Tissue Banking Study - Polycythemia Vera or Essential Thrombocythemia (PV & ET) Patients

Treatment Strategies for Myeloproliferative Neoplasms by Targeting the Tumor Suppressor P53

The purpose of the study is to isolate and characterize stem cells of patients with Polycythemia Vera (PV) and Essential Thrombocythemia (ET) to find out why these cells are not working the way they should be and why they seem to be sensitive to regulatory factors in the blood, such as clotting.

Specific Aim 1: Assess the effects of RG7112 on MPN HSC/HPC p53 levels and study how it affects MPN stem cell function.

Specific Aim 2. Assess the effects of a combination of low doses of IFNα and RG7112 on MPN HSC/HPC.

Inclusion Criteria:

• polycythemia vera or essential thrombocythemia
• agree to give blood for study

Exclusion Criteria:

• none