The Role of Igf-1 Generation Test in Diagnosis and Treatment of Short Stature

The Role of Igf-1 Generation Test in Diagnosis and Treatment of Short Stature

The purpose of the study is to evaluate the predictive value of IGF-1 generation test for growth velocity during GH treatment for 12 months.

Inclusion Criteria:

• ability to provide written informed consent
• Prepubertal males and females form 5- 11years old
• Bone age <11 years in males and <9 years in females
• Height SD score<-2.25SD in males and females
• IGF-1SD score <-1SD in both males and females
• Peak GH level after stimulation >10ng/ml

Exclusion Criteria:

• History of prior chemotherapy and or radiation
• Active neoplasm
• Pediatric patients with closed epiphyses
• Prader-Willi syndrome, Turner syndrome or any other genetic or chromosomal anomaly
• Treatment with inhaled or systemic steroids
• BMI <5th percentile or >95th percentile
• Tanner 2 at clinical or biochemical examination by ultrasensitive LH and FSH