A Study of Trastuzumab Emtansine (Kadcyla) Plus Pertuzumab (Perjeta) Following Anthracyclines in Comparison With Trastuzumab (Herceptin) Plus... | NCT01966471 | Trialant

A Study of Trastuzumab Emtansine (Kadcyla) Plus Pertuzumab (Perjeta) Following Anthracyclines in Comparison With Trastuzumab (Herceptin) Plus... | NCT01966471 | Trialant

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Eligibility Criteria: Inclusion Criteria:

Eastern Cooperative Oncology Group (ECOG) performance status less than or equal to (</=) 1

Non-metastatic histologically confirmed primary invasive breast carcinoma that was operable

HER2-positive breast cancer

Known hormone receptor status of the primary tumor

Adequately excised: participants must have undergone either breast-conserving surgery or mastectomy/nipple- or skin-sparing mastectomy

Pathological tumor-node-metastasis staging (Union for International Cancer Control-American Joint Committee on Cancer [UICC/AJCC] 7th edition): eligible participants must have either:

Node-positive disease (pN more than or equal to [>/=] 1), any tumor size except T0, and any hormonal receptor status; or Node-negative disease (pN0) with pathologic tumor size >2.0 centimeters by standard local assessment and negative for estrogen receptor (ER) and progesterone receptor (PR) determined by a central pathology laboratory

Participants with synchronous bilateral invasive disease are eligible only if both lesions are HER2-positive

No more than 9 weeks (63 days) may elapse between definitive breast surgery (or the last surgery if additional resection required for breast cancer) and randomization

Baseline left ventricular ejection fraction (LVEF) >/=55% measured by echocardiogram (ECHO; preferred) or multiple-gated acquisition (MUGA) scans

Documentation on hepatitis B virus (HBV) and hepatitis C virus (HCV) serology is required

Female participants of childbearing potential must be willing to use one highly effective form of non-hormonal contraception or two effective forms of non-hormonal contraception. For male participants with partners of childbearing potential, one highly effective form of contraception or two effective forms of contraception must be used. Contraception must continue for the duration of study treatment and for 6 months after the last dose of study treatment

Exclusion Criteria:

History of any prior (ipsilateral and/or contralateral) invasive breast carcinoma

History of non-breast malignancies within the 5 years prior to randomization, except for carcinoma in situ (CIS) of the cervix, CIS of the colon, melanoma in situ, and basal cell and squamous cell carcinomas of the skin

Any clinical T4 tumor as defined by tumor-node-metastasis classification in UICC/AJCC 7th edition, including inflammatory breast cancer

For the currently diagnosed breast cancer, any previous systemic anti-cancer treatment (for example, neoadjuvant or adjuvant), including but not limited to, chemotherapy, anti-HER2 therapy (for example, trastuzumab, trastuzumab emtansine, pertuzumab, lapatinib, neratinib, or other tyrosine kinase inhibitors), hormonal therapy, OR anti-cancer radiation therapy (RT) (intra-operative radiotherapy as a boost at the time of primary surgery is acceptable)

Previous therapy with anthracyclines, taxanes, or HER2-targeted therapy for any malignancy

History of DCIS and/or lobular CIS (LCIS) that was treated with any form of systemic chemotherapy, hormonal therapy, or RT to the ipsilateral breast where invasive cancer subsequently developed. Participants who had their DCIS/LCIS treated with surgery only and/or contralateral DCIS treated with radiation are allowed to enter the study

Participants with contraindication to RT while adjuvant RT is clinically indicated

Concurrent anti-cancer treatment in another investigational trial

Cardiopulmonary dysfunction as defined by protocol: angina pectoris requiring anti-anginal medication, serious cardiac arrhythmia not controlled by adequate medication, severe conduction abnormality, or clinically significant valvular disease, significant symptoms (Grade >/=2) relating to left ventricular dysfunction, cardiac arrhythmia, or cardiac ischemia, myocardial infarction within 12 months prior to randomization, uncontrolled hypertension, evidence of transmural infarction on electrocardiogram (ECG), requirement for oxygen therapy

Other concurrent serious diseases that may interfere with planned treatment, including severe pulmonary conditions/illness, uncontrolled infections, uncontrolled diabetes, or known infection with HIV

