseyside | L22 0LG | United Kingdom |
| The Royal Liverpool and Broadgreen -University Hospitals NHS Trust | Liverpool | Merseyside | L78XP | United Kingdom |
| Whitby Group Practice | Whitby | North Yorkshire | YO21 1SD | United Kingdom |
| Albany House Medical Centre | Wellingborough | Northants | NN84RW | United Kingdom |
| Southern Health & Social Care Trust, Craigavon Area Hospital | Portadown | Northern Ireland | BT63 5QQ | United Kingdom |
| Synexus North East Clinical Research Centre - Hexham General Hospital | Hexham | Northumberland | NE46 1QJ | United Kingdom |
| South Axholme Practice | Doncaster | South Yorkshire | DN9 2HY | United Kingdom |
| Central Manchester University Hospitals NHS Foundation Trust | Manchester | South Yorkshire | M13 9WL | United Kingdom |
| The Crouch Oak Family Practice | Addlestone | Surrey | KT15 2BH | United Kingdom |
| Ely Bridge Surgery | Cardiff | Wales | CF5 4AD | United Kingdom |
| Synexus Midlands Clinical Research Centre | Birmingham | WEST Midlands | B15 2SQ | United Kingdom |
| City Hospital | Birmingham | WEST Midlands | B18 7QH | United Kingdom |
| Heart of England NHS Trust | Birmingham | WEST MIDS | B9 5SS | United Kingdom |
| Prince Philip Hospital | Llanelli | WEST Wales | SA14 8QF | United Kingdom |
| Royal Free London NHS Foundation Trust | Barnet | EN5 3DJ | United Kingdom |
| Royal Victoria Hospital | Belfast | BT12 6BA | United Kingdom |
| Laurie Pike Health Centre | Birmingham | B6 6BB | United Kingdom |
| Heart of England NHS Foundation Trust, Dept. of Clinical Biochemistry & Immunology | Birmingham | B9 5SS | United Kingdom |
| Royal Bolton Hospital - Bolton Nhs Foundation Trust | Bolton | BL4 0JR | United Kingdom |
| Synexus Wales Clinical Research Centre | Cardiff | CF14 5GJ | United Kingdom |
| Ashgate Medical Practice | Chesterfield | S404AA | United Kingdom |
| Conquest Hospital - East Sussex Healthcare NHS Trust | East Sussex | TN37 7RD | United Kingdom |
| Little Common Surgery | East Sussex | TN39 4SP | United Kingdom |
| Sea Road Surgery | East Sussex | TN40 1JJ | United Kingdom |
| Staploe Medical Centre | Ely | CB7 5JD | United Kingdom |
| The Queen Elizabeth University Hospital- NHS Greater Glasgow and Clyde | Glasgow | G51 4TF | United Kingdom |
| McGlone Practice Baillieston Health Centre | Glasgow | G69 7AD | United Kingdom |
| Burbage Surgery | Hinckley | LE10 2SE | United Kingdom |
| William Harvey Heart Centre (WHHC) | London | EC1M 6BQ | United Kingdom |
| Royal Free Hospital | London | NW3 2QG | United Kingdom |
| Peart-Rose Research Unit, Hammersmith Hospital, Imperial College NHS Trust | London | W12 OHS | United Kingdom |
| The Red Porto cabin, The James Cook University Hospital | Middlesbrough | TS4 3BW | United Kingdom |
| St Mary's Hospital | Newport | PO30 5TG | United Kingdom |
| Wansford And Kings Cliffe Practice | Peterborough | PE8 6PL | United Kingdom |
| Rothwell and Desborough Healthcare Group | Rothwell, Northants | NN14 6JQ | United Kingdom |
| Abertawe Bro Morgannwg University Local Health Board | Swansea | SA2 8PP | United Kingdom |
| Western Sussex Hospitals NHS Trust | Worthing | BN11 2DH | United Kingdom |
| York Medical Group | York | YO30 6AE | United Kingdom |
| Strensall Healthcare Centre | York | YO32 5UA | United Kingdom |
| 29685591 | Derived | Ridker PM, Rose LM, Kastelein JJP, Santos RD, Wei C, Revkin J, Yunis C, Tardif JC, Shear CL; Studies of PCSK9 Inhibition and the Reduction of vascular Events (SPIRE) Investigators. Cardiovascular event reduction with PCSK9 inhibition among 1578 patients with familial hypercholesterolemia: Results from the SPIRE randomized trials of bococizumab. J Clin Lipidol. 2018 Jul-Aug;12(4):958-965. doi: 10.1016/j.jacl.2018.03.088. Epub 2018 Apr 3. |
| 28304242 | Derived | Ridker PM, Revkin J, Amarenco P, Brunell R, Curto M, Civeira F, Flather M, Glynn RJ, Gregoire J, Jukema JW, Karpov Y, Kastelein JJP, Koenig W, Lorenzatti A, Manga P, Masiukiewicz U, Miller M, Mosterd A, Murin J, Nicolau JC, Nissen S, Ponikowski P, Santos RD, Schwartz PF, Soran H, White H, Wright RS, Vrablik M, Yunis C, Shear CL, Tardif JC; SPIRE Cardiovascular Outcome Investigators. Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients. N Engl J Med. 2017 Apr 20;376(16):1527-1539. doi: 10.1056/NEJMoa1701488. Epub 2017 Mar 17. |
Participants received single dose of PF-04950615 150 milligrams, subcutaneous injection once every 2 weeks for upto 3 years. Participants were followed up to 40 days after the last dose.
| Treated |
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| COMPLETED |
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| NOT COMPLETED |
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Full analysis set (FAS): all participants who were randomized, excluding who attempted to be randomized more than once into a bococizumab cardiovascular (CV) outcomes trial (B1481022/B1481038) or attempted to be randomized in more than 1 CV outcomes trial and all participants enrolled at study Site 3027 where a quality-related event was identified.
