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in this study , effectiveness of supragingival irrigators containing chlorhexidine is compared with routine oral health measures in patients with blood dyscrasia whom can not use effective oral health measures(e.g brushing ) due to their systemic condition(e,g,neutropenia ,thrombocytopenia,..)
Since some patients with hematologic malignancies cannot brush effectively and are at increased risk of bleeding and infection due to severe neutropenia and thrombocytopenia we want to access whether a none invasive method ( water jet systems containing chlorhexidine ) Can help this patients to get better oral health indexes in comparison with routine oral health measures in these type of patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| water jet irrigator | Active Comparator | patients used supra-gingival irrigators as an oral health measure |
|
| control group | No Intervention | patients in this group received routine oral health care protocols. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| supragingival irrigators containing chlorhexidine | Device | patients received irrigation by oxyjet supra gingival irrigators containing chlorhexidine for at least 3 minutes for all dentulous regions of jaws which was performed by researchers once daily. |
| Measure | Description | Time Frame |
|---|---|---|
| improvement in oral health status | improvement of oral health was measured by oral health index simplified(OHI-S) | 3 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| incidence of oral mucositis | incidence of mucositis due to Who criteria explored by clinical examination | 3 weeks |
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Inclusion Criteria:
patients with a blood dyscrasia, severe neutropenia and thrombocytopenia, absence of periodontitis, absence of any oral mucosal lesion in onset of study, patient consent
Exclusion Criteria:
diabetes mellitus, observation of any side effect (resulted from the device), severe oral mucositis in intervention group(grade 3 and4 WHO), edentulousness, intolerance of device in severely malaise patients, patient death
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| Name | Affiliation | Role |
|---|---|---|
| Pegah Mosannen Mozafari, assistant professor | Oral and maxilloifacial diseases research center of Mashhad university of medical sciences | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Oral Medicine Department of Mashhad dental School,Oral and Maxillofacial diseases research center | Mashhad | Razavi Khorasan Province | Iran |
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| ID | Term |
|---|---|
| D009503 | Neutropenia |
| D013921 | Thrombocytopenia |
| D007938 | Leukemia |
| D006402 | Hematologic Diseases |
| ID | Term |
|---|---|
| D000380 | Agranulocytosis |
| D007970 | Leukopenia |
| D000095542 | Cytopenia |
| D006425 | Hemic and Lymphatic Diseases |
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|
| D007960 |
| Leukocyte Disorders |
| D001791 | Blood Platelet Disorders |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |