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Vitreous floaters are tiny, cloudy, clumps of cells that appear in the otherwise clear fluid (vitreous) that fills the back 3/4 of the eye. Floaters are commonly caused by eye conditions such as posterior vitreous detachment (PVD), vitreous syneresis and asteroid hyalosis. While these symptoms are considered physiological in nature, they can be of considerable inconvenience to many patients which affect essential activities. The investigators wish to assess the safety and efficacy of floater treatment in patients with highly symptomatic floaters using an FDA approved nanosecond infrared yttrium aluminum garnet (YAG) lasers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Laser Treated | Active Comparator | Laser will direct the laser at vitreous opacities. The power of the laser will be adjusted from 0.3-12 millijoules (mJ) with the end point being laser induced optical breakdown and the production of a small gas bubble 50% of the time. The treatment will attempt to reduced or eliminate symptomatic floaters in the visual axis. Each treatment session will be limited to 300 laser applications. Participants will be retreated based on continued symptoms for up to 5 sessions |
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| Not Treated | Sham Comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Laser Ablation of Floaters | Procedure |
| ||
| Sham Laser Treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Efficacy of the laser treatment measured by the improvement of visual acuity and floater specific Visual Function Questionnaire (VFQ). | after the last treatment session (approximately 5 days) |
| Measure | Description | Time Frame |
|---|---|---|
| Number of complications in the laser treated eyes compared to the non-treated eyes | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Andrew B Merkur, MD | University of British Columbia | Study Chair |
| Mei Young, MASc | University of British Columbia | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| West Coast Retina Consultants Clinic | Vancouver | British Columbia | V5Z 1K1 | Canada | ||
| Eye Care Centre, Vancouver General Hospital |
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| ID | Term |
|---|---|
| D020255 | Vitreous Detachment |
| C000726608 | vitreous floaters |
| ID | Term |
|---|---|
| D005128 | Eye Diseases |
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Laser will be set at 0.3 millijoules (mJ). There will be a 100% absorptive filter (black spot) of about 1cm placed centrally on the lens. All laser aiming beams will be placed within the 1cm filter. Laser will be applied at 0.3 mJ at the absorptive black spot (100% density filter) in order to create a realistic treatment therapy procedure. |
|
| Vancouver |
| British Columbia |
| V5Z 3N9 |
| Canada |