Not provided
| ID | Title | Description |
|---|---|---|
| BG000 | Placebo | Participants received single dose of placebo matched to PF-04950615 subcutaneous injection once every 2 weeks for upto 3 years. Participants were followed up to 40 days after the last dose. |
| BG001 | Bococizumab (PF-04950615) | Participants received single dose of PF-04950615 150 milligrams, subcutaneous injection once every 2 weeks for upto 3 years. Participants were followed up to 40 days after the last dose. |
| BG002 | Total | Total of all reporting groups |
| Units | Counts |
|---|---|
| Participants |
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| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean | Standard Deviation | Years |
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| Sex: Female, Male | Count of Participants | Participants |
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| Ethnicity (NIH/OMB) | Count of Participants | Participants |
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| Race (NIH/OMB) | Count of Participants | Participants |
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| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Primary | Event Rate Per 100 Participant-Years For First Occurrence of Major Cardiovascular (CV) Event | Event rate per 100 participant-years for first occurrence of major CV event (adjudicated by Adjudication Committee) was reported. Major CV event was defined as any of the following: CV death (defined as sudden cardiac death, fatal myocardial infarction [MI], death due to heart failure, death due to stroke [fatal ischemic stroke or fatal stroke of undetermined etiology], or death due to other cardiovascular causes) non-fatal MI, non-fatal stroke, and hospitalization for unstable angina needing urgent revascularization. Event rate was calculated as the number of events per 100 participant-years at risk. | Full analysis set (FAS): all participants who were randomized, excluding who attempted to be randomized more than once into a bococizumab CV outcomes trial (B1481022/B1481038) or attempted to be randomized in more than 1 CV outcomes trial and all participants enrolled at study Site 3027 where a quality-related event was identified. | Posted | Number | 95% Confidence Interval | Events Per 100 Participant-Years | From baseline until the date of first adjudicated and confirmed occurrence of major CV event (maximum duration: up to 3.4 years) |
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| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Composite Endpoint of Cardiovascular Death, Non-Fatal Myocardial Infraction, or Non-Fatal Stroke | Event rate per 100 participant-years for first occurrence of composite endpoint of CV death, non-fatal MI or non-fatal stroke (adjudicated by Adjudication Committee) was reported. Cardiovascular death was defined as sudden cardiac death, fatal MI, death due to heart failure, death due to stroke (fatal ischemic stroke or fatal stroke of undetermined etiology), or death due to other cardiovascular causes. Event rate was calculated as the number of events per 100 participant-years at risk. | FAS: all participants who were randomized, excluding who attempted to be randomized more than once into a bococizumab CV outcomes trial (B1481022/B1481038) or attempted to be randomized in more than 1 CV outcomes trial and all participants enrolled at study Site 3027 where a quality-related event was identified. | Posted | Number | 95% Confidence Interval | Events Per 100 Participant-Years | From baseline until the date of first adjudicated and confirmed occurrence of the CV death, non-fatal MI or non-fatal stroke (maximum duration: up to 3.4 years) |
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| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Composite Endpoint of All-Cause Death, Non-Fatal Myocardial Infraction, Non-Fatal Stroke, or Hospitalization for Unstable Angina Needing Urgent Revascularization | Event rate per 100 participant-years for first occurrence of composite endpoint of all-cause death, non-fatal MI, non-fatal stroke, or hospitalization for unstable angina needing urgent revascularization (adjudicated by Adjudication Committee) was reported. All-cause death was defined as the death due to any cause during the course of study. Event rate was calculated as the number of events per 100 participant-years at risk. | FAS: all participants who were randomized, excluding who attempted to be randomized more than once into a bococizumab CV outcomes trial (B1481022/B1481038) or attempted to be randomized in more than 1 CV outcomes trial and all participants enrolled at study Site 3027 where a quality-related event was identified. | Posted | Number | 95% Confidence Interval | Events Per 100 Participant-Years | From baseline until the date of first adjudicated and confirmed occurrence of all-cause death, non-fatal MI, non-fatal stroke, or hospitalization for unstable angina needing urgent revascularization (maximum duration: up to 3.4 years) |
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| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Composite Endpoint of All-Cause Death, Non-Fatal Myocardial Infarction, or Non-Fatal Stroke | Event rate per 100 participant-years for first occurrence of composite endpoint of all-cause death, non-fatal MI, or non-fatal stroke (adjudicated by adjudication committee) was reported. All-cause death was defined as the death due to any cause during the course of study. Event rate was calculated as the number of events per 100 participant-years at risk. | FAS: all participants who were randomized, excluding who attempted to be randomized more than once into a bococizumab CV outcomes trial (B1481022/B1481038) or attempted to be randomized in more than 1 CV outcomes trial and all participants enrolled at study Site 3027 where a quality-related event was identified. | Posted | Number | 95% Confidence Interval | Events Per 100 Participant-Years | From baseline until the date of first adjudicated and confirmed occurrence of the all-cause death, non-fatal MI, or non-fatal stroke (maximum duration: up to 3.4 years) |
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| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Hospitalization for Unstable Angina Needing Urgent Revascularization | Event rate per 100 participant-years for first occurrence of hospitalization for unstable angina needing urgent revascularization (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | FAS: all participants who were randomized, excluding who attempted to be randomized more than once into a bococizumab CV outcomes trial (B1481022/B1481038) or attempted to be randomized in more than 1 CV outcomes trial and all participants enrolled at study Site 3027 where a quality-related event was identified. | Posted | Number | 95% Confidence Interval | Events Per 100 Participant-Years | From baseline until the date of first adjudicated and confirmed occurrence of hospitalization for unstable angina needing urgent revascularization (maximum duration: up to 3.4 years) |
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| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Composite Endpoint of Cardiovascular Death, Non-Fatal Myocardial Infarction, Non-Fatal Stroke and Hospitalization for Unstable Angina | Event rate per 100 participant-years for first occurrence of composite endpoint of cardiovascular death, non-fatal MI, non-fatal stroke and hospitalization for unstable angina (adjudicated by adjudication committee) was reported. Cardiovascular death was defined as sudden cardiac death, fatal MI, death due to heart failure, death due to stroke (fatal ischemic stroke or fatal stroke of undetermined etiology), or death due to other cardiovascular causes. Event rate was calculated as the number of events per 100 participant-years at risk. | FAS: all participants who were randomized, excluding who attempted to be randomized more than once into a bococizumab CV outcomes trial (B1481022/B1481038) or attempted to be randomized in more than 1 CV outcomes trial and all participants enrolled at study Site 3027 where a quality-related event was identified. | Posted | Number | 95% Confidence Interval | Events Per 100 Participant-Years | From baseline until the date of first adjudicated and confirmed occurrence of cardiovascular death, non-fatal MI, non-fatal stroke and hospitalization for unstable angina (maximum duration: up to 3.4 years) |
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| Secondary | Event Rate Per 100 Participant-Years For Cardiovascular Death | Event rate per 100 participant-years for cardiovascular death (adjudicated by adjudication committee) was reported. Cardiovascular death was defined as sudden cardiac death, fatal MI, death due to heart failure, death due to stroke (fatal ischemic stroke or fatal stroke of undetermined etiology), or death due to other cardiovascular causes. Event rate was calculated as the number of events per 100 participant-years at risk. | FAS: all participants who were randomized, excluding who attempted to be randomized more than once into a bococizumab CV outcomes trial (B1481022/B1481038) or attempted to be randomized in more than 1 CV outcomes trial and all participants enrolled at study Site 3027 where a quality-related event was identified. | Posted | Number | 95% Confidence Interval | Events Per 100 Participant-Years | From baseline until the date of adjudicated and confirmed occurrence of cardiovascular death (maximum duration: up to 3.4 years) |
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| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Any Myocardial Infarction (Fatal or Non-Fatal) | Event rate per 100 participant-years for first occurrence of any MI (fatal or non-fatal) (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | FAS: all participants who were randomized, excluding who attempted to be randomized more than once into a bococizumab CV outcomes trial (B1481022/B1481038) or attempted to be randomized in more than 1 CV outcomes trial and all participants enrolled at study Site 3027 where a quality-related event was identified. | Posted | Number | 95% Confidence Interval | Events Per 100 Participant-Years | From baseline until the date of first adjudicated and confirmed occurrence of any MI (fatal or non-fatal) (maximum duration: up to 3.4 years) |
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| Secondary | Event Rate Per 100 Participant-Years For Fatal Myocardial Infarction | Event rate per 100 participant-years for fatal MI (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | FAS: all participants who were randomized, excluding who attempted to be randomized more than once into a bococizumab CV outcomes trial (B1481022/B1481038) or attempted to be randomized in more than 1 CV outcomes trial and all participants enrolled at study Site 3027 where a quality-related event was identified. | Posted | Number | 95% Confidence Interval | Events Per 100 Participant-Years | From baseline until the date of adjudicated and confirmed occurrence of fatal MI (maximum duration: up to 3.4 years) |
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| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Non-Fatal Myocardial Infarction | Event rate per 100 participant-years for first occurrence of non-fatal MI (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | FAS: all participants who were randomized, excluding who attempted to be randomized more than once into a bococizumab CV outcomes trial (B1481022/B1481038) or attempted to be randomized in more than 1 CV outcomes trial and all participants enrolled at study Site 3027 where a quality-related event was identified. | Posted | Number | 95% Confidence Interval | Events Per 100 Participant-Years | From baseline until the date of first adjudicated and confirmed occurrence of non-fatal MI (maximum duration: up to 3.4 years) |
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| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Any Stroke (Fatal or Non-Fatal) | Event rate per 100 participant-years for first occurrence of any stroke (fatal or non-fatal) (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | FAS: all participants who were randomized, excluding who attempted to be randomized more than once into a bococizumab CV outcomes trial (B1481022/B1481038) or attempted to be randomized in more than 1 CV outcomes trial and all participants enrolled at study Site 3027 where a quality-related event was identified. | Posted | Number | 95% Confidence Interval | Events Per 100 Participant-Years | From baseline until the date of first adjudicated and confirmed occurrence of any stroke (fatal or non-fatal) (maximum duration: up to 3.4 years) |
