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| Name | Class |
|---|---|
| Hospital Sirio-Libanes | OTHER |
| University of Sao Paulo | OTHER |
| Hospital Israelita Albert Einstein | OTHER |
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The present study aims to evaluate the impact of a weaning strategy based on identification of early signs of respiratory distress by lung ultrasound and the consequent implementation of a "clinical optimization" protocol as compared to usual care.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| usual care | No Intervention | Weaning as protcolised by the units' daily practice (SBT) | |
| Weaning guided by lung ultrasound | Experimental | Predictive early signs of respiratory distress are assessed by lung ultrasound and if found will trigger protocolised intervention (eg- fluid balance,diuretics, thoracocentesis) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| weaning guided by LUS (lung ultrasound) | Other | Predictive early signs of respiratory distress are assessed by lung ultrasound (LUS score >14) and if present will trigger protocolised intervention (eg- fluid balance,diuretics, thoracocentesis, antibiotics when required [CPIS>6], hemglobin>8g/dl triggers transfusion) |
| Measure | Description | Time Frame |
|---|---|---|
| Respiratory distress requiring re-intubation or non-invasive ventilation | 48hours |
| Measure | Description | Time Frame |
|---|---|---|
| 28-day mortality | 28 days | |
| Hospital Mortality | Hospital death/discharge (up to 60 days) | |
| Adverse events |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jorge IF Salluh, MD, PhD | D'Or Institute for Research and Education | Principal Investigator |
| Luiz M Malbouisson, MD, PhD | University of Sao Paulo | Principal Investigator |
| Fabiola Prior, MD | University of Sao Paulo | Principal Investigator |
| Julio Neves, MD | Hospital da Bahia | Principal Investigator |
| Jean-Jacques Rouby, MD | Paris University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| D'OR Institute for Research and Education | Rio de Janeiro | 20230-130 | Brazil |
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Renal dysfunction, complications of thoracocentesis, hydro-electrolite changes, hypotension |
| 48h |