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The purpose of the study is to test whether the health care provider access and training in CERTAIN (Checklist for Early Recognition and Treatment of Acute Illness), would facilitate timely and error free best-practice delivery and minimize preventable death and costly complications in critically ill patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Baseline arm | Other | baseline data (50 patients or 3 months per center) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Checklist for Early Recognition and Treatment of Acute Illness (CERTAIN) | Other | This study is about training and implementation of best critical care practices in the international ICUs with variable resources facilitated by access to a specifically designed electronic checklist |
| Measure | Description | Time Frame |
|---|---|---|
| Adherence to best critical care practices | Adherence to best practice in initial evaluation and treatment of critically ill medical and surgical patients Appropriate shock resuscitation Appropriate sepsis treatment Appropriate mechanical ventilation Appropriate peptic ulcer, deep vein thrombosis and infectious disease prophylaxis | Participants will be followed for the duration of ICU stay, an expected average of 2 weeks |
| ICU and hospital lengths of stay | Patient will be followed till they get discharged from hospital for whatever length they stay. | Participants will be followed for the duration of hospital stay, an expected average of 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Mortality for 4 weeks | Patient will be followed for 4 weeks and hospital discharge(up to total 10 weeks post discharge) | Participants will be followed for the duration of 4 weeks and hospital discharge (up to 10 weeks post discharge) |
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Inclusion:
All adult (≥ 18 years) patients admitted for the first time to the participating ICUs will be included.
Exclusion:
Not critically Ill, admitted for low risk monitoring, planned ICU admissions for routine postoperative surveillance for less than 24 hours after uncomplicated surgery, readmission and transferred from outside ICU.
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| Name | Affiliation | Role |
|---|---|---|
| Ognjen Gajic, MD | Mayo Clinic | Principal Investigator |
| Marija Kojicic, MD | Institute for Pulmonary Diseases, Novi Sad, Serbia | Principal Investigator |
| Rahul Kashyap, MD | Mayo Clinic | Study Director |
| Marcus Schultz, MD | University of Amsterdam | Principal Investigator |
| Michelle N Gong, MD | Montefiore Medical Center, New York USA | Principal Investigator |
| Oguz Kilickaya, MD | Gulhane Military Medical Faculty, Ankara, Turkey | Principal Investigator |
| Neill Adhikari, MD | University of Toronto, Toronto Canada | Principal Investigator |
| Linda Bucher, PhD | College of Health Sciences, University of Delavere, Delawere USA | Principal Investigator |
| Daniel Talmor, MD | Beth Israel Deakoness Medical Center, Boston USA | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gomel Regional Clinical Hospital | Homyel | Belarus | ||||
| University Hospital Banja Luka |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41284657 | Derived | Tekin A, Swart P, Flurin L, Vukoja M, Kashyap R, Schultz MJ, Gajic O, Dong Y; CERTAIN investigators of the Society of Critical Care Medicine Discovery Network. The Weekend Effect on Evidence-Based Care Adherence Before and After Implementation of Checklist-Based Care in the Intensive Care Unit: A Multinational Study. J Intensive Care Med. 2026 Jul;41(7):660-669. doi: 10.1177/08850666251396016. Epub 2025 Nov 24. | |
| 33729718 |
| Label | URL |
|---|---|
| education and introduction website | View source |
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|
|
| Yue Dong, MD | Mayo Clinic | Study Director |
| Banja Luka |
| Bosnia and Herzegovina |
| Sveučilišna klinička bolnica | Mostar | Bosnia and Herzegovina |
| Prim.Dr. Abdulah Nakaš | Sarajevo | Bosnia and Herzegovina |
| Hospital Israelita Albert Einstein | São Paulo | Brazil |
| Beijing Hospital | Beijing | China |
| Guang An Men Hospital | Beijing | China |
| China West China Hospital | Chengdu | China |
| 1st Affiliated Hospital of Guangzhou Medical University | Guangzhusi | China |
| Anhui Province Hospital | Hefei | China |
| China Shanghai Changhai Hospital | Shanghai | China |
| Tianjin First Center Hospital | Tianjin | China |
| KBC Rijeka | Rijeka | Croatia |
| Centro De Diagnostica Imagenes Medicina Avanzada y Telemedicina CEDIMAT | Santo Domingo | Dominican Republic |
| Kasturba Hospital | Manial | Karnataka | India |
| Lok Nayak Hospital | New Delhi | National Capital Territory of Delhi | India |
| Ispat General Hospital | Raurkela | Odisha | India |
| St James Hosptial | Dublin | Ireland |
| Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ) | Mexico City | Mexico |
| Central State University Hospital | Ulaanbaatar | Mongolia |
| Shaukat Khanum Memorial Cancer Hospital and Research Center | Lahore | Pakistan |
| St. Luke's Medical Center | Manila | Philippines |
| The Med City Hospital | Manila | Philippines |
| Heliodor Swiecicki Clinical Hospital at the Karol Marcinkowski Medical University in Poznań | Poznan | Poland |
| King Abdulaziz Medical City, | Riyadh | Saudi Arabia |
| Military Medical Academy | Belgrade | Serbia |
| The Institute for pulmonary diseases of Vojvodina | Kamenitz | Serbia |
| Akdeniz University Hospital | Antalya | Turkey (Türkiye) |
| Gulhane Military Medical Faculty | Antalya | Turkey (Türkiye) |
| International hospital Kampala | Kampala | Uganda |
| Derived |
| Vukoja M, Dong Y, Adhikari NKJ, Schultz MJ, Arabi YM, Martin-Loeches I, Hache M, Gavrilovic S, Kashyap R, Gajic O; Checklist for Early Recognition and Treatment of Acute Illness and Injury (CERTAIN) Investigators of the SCCM Discovery Network. Checklist for Early Recognition and Treatment of Acute Illness and Injury: An Exploratory Multicenter International Quality-Improvement Study in the ICUs With Variable Resources. Crit Care Med. 2021 Jun 1;49(6):e598-e612. doi: 10.1097/CCM.0000000000004937. |
| ID | Term |
|---|---|
| D016638 | Critical Illness |
| D018805 | Sepsis |
| D012131 | Respiratory Insufficiency |
| D012769 | Shock |
| D003128 | Coma |
| D006470 | Hemorrhage |
| D014947 | Wounds and Injuries |
| ID | Term |
|---|---|
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D014474 | Unconsciousness |
| D003244 | Consciousness Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
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| ID | Term |
|---|---|
| D057189 | Checklist |
| D001244 | Association |
| ID | Term |
|---|---|
| D003625 | Data Collection |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D013811 | Psychotherapeutic Processes |
| D011613 | Psychotherapy |
| D004191 | Behavioral Disciplines and Activities |
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