Any known active liver disease. For participants who are known carriers of HBV/HCV, active hepatitis B/C infection must be ruled out per local guidelines

Inadequate hematologic, renal or liver function

Pregnant or lactating women

Hypersensitivity to any of the study medications or any of the ingredients or excipients of these medications, including hypersensitivity to benzyl alcohol

Chronic immunosuppressive therapies, including systemic corticosteroids

HonorHealth Research Institute - Bisgrove

Scottsdale, Arizona 85258, United States

Kaiser Permanente - Oakland

Oakland, California 94611, United States

Kaiser Permanente - Roseville; Oncology Pharmacy

Roseville, California 95661, United States

Kaiser Permanente - Sacramento; Oncology Pharmacy

Sacramento, California 95814, United States

UC Davis Cancer Center; Oncology

Sacramento, California 95817, United States

Southern California Kaiser Permanente

San Diego, California 92108, United States

Kaiser Permanente - San Jose

San Jose, California 95119, United States

Kaiser Permanente - San Leandro

San Leandro, California 94577, United States

Kaiser Permanente - South SF; Oncology Clinical trials

South San Francisco, California 94080, United States

Stanford University School of Medicine

Stanford, California 94305-5151, United States

Kaiser Permanente - Vallejo

Vallejo, California 94589, United States

Kaiser Permanente - Walnut Creek; Oncology Pharmacy

Walnut Creek, California 94596, United States

Holy Cross Hospital

Fort Lauderdale, Florida 33308, United States

Florida Cancer Specialists; SCRI

Fort Myers, Florida 33901, United States

Florida Cancer Specialists; Saint Petersburg

St. Petersburg, Florida 33719, United States

University Cancer & Blood Center, LLC; Research

Athens, Georgia 30607, United States

Georgia Cancer Specialists

Atlanta, Georgia 30341, United States

Central Georgia Cancer Care PC

Macon, Georgia 31201, United States

Quincy Medical Group; Canc Ctr at Blessing Hosp

Quincy, Illinois 62301, United States

Carle Cancer Center

Urbana, Illinois 61801, United States

Indiana University

Indianapolis, Indiana 46202, United States

Cancer Center of Kansas

Wichita, Kansas 67214-3728, United States

Anne Arundel Health System Research Instit-Annapolis Oncology Ctr

Annapolis, Maryland 21401, United States

Mercy Medical Center

Baltimore, Maryland 21202, United States

Dana Farber Cancer Inst.

Boston, Massachusetts 02115, United States

Beth Israel Deaconess Med Ctr

Boston, Massachusetts 02215, United States

Karmanos Cancer Institute..

Detroit, Michigan 48201, United States

Henry Ford Hospital; Hematology Oncology

Detroit, Michigan 48202, United States

US oncology research at Minnesota Oncology

Saint Paul, Minnesota 55102, United States

Mercy Medical Research Institute

Springfield, Missouri 65807, United States

Dartmouth Hitchcock Med Center

Lebanon, New Hampshire 03756, United States

Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey 08901, United States

Memorial Sloan-Kettering Cancer Center

Commack, New York 11725, United States

ProHEALTH Care Associates LLP

Lake Success, New York 11042, United States

Levine Cancer Institute

Charlotte, North Carolina 28204, United States

Duke University Medical Center

Durham, North Carolina 27710, United States

Cone Health Cancer Center

Greensboro, North Carolina 27403, United States

Oncology Hematology Care Inc

Cincinnati, Ohio 45242, United States

Mercy Clinic Oklahoma Communties, Inc

Oklahoma City, Oklahoma 73120, United States

Magee-Woman's Hospital

Pittsburgh, Pennsylvania 15213, United States

SCRI Tennessee Oncology Chattanooga

Chattanooga, Tennessee 37404, United States

West Clinic

Germantown, Tennessee 38138, United States

Thompson Cancer Survival Center

Knoxville, Tennessee 37916-2305, United States

Sarah Cannon Cancer Center - Tennessee Oncology, Pllc

Nashville, Tennessee 37203, United States

The Center for Cancer and Blood Disorders - Fort Worth

Fort Worth, Texas 76104, United States

Wellmont Medical Associates

Bristol, Virginia 24201, United States

University of Virginia Health System; Hematology/Oncology Division

Charlottesville, Virginia 22908, United States

Virginia Commonwealth University - Massey Cancer Center

Richmond, Virginia 23298, United States

Blue Ridge Cancer Care - Salem

Salem, Virginia 24153, United States

University of Washington

Seattle, Washington 98195, United States

Chris O'Brien Lifehouse

Camperdown, New South Wales 2050, Australia

Calvary Mater Newcastle; Medical Oncology

Waratah, New South Wales 2298, Australia

Haematology & Oncology Clinics of Australia Research Centre

South Brisbane, Queensland 4101, Australia

Burnside War Memorial Hospital, Clinical Trials Centre

Adelaide, South Australia 5056, Australia

Frankston Hospital; Oncology/Haematology

Frankston, Victoria 3199, Australia

Austin Hospital; Medical Oncology

Heidelberg, Victoria 3084, Australia

Epworth HealthCare; Clinical Trials Centre

Richmond, Victoria 3121, Australia

St John of God Murdoch Hospital; Oncology West

Murdoch, Western Australia 6150, Australia

UZ Leuven Gasthuisberg

Leuven, 3000, Belgium

Sint Augustinus Wilrijk, Apotheek

Wilrijk, 2610, Belgium

University Clinical Center of the Republic of Srpska

Banja Luka, 78000, Bosnia and Herzegovina

Clinic of Oncology, University Clinical Center Sarajevo

Sarajevo, 7100, Bosnia and Herzegovina

Hospital Araujo Jorge; Departamento de Ginecologia E Mama

Goiânia, Goiás 74605-070, Brazil

Hospital Sao Lucas - PUCRS

Porto Alegre, Rio Grande do Sul 90610-000, Brazil

Hospital Nossa Senhora da Conceicao

Porto Alegre, Rio Grande do Sul 91350-200, Brazil

Hospital de Cancer de Barretos

Barretos, São Paulo 14784-400, Brazil

Instituto do Cancer do Estado de Sao Paulo - ICESP

São Paulo, São Paulo 01246-000, Brazil

Hospital Sirio Libanes; Centro de Oncologia

São Paulo, São Paulo 01308-050, Brazil

Hospital Perola Byington

São Paulo, São Paulo 01317-000, Brazil

Hospital Paulistano

São Paulo, São Paulo 01321-000, Brazil

Tom Baker Cancer Centre-Calgary

Calgary, Alberta T2N 4N2, Canada

BC Cancer - Kelowna (Sindi Ahluwalia Hawkins Centre)

Kelowna, British Columbia V1Y 5L3, Canada

Lions Gate Hospital

North Vancouver, British Columbia V7L 2L7, Canada

BCCA-Vancouver Cancer Centre

Vancouver, British Columbia V5Z 4E6, Canada

Regional health authority A vitalite health network

Moncton, New Brunswick E1C 8X3, Canada

Queen Elizabeth II Health Sciences Centre; Oncology

Halifax, Nova Scotia B3H 2Y9, Canada

Kingston General Hospital

Kingston, Ontario K7L 2V7, Canada

London Regional Cancer Centre

London, Ontario N6A 4L6, Canada

Credit Valley Hospital/Carlo Fidani Peel Regional Cancer Centre

Mississauga, Ontario L5M 2N1, Canada

Southlake Regional Health Center; Community Care Clinic / Oncology

Newmarket, Ontario L3Y 2P9, Canada

Lakeridge Health Oshawa; Oncology

Oshawa, Ontario L1G 2B9, Canada

Sault Area Hospital

Sault Ste. Marie, Ontario P6B 0A8, Canada

North York General Hospital

Toronto, Ontario M2J 1V1, Canada

Princess Margaret Cancer Center

Toronto, Ontario M5G 1Z5, Canada

Windsor Regional Cancer Centre

Windsor, Ontario N8W 2X3, Canada

Cite de La Sante de Laval; Hemato-Oncologie

Laval, Quebec H7M 3L9, Canada

McGill University; Glen Site; Oncology

Montreal, Quebec H4A 3J1, Canada

Hopital du Saint Sacrement

Québec, Quebec G1S 4L8, Canada

Instituto Oncologico del sur

Temuco, 4810469, Chile

ONCOCENTRO APYS; Oncología

Viña del Mar, 2520598, Chile

Oncomedica S.A.

Montería, 230002, Colombia

Masarykuv onkologicky ustav

Brno, 656 53, Czechia

Fakultni Nemocnice Hradec Kralove; Dept of Radiotherapy & Oncology

Hradec Králové, 500 05, Czechia

MULTISCAN, s.r.o., Radiologicke centrum Pardubice

Pardubice, 532 03, Czechia

Vseobecna fakultni nemocnice v Praze

Prague, 128 08, Czechia

Hospital Diagnostico Escalón

San Salvador, 01101, El Salvador

Ico - Paul Papin

Angers, 49000, France

Clinique Sainte Catherine

Avignon, 84082, France

HOPITAL JEAN MINJOZ; Oncologie

Besançon, 25030, France

Institut Bergonie; Oncologie

Bordeaux, 33076, France

CHU de Brest - Hôpital de Morvan

Brest, 29609, France

Centre Francois Baclesse; Oncologie

Caen, 14076, France

Centre Jean Perrin; Oncologie

Clermont-Ferrand, 63011, France

Centre Georges Francois Leclerc; Oncologie 3

Dijon, 21079, France

Clinique Victor Hugo; Chimiotherapie

Le Mans, 72015, France

Centre Oscar Lambret; Cancerologie Gynecologique

Lille, 59020, France

Centre Leon Berard; Departement Oncologie Medicale

Lyon, 69373, France

Centre D'Oncologie de Gentilly; Oncology

Nancy, 54100, France

Centre Antoine Lacassagne

Nice, 06189, France

Institut de cancerologie du Gard

Nîmes, 30029, France

HOPITAL TENON; Cancerologie Medicale

Paris, 75970, France

Centre Armoricain de Radiotherapie, de Imagerie Medicale et de Oncologie (CARIO)

Plérin, 22190, France

Polyclinique De Courlancy; Centre Radiotherapie Oncologie

Reims, 51057, France

Centre Eugene Marquis; Service d'oncologie

Rennes, 35042, France

Ico Rene Gauducheau; Oncologie

Saint-Herblain, 44805, France

Institut De Cancerologie De La Loire; Consult Oncologie Niveau 0

Saint-Priest-en-Jarez, 42271, France

Institut d'oncologie de l'Orangerie; Chimiotherapie

Strasbourg, 67010, France

Centre Paul Strauss; Oncologie Medicale

Strasbourg, 67065, France

Institut Claudius Regaud; Departement Oncologie Medicale

Toulouse, 31059, France

Centre Alexis Vautrin; Oncologie Medicale

Vandœuvre-lès-Nancy, 54519, France

LTD Institute of Clinical Oncology

Tbilisi, 0159, Georgia

Khechinashvili University Hospital ;Breast Unit

Tbilisi, 0177, Georgia

Chemotherapy and Immunotherapy Clinic Medulla

Tbilisi, 0186, Georgia

Klinikum Augsburg

Augsburg, 86156, Germany

Hochwaldkrankenhaus

Bad Nauheim, 61231, Germany

Frauenarzt-Zentrum Zehlendorf an der Teltower Eiche

Berlin, 14169, Germany

Gemeinschaftspraxis Dr. Bueckner und Dr. Nueckel

Bochum, 44787, Germany

Praxis Dr.med. Katja Ziegler-Löhr

Cologne, 50679, Germany

BAG Freiberg-Richter, Jacobasch, Illmer, Wolf; Gemeinschaftspraxis Hämatologie-Onkologie

Dresden, 01307, Germany

AGAPLESION Markus-Krankenhaus

Frankfurt, 60431, Germany

Städtische Kliniken Frankfurt am Main Höchst

Frankfurt, 65929, Germany

Praxis für Interdisziplinäre Onkologie und Hämatologie GbR

Freiburg im Breisgau, 79110, Germany

Dres.Jochen Wilke und Harald Wagner

Fürth, 90766, Germany

Niels-Stensen-Kliniken Franziskus-Hospital Harderberg GmbH

Georgsmarienhütte, 49124, Germany

Universitätsklinikum Hamburg-Eppendorf; Frauenklinik

Hamburg, 20246, Germany

Gynaekologisch-Onkologische Schwerpunktpraxis Prof. Dr. med. Lueck, Dr. Schrader und Dr. Noeding

Hanover, 30177, Germany

Medizinische Hochschule Hannover, Klinik für Frauenheilkunde und Geburtshilfe

Hanover, 30625, Germany

Klinikum Kulmbach; Frauenklinik

Kulmbach, 95326, Germany

Universitätsklinikum Schleswig-Holstein / Campus Lübeck; Klinik für Frauenheilkunde und Geburtshilfe

Lübeck, 23538, Germany

Klinikum Meiningen Klinik f.Gynäkologie und Geburtshilfe

Meiningen, 98617, Germany

Klinikum der Universität München; Campus Großhadern; Klinik und Poliklinik für Frauenheilkunde

München, 81377, Germany

Hämatologisch/Onkologische Praxis Prof. Dr. Decker, Studienzentrum

Ravensburg, 88212, Germany

Agaplesion Diakonieklinikum Rotenburg

Rotenburg (Wümme), 27356, Germany

Gynäkologie Kompetenzzentrum; Praxis Dr. med. Carsten Hielscher

Stralsund, 18439, Germany

Dres. Helmut Forstbauer, Carsten Ziske und Kollegen; Onkologische Schwerpunktpraxis

Troisdorf, 53840, Germany

GRN-Klinik Weinheim; Abt.Gynäkologie und Geburtshilfe

Weinheim, 69469, Germany

Klinikum Worms; Frauenklinik; Klinik für Gynäkologie und Geburtshilfe

Worms, 67550, Germany

Centro Oncológico Sixtino / Centro Oncológico SA

Guatemala City, 01010, Guatemala

Grupo Angeles

Guatemala City, 01015, Guatemala

Princess Margaret Hospital; Oncology

Hong Kong, Hong Kong

Tuen Mun Hospital; Clinical Oncology

Hong Kong, Hong Kong

Queen Mary Hospital; Dept of Surgery

Pokfulam, Hong Kong

Orszagos Onkologiai Intezet; B Belgyogyaszati Osztaly

Budapest, 1122, Hungary

Municipal Hospital of Uzsoki Utca; Centre of Oncoradiology

Budapest, 1145, Hungary

Debreceni Egyetem, Klinikai Kozpont, Onkologiai Klinika

Debrecen, 4032, Hungary

Szegedi Tudomanyegyetem, AOK, Szent-Gyorgyi Albert Klinikai Kozpont, Onkoterapias Klinika

Szeged, 6720, Hungary

Chaim Sheba Medical Center; Oncology Dept

Ramat Gan, 5262100, Israel

Sourasky / Ichilov Hospital; Oncology Department

Tel Aviv, 64239-06, Israel

Ospedale Antonio Perrino; Oncologia Medica

Brindisi, Apulia 72100, Italy

Istituto Nazionale Tumori Fondazione G. Pascale

Naples, Campania 80131, Italy

Azienda Ospedaliero-Universitaria S.Orsola-Malpighi; Unità Operativa Oncologia Medica

Bologna, Emilia-Romagna 40138, Italy

Irccs Centro Di Riferimento Oncologico (CRO); Dipartimento Di Oncologia Medica

Aviano, Friuli Venezia Giulia 33081, Italy

Policlinico Universitario Campus Biomedico; Uoc Oncologia Medica

Rome, Lazio 00128, Italy

Istituto Nazionale Tumori Regina Elena IRCCS

Rome, Lazio 00144, Italy

ASST DI CREMONA; Unità di Patologia Mammaria Senologia e Breast Unit

Cremona, Lombardy 26100, Italy

Ospedale San Raffaele

Milan, Lombardy 20132, Italy

Irccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 1

Milan, Lombardy 20133, Italy

ASST DI MONZA; Oncologia Medica

Monza, Lombardy 20900, Italy

Istituto Clinico Humanitas;U.O. Oncologia Medica Ed Ematologia

Rozzano, Lombardy 20089, Italy

Humanitas Centro Catanese Di Oncologia; Oncologia Medica

Misterbianco (CT), Sicily 95045, Italy

Ospedale Misericordia E Dolce; Oncologia Medica

Prato, Tuscany 59100, Italy

Azienda Ospedaliera S. Maria - Terni; Oncologia

Terni, Umbria 05100, Italy

IOV - Istituto Oncologico Veneto - IRCCS; Oncologia Medica II

Padova, Veneto 35128, Italy

Aichi Cancer Center Hospital, Breast Oncology

Aichi, 464-8681, Japan

Nagoya City University Hospital; Breast Surgery

Aichi, 467-8602, Japan

Natl Hosp Org Shikoku; Cancer Ctr, Surgery

Ehime, 791-0280, Japan

National Hospital Organization Kyushu Cancer Center;Breast Oncology

Fukuoka, 811-1395, Japan

Gunma University Hospital; Department of Breast and Endocrine Surgery

Gunma, 371-8511, Japan

Gunma Prefectural Cancer Center; Breast Oncology

Gunma, 373-8550, Japan

Hiroshima City Hiroshima Citizens Hospital; Breast Surgery

Hiroshima, 730-8518, Japan

Hiroshima University Hospital; Breast Surgery

Hiroshima, 734-8551, Japan

Hyogo College Of Medicine; Breast And Endocrine Surgery

Hyōgo, 663-8501, Japan

Sagara Hospital; Breast Surgery

Kagoshima, 892-0833, Japan

St. Marianna University School of Medicine Hospital, Breast and Endocrine Surgery

Kanagawa, 216-8511, Japan

Tokai University Hospital, Breast Surgery

Kanagawa, 259-1193, Japan

Kumamoto City Hospital, Breast and Endocrine Surgery

Kumamoto, 862-8505, Japan

Kumamoto Shinto General Hospital; Breast Cancer Center

Kumamoto, 862-8655, Japan

Kyoto University Hospital; Breast Surgery

Kyoto, 606-8507, Japan

Niigata Cancer Ctr Hospital; Breast Surgery

Niigata, 951-8566, Japan

Iwate Med Univ School of Med; Surgery

Numakunai, 028-3695, Japan

Kawasaki Medical School Hospital; Breast and Thyroid Surgery

Okayama, 701-0114, Japan

Naha-nishi Clinic; Surgery

Okinawa, 901-0154, Japan

National Hospital Organization Osaka National Hospital; Breast Surgery

Osaka, 540-0006, Japan

Osaka International Cancer Institute; Breast and Endocrine Surgery

Osaka, 541-8567, Japan

Saitama Medical University International Medical Center; Breast Oncology

Saitama, 350-1298, Japan

Saitama Cancer Center, Breast Oncology

Saitama, 362-0806, Japan

Shizuoka Cancer Center; Breast Surgery

Shizuoka, 411-8777, Japan

Shizuoka General Hospital; Breast Surgery

Shizuoka, 420-8527, Japan

Jichi Medical University; Breast Oncology

Tochigi, 329-0498, Japan

National Cancer Center Hospital; Medical Oncology

Tokyo, 104-0045, Japan

St. Luke's Internat. Hospital, Breast Surgical Oncology

Tokyo, 104-8560, Japan

Tokyo Metropolitan; Komagome Hospital, Surgery

Tokyo, 113-8677, Japan

The Cancer Inst. Hosp. of JFCR; Breast Oncology Center

Tokyo, 135-8550, Japan

Showa University Hospital; Breast Surgery

Tokyo, 142-8666, Japan

Tokyo Medical Uni. Hospital; Breast Oncology

Tokyo, 160-0023, Japan

Instituto Nacional De Cancerologia; Oncology; Tumores Mamarios

Distrito Federal, 14000, Mexico

Fundacion Rodolfo Padilla Padilla A.C.

León, 37000, Mexico

Consultorio de Medicina Especializada; Dentro de Condominio San Francisco

Mexico City, 03100, Mexico

Hospital San Jose Del Tec. de Monterrey; Oncology

Monterrey, 64020, Mexico

Oslo universitetssykehus HF, Ullevål, Kreftsenteret

Oslo, 0450, Norway

Helse Stavanger HF, Stavanger Universitetssjukehus; Klinikk for Blod og kreftsykdommer

Stavanger, 4011, Norway

Centro Hemato Oncologico Panama

Panama City, 0832, Panama

Clinica de Especialidades Medicas

Lima, Lima 41, Peru

Clinica Internacional, Sede San Borja; Unidad de Investigacion de Clínica Internacional

Lima, Lima 41, Peru

Clinica San Borja

Lima, Lima 41, Peru

Instituto Oncologico Miraflore

Miraflores, Lima 18, Peru

San Juan de Dios Hospital;Oncology Unit

Pasay, 1300, Philippines

East Avenue Medical Center

Quezon City, 1100, Philippines

Bialostockie Centrum Onkologii; Oddzial Onkologii Klinicznej

Bialystok, 15-027, Poland

Centrum Onkologii;Im. Franciszka Lukaszczyka;Onkologii

Bydgoszcz, 85-796, Poland

Uniwersyteckie Centrum Kliniczne, Klinika Onkologii i Radioterapii

Gdansk, 80-214, Poland

Szpital Uniwersytecki w Krakowie, Oddział Kliniczny Kliniki Onkologii

Krakow, 30-688, Poland

Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii; Poradnia Chemioterapii

Lodz, 93-513, Poland

Centrum Onkologii Ziemi LUBELSKIEJ im. Sw Jana z Dukli, I oddz. Chemioterapii

Lublin, 20-090, Poland

Europejskie Centrum Zdrowia Otwock Szpital im. Fryderyka Chopina, Klinika Onkologii

Otwock, 05-400, Poland

Narodowy Inst.Onkologii im.Sklodowskiej-Curie Panstw.Inst.Bad; Klinika Nowtw.Piersi i Chir.Rekonstr

Warsaw, 02-781, Poland

Institutul Oncologic Prof. Dr. Al. Trestioreanu Bucuresti

Bucharest, 022328, Romania

Cluj Clinical County Hospital; Oncology Dept

Cluj-Napoca, 400006, Romania

Prof. Dr. I. Chiricuta Institute of Oncology

Cluj-Napoca, 400015, Romania

Regional Institute of Oncology Iasi

Iași, 700483, Romania

Ivanovo Regional Oncology Dispensary

Ivanovo, 153040, Russia

Republican Clinical Oncologic Dispensary of Republic Of Tatarstan

Kazan', 420029, Russia

FSBI Russian Oncology Research Center n.a. Blokhin of MOH RF

Moscow, 115478, Russia

State Inst. Of Healthcare Orenburg Regional Clinical Oncology Dis

Orenburg, 460021, Russia

SBI for HPE "Ryazan State Medical University n.a. I.P. Pavlov" of MoH of RF

Ryazan, 390011, Russia

Scientific Research Institute n.a. N.N. Petrov

Saint Petersburg, 197758, Russia

SBI of Healthcare Samara Regional Clinical Oncology Dispensary

Samara, 443031, Russia

National University Hospital; National University Cancer Institute, Singapore (NCIS)

