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The aim of present study is to evaluate the efficacy and safety of Extended-Release Carvedilol Sulfate versus in Patients With Mild or Moderate Primary Hypertension
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Extended-Release Carvedilol Sulfate | Experimental | 18-72mg/d,po |
|
| Sustained-release Metoprolol Succinate | Active Comparator | 47.5-190mg/d,po |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Extended-Release Carvedilol Sulfate | Drug |
| ||
| Sustained-release Metoprolol Succinate |
| Measure | Description | Time Frame |
|---|---|---|
| Mean Change From Baseline in Sitting Diastolic Blood Pressure (sDBP) at Week 8 | Baseline and Week 8 |
| Measure | Description | Time Frame |
|---|---|---|
| Mean Change From Baseline in Sitting Systolic Blood Pressure (sSBP) at Week 8 | Baseline and Week 8 | |
| Proportion of Patients With Sitting Systolic Blood Pressure <140 mm Hg and Sitting Diastolic Blood Pressure <90 mm Hg at Week 8 | Week 8 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yun Zhang, Professor | Contact | 86 135731022060 | yun-zhang@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Yun Zhang, Professor | Qilu Hospital of Shandong University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gansu Provincial Hospital | Recruiting | Lanzhou | Gansu | China | ||
| The Fourth Hospital of Hebei Medical University |
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| Drug |
|
| Recruiting |
| Shijiazhuang |
| Hebei |
| China |
| The Second Xiangya Hospital of Central South University | Recruiting | Changsha | Hunan | China |
| The Second Affiliated Hospital of Soochow University | Recruiting | Suzhou | Jiangsu | China |
| Northern Jiangsu People's Hospital | Recruiting | Yangzhou | Jiangsu | 225001 | China |
| Shengjing Hospital of China Medical University | Recruiting | Shenyang | Liaoning | 110004 | China |
| Qilu Hospital of Shandong University | Recruiting | Jinan | Shandong | 250012 | China |
|
| Taizhou Hospital | Recruiting | Taizhou | Zhejiang | China |
| Xuan Wu hospital affiliated to Capital Medical University | Recruiting | Beijing | 100053 | China |
| Beijing Tongren hospital affiliated to Capital Medical University | Recruiting | Beijing | 11691777 | China |
| Longhua Hospital Shanghai University of Traditional Chinese Medicine | Recruiting | Shanghai | China |
| ID | Term |
|---|---|
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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