Genetic Etiology in Premature Ovarian Insufficiency

Genetic Etiology in Premature Ovarian Insufficiency

Premature Ovarian Insufficiency (POI), first described by Albright in 1942, is defined as an increase in Follicle Stimulating Hormone (FSH), an insufficiency of the ovarian function leading to an early menopause (<40 years of age).Today, only 35% of POI's etiology can be explained. Causes enlightening POI may be enumerated as follows, according to their frequency: genetic mutations, autoimmune defects and abnormalities detected on the X chromosome.The purpose of the study is to determine the frequency of the genetic abnormalities and polymorphisms described above in the POI Turkish population

Inclusion Criteria:

• Clinical diagnosed premature ovarian failure patients
• 20-40 years old female patients

Exclusion Criteria:

• Surgical surgical menopause
• Female patients who can't meet the age range criteria