Singapore, 119228, Singapore

National Cancer Centre; Medical Oncology

Singapore, 169610, Singapore

National Cancer Center; Medical Oncology

Gyeonggi-do, 410-769, South Korea

Ajou Uni Hospital; Medical Oncology

Gyeonggi-do, 443-380, South Korea

Seoul National Uni Hospital; Dept. of Internal Medicine/Hematology/Oncology

Seoul, 03080, South Korea

Severance Hospital, Yonsei University Health System

Seoul, 03722, South Korea

Samsung Medical Centre; Division of Hematology/Oncology

Seoul, 135-710, South Korea

Hospital Universitario de Canarias;servicio de Oncologia

San Cristóbal de La Laguna, Tenerife 38320, Spain

Hospital de Cruces; Servicio de Oncologia

Bilbao, Vizcaya 48903, Spain

Hospital del Mar; Servicio de Oncologia

Barcelona, 08003, Spain

Hospital Univ Vall d'Hebron; Servicio de Oncologia

Barcelona, 08035, Spain

Hospital Duran i Reynals; Oncologia

Barcelona, 08907, Spain

Hospital General Universitario Gregorio Marañon; Servicio de Oncologia

Madrid, 28007, Spain

Centro Oncologico MD Anderson Internacional; Servicio de Oncologia

Madrid, 28033, Spain

Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia

Málaga, 29010, Spain

Hospital Universitario Virgen de Arrixaca; Servicio de Oncologia

Murcia, 30120, Spain

Hospital Clínico Universitario de Valencia; Servicio de Oncología

Valencia, 46010, Spain

Hospital Universitario Miguel Servet; Servicio Oncologia

Zaragoza, 50009, Spain

Sahlgrenska Universitetssjukhuset; Jubileumskliniken

Gothenburg, 413 45, Sweden

Universitetssjukhuset Örebro, Onkologiska kliniken

Örebro, 701 85, Sweden

Akademiska sjukhuset, Onkologkliniken

Uppsala, 751 85, Sweden

Kantonsspital Graubünden Medizin Onkologie; Onkologie und Hämatologie

Chur, 7000, Switzerland

Luzerner Kantonsspital; Medizinische Onkologie

Lucerne, 6004, Switzerland

Brust-Zentrum Zürich AG Seefeldstrasse 214 Zürich

Zurich, 8008, Switzerland

Changhua Christian Hospital; Dept of Surgery

Changhua, 500, Taiwan

Kaohsiung Medical Uni Chung-Ho Hospital; Dept of Surgery

Kaohsiung City, 807, Taiwan

Taichung Veterans General Hospital; Dept of Surgery

Taichung, 407, Taiwan

VETERANS GENERAL HOSPITAL; Department of General Surgery

Taipei, 00112, Taiwan

National Taiwan Uni Hospital; General Surgery

Taipei, 100, Taiwan

Tri-Service General Hospital, Division of General Surgery

Taipei, 114, Taiwan

Chulalongkorn Hospital; Medical Oncology

Bangkok, 10330, Thailand

Faculty of Med. Siriraj Hosp.; Med.-Div. of Med. Oncology

Bangkok, 10700, Thailand

Chiang Rai Prachanukroh Hospital; Department Of Medicine

Chiang Rai, 57000, Thailand

Buddhachinaraj Phitsanulok Hospital; Chemotherapy Unit ; Department of Medicine

Phitsanuok, 65000, Thailand

State Medical Academy; Oncology

Dnipropetrovsk, 43102, Ukraine

Lviv State Oncological Regional Treatment and Diagnostic Center

Lviv, 79031, Ukraine

Velindre Cancer Centre; Oncology Dept

Cardiff, CF14 2TL, United Kingdom

Cheltenham General Hospital; Gloucestershire Oncology Centre

Cheltenham, GL53 7AN, United Kingdom

Royal Cornwall Hospital; Dept of Clinical Oncology

Cornwall, TR1 3LQ, United Kingdom

University Hospital Coventry; InHANSE Unit and Clinical Trials Cancer Treatment Centre

Coventry, CV2 2DX, United Kingdom

Western General Hospital; Edinburgh Breast Unit

Edinburgh, EH4 2XU, United Kingdom

Royal Devon & Exeter Hospital; Oncology Centre

Exeter, EX2 5DW, United Kingdom

Royal Surrey County Hospital; St. Lukes Cancer Centre

Guildford, GU2 7XX, United Kingdom

Leicester Royal Infirmary; Dept. of Medical Oncology

Leicester, LE1 5WW, United Kingdom

Royal Marsden Hospital - Fulham; Oncology Department

London, SW3 6JJ, United Kingdom

Charing Cross Hospital

London, W6 8RF, United Kingdom

Maidstone Hospital; Kent Oncology Centre

Maidstone, ME16 9QQ, United Kingdom

Christie Hospital; Breast Cancer Research Office

Manchester, M20 4QL, United Kingdom

Freeman Hospital; Northern Centre For Cancer Care

New Castle Upon Tyne, NE7 7DN, United Kingdom

Mount Vernon Cancer Centre

Northwood, HA6 2RN, United Kingdom

Nottingham City Hospital; Oncology

Nottingham, NG5 1PB, United Kingdom

Peterborough City Hospital, Edith Cavell Campus; Oncology Department

Peterborough, PE3 9GZ, United Kingdom

Queen Alexandra Hospital; Portsmouth Haematology & Oncology Centre, Level B

Portsmouth, PO6 3LY, United Kingdom

Weston Park Hospital; Cancer Clinical Trials Centre

Sheffield, S10 2SJ, United Kingdom

Musgrove Park Hospital; Department Clinical Research, Beacon Centre

Somerset, TA1 5DA, United Kingdom

Uni Hospital of North Staffordshire; Staffordshire Oncology Centre

Stoke-on-Trent, ST4 6QG, United Kingdom

Royal Marsden Hospital; Dept of Medical Oncology

Sutton, SM2 5PT, United Kingdom

Yeovil District Hospital; Macmillan Cancer Unit

Yeovil, BA21 4AT, United Kingdom