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| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Any Stroke (Fatal or Non-Fatal), of Any Etiology | Event rate per 100 participant-years for first occurrence of any stroke (fatal or non-fatal), of any etiology (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | FAS: all participants who were randomized, excluding who attempted to be randomized more than once into a bococizumab CV outcomes trial (B1481022/B1481038) or attempted to be randomized in more than 1 CV outcomes trial and all participants enrolled at study Site 3027 where a quality-related event was identified. | Posted | Number | 95% Confidence Interval | Events Per 100 Participant-Years | From baseline until the date of first adjudicated and confirmed occurrence of any stroke (fatal or non-fatal), of any etiology (maximum duration: up to 3.4 years) |
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| Secondary | Event Rate Per 100 Participant-Years For Fatal Stroke | Event rate per 100 participant-years for fatal stroke (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | FAS: all participants who were randomized, excluding who attempted to be randomized more than once into a bococizumab CV outcomes trial (B1481022/B1481038) or attempted to be randomized in more than 1 CV outcomes trial and all participants enrolled at study Site 3027 where a quality-related event was identified. | Posted | Number | 95% Confidence Interval | Events Per 100 Participant-Years | From baseline until the date of first adjudicated and confirmed occurrence of fatal stroke (maximum duration: up to 3.4 years) |
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| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Non-Fatal Stroke | Event rate per 100 participant-years for first occurrence of non-fatal stroke (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | FAS: all participants who were randomized, excluding who attempted to be randomized more than once into a bococizumab CV outcomes trial (B1481022/B1481038) or attempted to be randomized in more than 1 CV outcomes trial and all participants enrolled at study Site 3027 where a quality-related event was identified. | Posted | Number | 95% Confidence Interval | Events Per 100 Participant-Years | From baseline until the date of first adjudicated and confirmed occurrence of non-fatal stroke (maximum duration: up to 3.4 years) |
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| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Hospitalization for Unstable Angina | Event rate per 100 participant-years for first occurrence of hospitalization for unstable angina (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | FAS: all participants who were randomized, excluding who attempted to be randomized more than once into a bococizumab CV outcomes trial (B1481022/B1481038) or attempted to be randomized in more than 1 CV outcomes trial and all participants enrolled at study Site 3027 where a quality-related event was identified. | Posted | Number | 95% Confidence Interval | Events Per 100 Participant-Years | From baseline until the date of first adjudicated and confirmed occurrence of hospitalization for unstable angina (maximum duration: up to 3.4 years) |
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| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Hospitalization for Congestive Heart Failure (CHF) | Event rate per 100 participant-years for first occurrence of hospitalization for CHF (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | FAS: all participants who were randomized, excluding who attempted to be randomized more than once into a bococizumab CV outcomes trial (B1481022/B1481038) or attempted to be randomized in more than 1 CV outcomes trial and all participants enrolled at study Site 3027 where a quality-related event was identified. | Posted | Number | 95% Confidence Interval | Events Per 100 Participant-Years | From baseline until the date of first adjudicated and confirmed occurrence of hospitalization for congestive heart failure (maximum duration: up to 3.4 years) |
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| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Coronary Revascularization | Event rate per 100 participant-years for first occurrence of coronary revascularization (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | FAS: all participants who were randomized, excluding who attempted to be randomized more than once into a bococizumab CV outcomes trial (B1481022/B1481038) or attempted to be randomized in more than 1 CV outcomes trial and all participants enrolled at study Site 3027 where a quality-related event was identified. | Posted | Number | 95% Confidence Interval | Events Per 100 Participant-Years | From baseline until the date of first adjudicated and confirmed occurrence of coronary revascularization (maximum duration: up to 3.4 years) |
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| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Coronary Artery Bypass Graft Surgery (CABG) | Event rate per 100 participant-years for first occurrence of CABG (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | FAS: all participants who were randomized, excluding who attempted to be randomized more than once into a bococizumab CV outcomes trial (B1481022/B1481038) or attempted to be randomized in more than 1 CV outcomes trial and all participants enrolled at study Site 3027 where a quality-related event was identified. | Posted | Number | 95% Confidence Interval | Events Per 100 Participant-Years | From baseline until the date of first adjudicated and confirmed occurrence of CABG (maximum duration: up to 3.4 years) |
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| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Percutaneous Coronary Intervention (PCI) | Event rate per 100 participant-years for first occurrence of PCI (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | FAS: all participants who were randomized, excluding who attempted to be randomized more than once into a bococizumab CV outcomes trial (B1481022/B1481038) or attempted to be randomized in more than 1 CV outcomes trial and all participants enrolled at study Site 3027 where a quality-related event was identified. | Posted | Number | 95% Confidence Interval | Events Per 100 Participant-Years | From baseline until the date of first adjudicated and confirmed occurrence of PCI (maximum duration: up to 3.4 years) |
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| Secondary | Event Rate Per 100 Participant-Years For First Occurrence of Any Arterial Revascularizations | Event rate per 100 participant-years for first occurrence of any arterial revascularizations (adjudicated by adjudication committee) was reported. Event rate was calculated as the number of events per 100 participant-years at risk. | FAS: all participants who were randomized, excluding who attempted to be randomized more than once into a bococizumab CV outcomes trial (B1481022/B1481038) or attempted to be randomized in more than 1 CV outcomes trial and all participants enrolled at study Site 3027 where a quality-related event was identified. | Posted | Number | 95% Confidence Interval | Events Per 100 Participant-Years | From baseline until the date of first adjudicated and confirmed occurrence of any arterial revascularizations (maximum duration: up to 3.4 years) |
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| Secondary | Event Rate Per 100 Participant-Years For All-Cause Death | Event rate per 100 participant-years for all-cause death (adjudicated by adjudication committee) was reported. All-cause death was defined as the death due to any cause during the course of study. Event rate was calculated as the number of events per 100 participant-years at risk. | FAS: all participants who were randomized, excluding who attempted to be randomized more than once into a bococizumab CV outcomes trial (B1481022/B1481038) or attempted to be randomized in more than 1 CV outcomes trial and all participants enrolled at study Site 3027 where a quality-related event was identified. | Posted | Number | 95% Confidence Interval | Events Per 100 Participant-Years | From baseline until the date of adjudicated and confirmed occurrence of all-cause death (maximum duration: up to 3.4 years) |
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| Secondary | Percent Change From Baseline in Low Density Lipoprotein Cholesterol at Week 14 | Analysis was performed on FAS. Here, "Number of participants analyzed "(N) signifies those participants who were evaluable for this outcome measure. | Posted | Least Squares Mean | Standard Error | Percent change | Baseline, Week 14 |
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| Secondary | Nominal Change From Baseline in Low Density Lipoprotein Cholesterol at Week 14 | Analysis was performed on FAS. Here, "N" signifies number of participants who were evaluable for this outcome measure. | Posted | Least Squares Mean | Standard Error | mg/dL | Baseline, Week 14 |
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| Secondary | Percent Change From Baseline in Low Density Lipoprotein Cholesterol at Last Post-Baseline Measurement | Analysis was performed on FAS. Here, "N" signifies number of participants who were evaluable for this outcome measure. | Posted | Least Squares Mean | Standard Error | Percent Change | Baseline, last post-baseline measurement (any time up to Week 140) |
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| Secondary | Percent Change From Baseline in Lipid Levels at Week 14 | Lipids included non-high density lipoprotein cholesterol (non-HDL-C), total cholesterol, very low density lipoprotein cholesterol (VLDL-C), remnant lipoprotein cholesterol (RLP-C), apolipoprotein B (Apo B), HDL-C and apolipoprotein A-I (Apo A-I). | Analysis was performed on FAS. Here, number analyzed "n" signifies number of participants who were evaluable for the specified categories. | Posted | Least Squares Mean | Standard Error | Percent Change | Baseline, Week 14 |
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| Secondary | Percent Change From Baseline in Log-Transformed Lipoprotein (a) (Lp[a]) and Triglycerides at Week 14 | Analysis was performed on FAS. Here, number analyzed "n" signifies number of participants who were evaluable for the specified categories. | Posted | Mean | Standard Deviation | Percent Change | Baseline, Week 14 |
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| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Secondary | Percent Change From Baseline in Log-Transformed High Sensitivity C-Reactive Protein (Hs-CRP) at Week 14 | Analysis was performed on FAS. Here, "N" signifies number of participants who were evaluable for this outcome measure. | Posted | Mean | Standard Deviation | Percent change | Baseline, Week 14 |
|
|
Baseline up to 3.4 years
Safety analysis set: all participants who randomized, had atleast 1 dose of study drug, excluding those attempted to randomize more than once in a bococizumab CV outcomes trial (B1481022/B1481038) or attempted to randomize in more than 1 CV outcomes trial, and all participants enrolled at study Site 3027 where a quality-related event was identified
Not provided
| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Placebo | Participants received single dose of placebo matched to PF-04950615 subcutaneous injection once every 2 weeks for upto 3 years. Participants were followed up to 40 days after the last dose. | 65 | 8,374 | 986 | 8,374 | 1,570 | 8,374 |
| EG001 | Bococizumab (PF-04950615) | Participants received single dose of PF-04950615 150 milligrams, subcutaneous injection once every 2 weeks for upto 3 years. Participants were followed up to 40 days after the last dose. | 72 | 8,386 | 1,060 | 8,386 | 2,015 | 8,386 |
| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| Anaemia | Blood and lymphatic system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Haemorrhagic anaemia | Blood and lymphatic system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Iron deficiency anaemia | Blood and lymphatic system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Leukocytosis | Blood and lymphatic system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Lymphadenopathy | Blood and lymphatic system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pancytopenia | Blood and lymphatic system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Acute coronary syndrome | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Acute left ventricular failure | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Acute myocardial infarction | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Angina pectoris | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Angina unstable | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Aortic valve stenosis | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Arrhythmia | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Arteriosclerosis coronary artery | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Atrial fibrillation | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Atrial flutter | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Atrial tachycardia | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Atrial thrombosis | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Atrioventricular block complete | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Atrioventricular block second degree | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Bradycardia | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cardiac arrest | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cardiac discomfort | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cardiac disorder | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cardiac failure | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cardiac failure acute | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cardiac failure chronic | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cardiac failure congestive | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cardio-respiratory arrest | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cardiogenic shock | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Coronary artery disease | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Coronary artery dissection | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Coronary artery insufficiency | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Coronary artery occlusion | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Coronary artery stenosis | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Heart valve incompetence | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Ischaemic cardiomyopathy | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Left ventricular failure | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Microvascular coronary artery disease | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Myocardial infarction | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Myocardial ischaemia | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Palpitations | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pericardial effusion | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pericarditis | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Sinus bradycardia | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Sinus node dysfunction | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Sinus tachycardia | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Stress cardiomyopathy | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Supraventricular tachycardia | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Tachyarrhythmia | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Tachycardia | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Ventricular arrhythmia | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Ventricular dysfunction | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Ventricular fibrillation | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Ventricular tachycardia | Cardiac disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hereditary haemorrhagic telangiectasia | Congenital, familial and genetic disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Deafness unilateral | Ear and labyrinth disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Eustachian tube dysfunction | Ear and labyrinth disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Vertigo | Ear and labyrinth disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Vestibular disorder | Ear and labyrinth disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hyperparathyroidism | Endocrine disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hypothyroidism | Endocrine disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Thyroid mass | Endocrine disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Angle closure glaucoma | Eye disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cataract | Eye disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Diabetic retinopathy | Eye disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Lens dislocation | Eye disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Macular fibrosis | Eye disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Optic ischaemic neuropathy | Eye disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Retinal artery occlusion | Eye disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Retinal detachment | Eye disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Retinal exudates | Eye disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Visual impairment | Eye disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Vitreous haemorrhage | Eye disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Abdominal discomfort | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Abdominal distension | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Abdominal hernia | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Abdominal hernia obstructive | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Abdominal pain | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Abdominal pain lower | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Abdominal pain upper | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Abdominal wall haematoma | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Anal polyp | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Anal prolapse | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Appendix disorder | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Ascites | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Chronic gastritis | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Colitis | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Colitis ischaemic | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Colonic pseudo-obstruction | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Constipation | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Dental caries | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Diarrhoea | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Diverticulum intestinal | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Diverticulum intestinal haemorrhagic | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Duodenitis | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Dyspepsia | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Enteritis | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Food poisoning | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gastric haemorrhage | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gastric perforation | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gastric polyps | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gastric ulcer | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gastric ulcer haemorrhage | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gastritis | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gastritis erosive | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gastroduodenitis | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gastrointestinal haemorrhage | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gastrointestinal necrosis | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gastrointestinal polyp haemorrhage | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gastrooesophageal reflux disease | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gingival bleeding | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Haematemesis | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Haemorrhoidal haemorrhage | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Haemorrhoids | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hiatus hernia | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Ileus | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Impaired gastric emptying | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Incarcerated umbilical hernia | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Inguinal hernia | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Intestinal haemorrhage | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Intestinal ischaemia | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Intestinal obstruction | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Intestinal strangulation | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Large intestine polyp | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Lower gastrointestinal haemorrhage | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Mechanical ileus | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Melaena | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Necrotising colitis | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Obstruction gastric | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Oesophageal spasm | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Oesophageal stenosis | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Oesophagitis | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pancreatitis | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pancreatitis acute | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Peptic ulcer perforation | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Rectal haemorrhage | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Rectal polyp | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Salivary gland enlargement | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Short-bowel syndrome | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Small intestinal obstruction | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Small intestinal stenosis | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Thrombosis mesenteric vessel | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Tongue oedema | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Ulcerative gastritis | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Umbilical hernia | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Upper gastrointestinal haemorrhage | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Vomiting | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Asthenia | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cardiac death | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Chest pain | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Death | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Electrocution | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Fatigue | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| General physical health deterioration | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Generalised oedema | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hyperplasia | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Ill-defined disorder | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Impaired healing | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Inflammation | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Injection site hypersensitivity | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Injection site reaction | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Mucosal inflammation | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Multiple organ dysfunction syndrome | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Necrosis | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Non-cardiac chest pain | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Oedema peripheral | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pain | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pelvic mass | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pyrexia | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Sudden cardiac death | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Sudden death | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Systemic inflammatory response syndrome | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Vascular stent restenosis | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Vascular stent thrombosis | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Bile duct stenosis | Hepatobiliary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Bile duct stone | Hepatobiliary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Biliary colic | Hepatobiliary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Biliary dyskinesia | Hepatobiliary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cholangitis | Hepatobiliary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cholecystitis | Hepatobiliary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cholecystitis acute | Hepatobiliary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cholecystitis chronic | Hepatobiliary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cholecystocholangitis | Hepatobiliary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cholelithiasis | Hepatobiliary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Drug-induced liver injury | Hepatobiliary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hepatic cirrhosis | Hepatobiliary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hepatic failure | Hepatobiliary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hepatitis | Hepatobiliary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Non-alcoholic fatty liver | Hepatobiliary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Anaphylactic shock | Immune system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hypersensitivity | Immune system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Abdominal abscess | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Abdominal wall abscess | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Abscess limb | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Abscess neck | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Acute sinusitis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Anal abscess | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Appendicitis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Arthritis bacterial | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Arthritis infective | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Bacterial sepsis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Bronchitis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Bursitis infective | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Bursitis infective staphylococcal | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Carbuncle | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cellulitis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cellulitis of male external genital organ | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment | This is gender specific event. |
|
| Clostridium colitis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Clostridium difficile colitis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Clostridium difficile infection | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Creutzfeldt-Jakob disease | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cystitis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Dermo-hypodermitis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Diabetic foot infection | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Diverticulitis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Emphysematous pyelonephritis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Endocarditis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Endocarditis bacterial | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Endocarditis enterococcal | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Endometritis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Epididymitis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Erysipelas | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Furuncle | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gangrene | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gastritis viral | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gastroenteritis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gastroenteritis bacterial | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gastroenteritis salmonella | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gastroenteritis viral | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Groin abscess | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| H1N1 influenza | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Haematoma infection | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hepatitis E | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Herpes zoster | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Incision site infection | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Infected bite | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Infected fistula | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Infected seroma | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Infected skin ulcer | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Infectious pleural effusion | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Infective exacerbation of chronic obstructive airways disease | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Influenza | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Kidney infection | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Klebsiella sepsis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Localised infection | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Lower respiratory tract infection | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Lower respiratory tract infection viral | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Lung infection | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Lyme disease | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Nasopharyngitis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Orchitis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Osteomyelitis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Osteomyelitis bacterial | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Osteomyelitis chronic | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Otitis media | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Paronychia | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Penile infection | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Periodontitis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Perirectal abscess | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Peritonitis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pneumonia | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pneumonia bacterial | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pneumonia viral | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Post procedural cellulitis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Post procedural infection | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Post procedural pneumonia | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Prostatic abscess | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment | This is gender specific event. |
|
| Pyelonephritis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pyelonephritis acute | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pyomyositis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Rectal abscess | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Respiratory tract infection | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Sepsis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Sepsis syndrome | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Septic shock | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Skin candida | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Skin infection | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Staphylococcal bacteraemia | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Staphylococcal infection | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Streptococcal infection | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Subcutaneous abscess | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Superinfection | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Tonsillitis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Tracheitis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Tracheobronchitis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Tuberculosis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Upper respiratory tract infection | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Urinary tract infection | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Urosepsis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Vestibular neuronitis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Viral infection | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Viral sepsis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Viral upper respiratory tract infection | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Visceral leishmaniasis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Wound infection | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Wound infection staphylococcal | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Acetabulum fracture | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Anaemia postoperative | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Animal bite | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Ankle fracture | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Arterial injury | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Brain herniation | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Burns second degree | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cardiac function disturbance postoperative | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cerebral ventricle collapse | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Chest injury | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Clavicle fracture | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Concussion | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Contusion | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Coronary vascular graft occlusion | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Craniocerebral injury | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Eye injury | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Fall | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Femoral neck fracture | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Femur fracture | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Foot fracture | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gastrointestinal anastomotic leak | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gun shot wound | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Head injury | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Heat exhaustion | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hip fracture | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Humerus fracture | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Incisional hernia | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Intentional overdose | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Joint dislocation | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Laceration | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Ligament rupture | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Limb injury | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Lower limb fracture | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Mallet finger | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Meniscus injury | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Multiple fractures | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Multiple injuries | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Muscle rupture | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Muscle strain | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Overdose | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Patella fracture | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pelvic fracture | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Peripheral artery restenosis | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Post concussion syndrome | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Post procedural complication | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Post procedural haematoma | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Post procedural haemorrhage | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Post procedural oedema | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Postoperative delirium | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Postoperative thoracic procedure complication | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Procedural complication | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Procedural haemorrhage | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Procedural hypertension | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Procedural pain | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pubis fracture | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Radius fracture | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Rib fracture | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Road traffic accident | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Seroma | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Skin abrasion | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Skull fracture | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Soft tissue injury | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Spinal column injury | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Spinal compression fracture | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Spinal fracture | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Subarachnoid haemorrhage | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Subdural haematoma | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Tendon injury | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Tendon rupture | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Thermal burn | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Thoracic vertebral fracture | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Tibia fracture | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Toxicity to various agents | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Traumatic intracranial haemorrhage | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Ulna fracture | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Upper limb fracture | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Vascular bypass dysfunction | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Vascular graft occlusion | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Vascular pseudoaneurysm | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Vena cava injury | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Wound | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Wound dehiscence | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Wrist fracture | Injury, poisoning and procedural complications | MedDRA 19.1 | Non-systematic Assessment |
| |
| Alanine aminotransferase increased | Investigations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Aspartate aminotransferase increased | Investigations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Blood creatine phosphokinase increased | Investigations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Blood glucose decreased | Investigations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Blood glucose increased | Investigations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Blood pressure decreased | Investigations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Blood pressure diastolic decreased | Investigations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cardiac stress test abnormal | Investigations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Electrocardiogram abnormal | Investigations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gamma-glutamyltransferase increased | Investigations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Heart rate abnormal | Investigations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hepatic enzyme increased | Investigations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hepatitis C virus test positive | Investigations | MedDRA 19.1 | Non-systematic Assessment |
| |
| International normalised ratio abnormal | Investigations | MedDRA 19.1 | Non-systematic Assessment |
| |
| International normalised ratio decreased | Investigations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Liver function test abnormal | Investigations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Liver function test increased | Investigations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Stress echocardiogram abnormal | Investigations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Weight decreased | Investigations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Dehydration | Metabolism and nutrition disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Diabetes mellitus | Metabolism and nutrition disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Diabetes mellitus inadequate control | Metabolism and nutrition disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Diabetes with hyperosmolarity | Metabolism and nutrition disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Diabetic ketoacidosis | Metabolism and nutrition disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Fluid overload | Metabolism and nutrition disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gout | Metabolism and nutrition disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hyperglycaemia | Metabolism and nutrition disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hyperkalaemia | Metabolism and nutrition disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hyperosmolar hyperglycaemic state | Metabolism and nutrition disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hypervolaemia | Metabolism and nutrition disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hypoglycaemia | Metabolism and nutrition disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hypokalaemia | Metabolism and nutrition disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hypomagnesaemia | Metabolism and nutrition disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hyponatraemia | Metabolism and nutrition disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hypovolaemia | Metabolism and nutrition disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Insulin-requiring type 2 diabetes mellitus | Metabolism and nutrition disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Ketoacidosis | Metabolism and nutrition disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Lactic acidosis | Metabolism and nutrition disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Metabolic acidosis | Metabolism and nutrition disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Obesity | Metabolism and nutrition disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Type 2 diabetes mellitus | Metabolism and nutrition disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Vitamin B12 deficiency | Metabolism and nutrition disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Arthralgia | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Arthritis | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Arthropathy | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Back pain | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Bone lesion | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Bursitis | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cervical spinal stenosis | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Costochondritis | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Diabetic arthropathy | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gouty arthritis | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Intervertebral disc degeneration | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Intervertebral disc disorder | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Intervertebral disc protrusion | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Knee deformity | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Lumbar spinal stenosis | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Muscle tightness | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Muscular weakness | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Musculoskeletal chest pain | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Musculoskeletal pain | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Myalgia | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Neck pain | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Osteoarthritis | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Osteolysis | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Osteonecrosis | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Osteoporotic fracture | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pain in extremity | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Rhabdomyolysis | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Rheumatoid arthritis | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Rotator cuff syndrome | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Spinal column stenosis | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Spinal osteoarthritis | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Spinal pain | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Spondylitis | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Spondylolisthesis | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Synovial cyst | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Tendonitis | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Trigger finger | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Adenocarcinoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Adenocarcinoma gastric | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Adenocarcinoma of colon | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Anal squamous cell carcinoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| B-cell lymphoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Benign gastrointestinal neoplasm | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Bile duct cancer | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Bladder cancer | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Bladder cancer recurrent | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Bladder neoplasm | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Bladder papilloma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Bladder transitional cell carcinoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Bladder transitional cell carcinoma stage I | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Bone cancer | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Breast cancer | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Breast cancer recurrent | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cholesteatoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Chronic myelomonocytic leukaemia | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Clear cell renal cell carcinoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Colon cancer | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Colon cancer metastatic | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Colon cancer stage III | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Colorectal cancer | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gastric adenoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gastric cancer | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gastrointestinal stromal tumour | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gastrointestinal tract adenoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Gastrooesophageal cancer | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Glioblastoma multiforme | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Intestinal adenocarcinoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Intraocular melanoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Large cell lung cancer | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Laryngeal cancer | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Lip and/or oral cavity cancer stage 0 | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Lipoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Liposarcoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Lung adenocarcinoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Lung adenocarcinoma metastatic | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Lung cancer metastatic | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Lung neoplasm | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Lung neoplasm malignant | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Lung squamous cell carcinoma stage III | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Lymphoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Malignant melanoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Maxillofacial sinus neoplasm | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Meningioma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Mesothelioma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Metastases to bone | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Metastases to liver | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Metastases to lymph nodes | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Metastases to peritoneum | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Metastases to spine | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Metastatic malignant melanoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Metastatic neoplasm | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Metastatic squamous cell carcinoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Nasal neoplasm | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Neuroendocrine carcinoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Non-small cell lung cancer | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Oesophageal adenocarcinoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Ovarian adenoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment | This is gender specific event. |
|
| Pancreatic carcinoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pancreatic neoplasm | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Plasma cell myeloma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Prostate cancer | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment | This is gender specific event. |
|
| Prostate cancer metastatic | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment | This is gender specific event. |
|
| Prostatic adenoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment | This is gender specific event. |
|
| Rectal adenoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Rectal cancer | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Renal cancer | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Renal cancer recurrent | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Renal cell carcinoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Small cell lung cancer | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Soft tissue neoplasm | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Squamous cell carcinoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Squamous cell carcinoma of lung | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Squamous cell carcinoma of the cervix | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment | This is gender specific event. |
|
| Tonsil cancer | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Transitional cell carcinoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment |
| |
| Uterine leiomyoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | MedDRA 19.1 | Non-systematic Assessment | This is gender specific event. |
|
| Axonal neuropathy | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Balance disorder | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Basal ganglia haemorrhage | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Brain stem infarction | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Carotid arteriosclerosis | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Carotid artery disease | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Carotid artery occlusion | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Carotid artery stenosis | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Carpal tunnel syndrome | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cauda equina syndrome | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cerebellar haemorrhage | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cerebellar infarction | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cerebral artery occlusion | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cerebral haematoma | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cerebral haemorrhage | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cerebral infarction | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cerebral venous thrombosis | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cerebrovascular accident | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cervical radiculopathy | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Chorea | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Coma | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cubital tunnel syndrome | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Diabetic neuropathy | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Dizziness | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Embolic stroke | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Encephalopathy | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Epilepsy | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Facial paresis | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Haemorrhage intracranial | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Haemorrhagic cerebral infarction | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Haemorrhagic stroke | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Headache | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hemiparesis | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hypoaesthesia | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hypoglycaemic coma | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Intraventricular haemorrhage | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Ischaemic stroke | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Lacunar infarction | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Lacunar stroke | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Loss of consciousness | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Lumbar radiculopathy | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Lumbosacral radiculopathy | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Migraine | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Nerve compression | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Nervous system disorder | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Paraesthesia | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Partial seizures | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Polyneuropathy | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Post stroke epilepsy | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Presyncope | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Radiculopathy | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Sciatica | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Seizure | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Syncope | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Thalamus haemorrhage | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Transient global amnesia | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Transient ischaemic attack | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Vascular dementia | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Vertigo CNS origin | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Abortion spontaneous | Pregnancy, puerperium and perinatal conditions | MedDRA 19.1 | Non-systematic Assessment | This is gender specific event. |
|
| Device battery issue | Product Issues | MedDRA 19.1 | Non-systematic Assessment |
| |
| Device dislocation | Product Issues | MedDRA 19.1 | Non-systematic Assessment |
| |
| Acute psychosis | Psychiatric disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Alcohol withdrawal syndrome | Psychiatric disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Alcoholism | Psychiatric disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Anxiety | Psychiatric disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Confusional state | Psychiatric disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Conversion disorder | Psychiatric disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Delirium | Psychiatric disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Depression | Psychiatric disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Depression suicidal | Psychiatric disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Factitious disorder | Psychiatric disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Major depression | Psychiatric disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Mental status changes | Psychiatric disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Personality disorder | Psychiatric disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Suicidal ideation | Psychiatric disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Suicide attempt | Psychiatric disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Acute kidney injury | Renal and urinary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Acute prerenal failure | Renal and urinary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Calculus urethral | Renal and urinary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Chronic kidney disease | Renal and urinary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cystitis noninfective | Renal and urinary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Haematuria | Renal and urinary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hydronephrosis | Renal and urinary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Ischaemic nephropathy | Renal and urinary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Nephritis | Renal and urinary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Nephrolithiasis | Renal and urinary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Nephropathy | Renal and urinary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Renal artery stenosis | Renal and urinary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Renal cortical necrosis | Renal and urinary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Renal disorder | Renal and urinary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Renal failure | Renal and urinary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Renal impairment | Renal and urinary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Renal ischaemia | Renal and urinary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Stag horn calculus | Renal and urinary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Stress urinary incontinence | Renal and urinary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Ureterolithiasis | Renal and urinary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Urethral obstruction | Renal and urinary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Urinary bladder haemorrhage | Renal and urinary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Urinary incontinence | Renal and urinary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Urinary retention | Renal and urinary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Urinary tract obstruction | Renal and urinary disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Benign prostatic hyperplasia | Reproductive system and breast disorders | MedDRA 19.1 | Non-systematic Assessment | This is gender specific event. |
|
| Cystocele | Reproductive system and breast disorders | MedDRA 19.1 | Non-systematic Assessment | This is gender specific event. |
|
| Fallopian tube obstruction | Reproductive system and breast disorders | MedDRA 19.1 | Non-systematic Assessment | This is gender specific event. |
|
| Genital prolapse | Reproductive system and breast disorders | MedDRA 19.1 | Non-systematic Assessment | This is gender specific event. |
|
| Menorrhagia | Reproductive system and breast disorders | MedDRA 19.1 | Non-systematic Assessment | This is gender specific event. |
|
| Ovarian cyst | Reproductive system and breast disorders | MedDRA 19.1 | Non-systematic Assessment | This is gender specific event. |
|
| Prostatic dysplasia | Reproductive system and breast disorders | MedDRA 19.1 | Non-systematic Assessment | This is gender specific event. |
|
| Prostatic obstruction | Reproductive system and breast disorders | MedDRA 19.1 | Non-systematic Assessment | This is gender specific event. |
|
| Prostatitis | Reproductive system and breast disorders | MedDRA 19.1 | Non-systematic Assessment | This is gender specific event. |
|
| Prostatomegaly | Reproductive system and breast disorders | MedDRA 19.1 | Non-systematic Assessment | This is gender specific event. |
|
| Rectocele | Reproductive system and breast disorders | MedDRA 19.1 | Non-systematic Assessment | This is gender specific event. |
|
| Uterine polyp | Reproductive system and breast disorders | MedDRA 19.1 | Non-systematic Assessment | This is gender specific event. |
|
| Uterine prolapse | Reproductive system and breast disorders | MedDRA 19.1 | Non-systematic Assessment | This is gender specific event. |
|
| Vaginal haemorrhage | Reproductive system and breast disorders | MedDRA 19.1 | Non-systematic Assessment | This is gender specific event. |
|
| Vaginal prolapse | Reproductive system and breast disorders | MedDRA 19.1 | Non-systematic Assessment | This is gender specific event. |
|
| Vaginal ulceration | Reproductive system and breast disorders | MedDRA 19.1 | Non-systematic Assessment | This is gender specific event. |
|
| Acute pulmonary oedema | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Acute respiratory failure | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Asthma | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Atelectasis | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Bronchial disorder | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Bronchial hyperreactivity | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Bronchiectasis | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Bronchospasm | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Chronic obstructive pulmonary disease | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Chronic respiratory failure | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Dyspnoea | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Dyspnoea exertional | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Emphysema | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Epistaxis | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Haemoptysis | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hypoxia | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Interstitial lung disease | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Lung disorder | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Nasal disorder | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Nasal turbinate hypertrophy | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Oropharyngeal swelling | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pleural effusion | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pleurisy | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pleuritic pain | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pneumomediastinum | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pneumonia aspiration | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pneumonitis | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pneumothorax | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pulmonary artery thrombosis | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pulmonary embolism | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pulmonary hypertension | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pulmonary mass | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pulmonary oedema | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Respiratory distress | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Respiratory failure | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Sinus disorder | Respiratory, thoracic and mediastinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Angioedema | Skin and subcutaneous tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Cutaneous vasculitis | Skin and subcutaneous tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Decubitus ulcer | Skin and subcutaneous tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Dermatitis allergic | Skin and subcutaneous tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Diabetic foot | Skin and subcutaneous tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Petechiae | Skin and subcutaneous tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Psoriasis | Skin and subcutaneous tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Rash generalised | Skin and subcutaneous tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Skin lesion | Skin and subcutaneous tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Skin necrosis | Skin and subcutaneous tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Skin reaction | Skin and subcutaneous tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Skin ulcer | Skin and subcutaneous tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Pregnancy of partner | Social circumstances | MedDRA 19.1 | Non-systematic Assessment | This is gender specific event. |
|
| Hospitalisation | Surgical and medical procedures | MedDRA 19.1 | Non-systematic Assessment |
| |
| Accelerated hypertension | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Aneurysm | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Aortic aneurysm | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Aortic stenosis | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Arterial stenosis | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Arteriosclerosis | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Arteriovenous fistula | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Arteritis | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Brachiocephalic vein stenosis | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Circulatory collapse | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Deep vein thrombosis | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Dry gangrene | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Embolism arterial | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Extremity necrosis | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Femoral artery aneurysm | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Granulomatosis with polyangiitis | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Haematoma | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hypertension | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hypertensive crisis | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hypertensive emergency | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hypotension | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hypovolaemic shock | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Iliac artery occlusion | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Infarction | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Intermittent claudication | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Ischaemia | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Lymphoedema | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Orthostatic hypotension | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Peripheral arterial occlusive disease | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Peripheral artery aneurysm | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Peripheral artery dissection | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Peripheral artery occlusion | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Peripheral artery stenosis | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Peripheral ischaemia | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Peripheral vascular disorder | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Peripheral venous disease | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Post thrombotic syndrome | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Shock haemorrhagic | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Subclavian artery occlusion | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Subclavian artery stenosis | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Varicose vein | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Vasculitis | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Venous thrombosis limb | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
|
| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| Diarrhoea | Gastrointestinal disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Injection site reaction | General disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Nasopharyngitis | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Upper respiratory tract infection | Infections and infestations | MedDRA 19.1 | Non-systematic Assessment |
| |
| Type 2 diabetes mellitus | Metabolism and nutrition disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Arthralgia | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Back pain | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Myalgia | Musculoskeletal and connective tissue disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Headache | Nervous system disorders | MedDRA 19.1 | Non-systematic Assessment |
| |
| Hypertension | Vascular disorders | MedDRA 19.1 | Non-systematic Assessment |
|
As specified in statistical analysis plan, due to discontinuation of the bococizumab clinical development program, health care resource utilization endpoints were not evaluated.
Pfizer has the right to review disclosures, requesting a delay of less than 60 days. Investigator will postpone single center publications until after disclosure of pooled data (all sites), less than 12 months from study completion/termination at all participating sites. Investigator may not disclose previously undisclosed confidential information other than study results.
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Pfizer ClinicalTrials.gov Call Center | Pfizer, Inc. | 1-800-718-1021 | ClinicalTrials.gov_Inquiries@pfizer.com |
| Prot_000.pdf |
| SAP | No | Yes | No | Statistical Analysis Plan | Dec 20, 2016 | Mar 14, 2018 | SAP_001.pdf |
| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D009203 | Myocardial Infarction |
| D020521 | Stroke |
| D006949 | Hyperlipidemias |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D014652 | Vascular Diseases |
| D007238 | Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D050171 | Dyslipidemias |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| C000598888 | bococizumab |
Not provided
Not provided
Not provided
| Male |
|
| Not Hispanic or Latino |
|
| Unknown or Not Reported |
|
| Asian |
|
| Native Hawaiian or Other Pacific Islander |
|
| Black or African American |
|
| White |
|
| More than one race |
|
| Unknown or Not Reported |
|
Participants received single dose of PF-04950615 150 milligrams, subcutaneous injection once every 2 weeks for upto 3 years. Participants were followed up to 40 days after the last dose.
|
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|
Participants received single dose of PF-04950615 150 milligrams, subcutaneous injection once every 2 weeks for upto 3 years. Participants were followed up to 40 days after the last dose. |
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| Bococizumab (PF-04950615) |
Participants received single dose of PF-04950615 150 milligrams, subcutaneous injection once every 2 weeks for upto 3 years. Participants were followed up to 40 days after the last dose. |
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