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| ID | Type | Description | Link |
|---|---|---|---|
| 82267 | Other Grant/Funding Number | American Pain Society |
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The broad aim of the study is to implement and evaluate the efficacy of Graded Exposure Treatment (GET Living) to target elevated pain-related fears in children with chronic pain. Pain-related fear is an important psychological factor associated with poor outcomes in children suffering with chronic pain. To examine the efficacy of GET Living in addressing pain-related fears the investigators propose to use a sequential replicated randomized single-case experimental phase design with multiple measures. The specific aims are to 1) evaluate the effectiveness and acceptability of individually tailored GET Living for children with high pain-related fear and functional disability and 2) define anatomical and resting state connectivity patterns in the brains of children and adolescents with complex chronic pain prior to and after participation in GET Living.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| GET Living Treatment | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| GET Living | Behavioral | GET Living is an exposure based treatment jointly delivered by a cognitive-behavioral therapist and physical therapy to help children and adolescents suffering with chronic pain and headache progressively return to valued life activities. |
| Measure | Description | Time Frame |
|---|---|---|
| Decrease in Fear of Pain | Decrease in Fear of Pain from Baseline to end of treatment at 6-weeks, on average |
| Measure | Description | Time Frame |
|---|---|---|
| Decrease in Functional Disability | Decrease in Functional Disability from Baseline to end of treatment at 6-weeks, on average | |
| Improvement in School Functioning | Improvement in School Functioning from baseline to end of treatment at 6-weeks, on average |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Laura E Simons, PhD | Boston Children's Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Boston Children's Hospital Waltham | Waltham | Massachusetts | 02453 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37624900 | Derived | Simons LE, Harrison LE, Boothroyd DB, Parvathinathan G, Van Orden AR, O'Brien SF, Schofield D, Kraindler J, Shrestha R, Vlaeyen JWS, Wicksell RK. A randomized controlled trial of graded exposure treatment (GET living) for adolescents with chronic pain. Pain. 2024 Jan 1;165(1):177-191. doi: 10.1097/j.pain.0000000000003010. Epub 2023 Aug 25. | |
| 36892929 |
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| ID | Term |
|---|---|
| D059350 | Chronic Pain |
| D009437 | Neuralgia |
| D059352 | Musculoskeletal Pain |
| D006261 | Headache |
| ID | Term |
|---|---|
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Decrease in Pain Catastrophizing | Decrease in Pain Catastrophizing from baseline to end of treatment at 6-weeks, on average |
| Decrease in Pain Intensity | Decrease in Pain Intensity from baseline to end of treatment at 6-weeks, on average |
| Increase in Physical Activity | Increase in Physical Activity from baseline to end of treatment at 6-weeks, on average |
| Schemer L, Hess CW, Van Orden AR, Birnie KA, Harrison LE, Glombiewski JA, Simons LE. Enhancing Exposure Treatment for Youths With Chronic Pain: Co-design and Qualitative Approach. J Particip Med. 2023 Mar 9;15:e41292. doi: 10.2196/41292. |
| 33482005 | Derived | Beebe JA, Kronman C, Mahmud F, Basch M, Hogan M, Li E, Ploski C, Simons LE. Gait Variability and Relationships With Fear, Avoidance, and Pain in Adolescents With Chronic Pain. Phys Ther. 2021 Apr 4;101(4):pzab012. doi: 10.1093/ptj/pzab012. |
| D010523 | Peripheral Nervous System Diseases |
| D009468 | Neuromuscular Diseases |
| D009422 | Nervous System Diseases |
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |