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| Name | Class |
|---|---|
| Gyeongsang National University Hospital | OTHER |
| Dong-A University Hospital | OTHER |
| Samsung Medical Center | OTHER |
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The aims of this study were to investigate the feasibility of methylprednisolone rotation as treatment of DIH.
we planned a randomized prospective trial for cancer patients with DIH. The objective of the present study was to determine whether the rotation of corticosteroids affects the incidence and intensity of DIH without compromising the antiemetic efficacy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Methylprednisolone | Experimental | Dexamethasone was replaced with methylprednisolone as an antiemetic. |
|
| Dexamethasone | Active Comparator | Dexamethasone was re-administered in the cycle. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| methylprednisolone | Drug | Adult patients who experienced DIH within 3 days after the administration of dexamethasone as an antiemetic were screened. Eligible patients were randomly assigned to receive dexamethasone or methylprednisolone as an antiemetic (randomization phase). In the next cycle of chemotherapy, the dexamethasone group received methylprednisolone and vice versa in the methylprednisolone group (crossover phase). |
| Measure | Description | Time Frame |
|---|---|---|
| The intensities of hiccups | Clinically assessed every cycles(2-4weeks). The intensities of hiccups were assessed using a NRS. | 2 months |
| Measure | Description | Time Frame |
|---|---|---|
| The intensities of emesis | CLinically assessed every cycles (2-4weeks) The intensities of emesis were assessed using a NRS. | 2 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jung Hun Kang, M.D. | Gyeongsang National University Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gyeongsang National University Hospital | Chiram-dong, Jinju-si | Gyeongsangnam-do | 660-702 | South Korea | ||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28687626 | Derived | Go SI, Koo DH, Kim ST, Song HN, Kim RB, Jang JS, Oh SY, Lee KH, Lee SI, Kim SG, Park LC, Lee SC, Park BB, Ji JH, Yi SY, Lee YG, Yun J, Bruera E, Hwang IG, Kang JH. Antiemetic Corticosteroid Rotation from Dexamethasone to Methylprednisolone to Prevent Dexamethasone-Induced Hiccup in Cancer Patients Treated with Chemotherapy: A Randomized, Single-Blind, Crossover Phase III Trial. Oncologist. 2017 Nov;22(11):1354-1361. doi: 10.1634/theoncologist.2017-0129. Epub 2017 Jul 7. |
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| ID | Term |
|---|---|
| D006606 | Hiccup |
| ID | Term |
|---|---|
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D008775 | Methylprednisolone |
| D008776 | Methylprednisolone Hemisuccinate |
| ID | Term |
|---|---|
| D011239 | Prednisolone |
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
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|
|
| Chungang University Hospital |
| Dongjak-gu |
| Seoul |
| 156-755 |
| South Korea |
| D013256 |
| Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |