Effects of Magnesium Sulphate on Sugammadex Reversal of Rocuronium Induced Blockade in Gynaecology Patients

Effects of Magnesium Sulphate on Sugammadex Reversal of Rocuronium Induced Blockade in Gynaecology Patients

Background: The aim of this prospective study was to evaluate the effect of magnesium on the reversal of rocuronium-induced neuromuscular block by sugammadex.

Methods: Eighty patients, aged 18 to 60 years, American Society of Anesthesiologists I-II, undergoing elective gynecological surgery were enrolled. Anaesthesia was induced with propofol and fentanyl and was maintained with 60% nitrous oxide and Oxygen in sevoflurane. The magnesium group received 50 milligram/kilogram (mg/kg) Magnesium intravenous (iv) as a bolus and 15 mg/kg/hour by continuous infusion until the completion of surgery. The placebo group received the equivalent volume of isotonic saline. For intubation, 0.6 mg/kg rocuronium was administered and 0.1 mg/kg was added when Train of four (TOF) counts reached 1 or more during the procedure. At the end of the surgery at a TOF count of 1, 4 mg/kg sugammadex iv was administered. Patients were observed until a TOF ratio of 0.9 was achieved. Patient-controlled analgesia with intravenous morphine was used postoperatively.

Inclusion criteria:

• American Society of Anesthesiologists physical status I or II
• 18-60 years of age
• undergoing elective gynecological surgery
• requiring endotracheal intubation

Exclusion criteria:

• Patients who had body mass index > 35
• gastroesophageal reflux
• a history of allergy
• used medication known to interact with the drugs being used in this trial
• who experienced expected or unexpected difficulty during intubation or ventilation
• had neuromuscular disease
• hepatic or renal insufficiency
• pregnant
• were American Society of Anesthesiologists III or IV
• had a family history of malignant hyperthermia
• detection if low or high control plasma magnesium levels

Inclusion Criteria:

• female patients
• American Society of Anesthesiologists (ASA) physical status I or II
• 18-60 years of age who were undergoing elective gynecological surgery
• requiring endotracheal intubation were enrolled in this prospective study.

Exclusion Criteria:

• Patients who had body mass index > 35
• gastroesophageal reflux
• a history of allergy
• used medication known to interact with the drugs being used in this trial
• who experienced expected or unexpected difficulty during intubation or ventilation
• had neuromuscular disease
• hepatic or renal insufficiency
• were pregnant
• had a family history of malignant hyperthermia
• detection if low or high control plasma magnesium levels