A Phase Ⅲ Study of Extended-Release Carvedilol Sulfate for the Treatment of Hypertension

Efficacy and Safety Comparison of Extended-Release Carvedilol Sulfate and Sustained-release Metoprolol Succinate in Patients With Hypertension

The aim of present study is to evaluate the efficacy and safety of Extended-Release Carvedilol Sulfate versus in Patients With Mild or Moderate Primary Hypertension

Inclusion Criteria:

• Males or Females
• Aged from 18 to 70 years
• Had a history of essential hypertension
• Average sitting diastolic blood pressure≧90mmHg，but≦109mmHg

Exclusion Criteria:

• Malignant hypertension
• Average sitting systolic blood pressure≧180mmHg
• Type 2 diabetes with hemoglobin A1c≥9%
• Type 1 diabetes
• New York Heart Association class Ⅱ-Ⅳ congestive heart-failure
• Unstable angina
• Second or third degree heart block or history of sick sinus syndrome unless a pacemaker was in place
• Atrial fibrillation
• Bradycardia (<60 bpm, seated)
• Asthma or other obstructive pulmonary disease
• History of myocardial infarction
• Stroke in the 6 months before screening
• Known contraindications to β-adrenergic blocker therapy
• Glutamic-oxaloacetic transaminase and/or glutamic-pyruvic transaminase>3 times upper limit of normal
• Crea>2 times upper limit of normal
• Pregnancy or lactation