Probiotics and Recovery From Surgery

Effect of Perioperative Probiotics on Clinical Outcomes of Patients Undergoing Major Abdominal Operation in Community Settings.

The study will investigate whether probiotics given just before and shortly after major abdominal operation improve outcomes.

Perioperative probiotic intervention is associated with approximately 30% reduction of primary outcome measure.

Inclusion Criteria:

• All elective major GI surgical patients

Exclusion Criteria:

• • Current episode of acute pancreatitis as defined by clinician

  • Active medication-induced immunosuppression including systemic corticosteroids, chemotherapy within 4 weeks, immunomodulating agents with transplant indication, biologicals for rheumatoid arthritis and inflammatory bowel disease. Topical chemotherapy or corticosteroids, and chemotherapy applied during operation are allowed.