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| ID | Type | Description | Link |
|---|---|---|---|
| 2013-AO1293-42 | Other Identifier | ANSM |
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Severe sepsis and septic shocks are increasingly codified. A biomarker as Lactate is very interesting to detect those situations. Usually, lactate used is arterial but results are often too slow to obtain if we want to respect Surviving Sepsis Campaign guidelines. Some analyzers (EKF diagnostics Lactate Scout*) can give results in 15 seconds.
We hypothesized that capillary lactate, easy to sample, tested with this analyzer may detect earlier those infections states and we want to find the most accurate site to detect severe sepsis (capillary, venous or arterial sample).
Actually, patients presenting a sepsis with arterial lactate> 2 mmol.l-1 must be considered as criticals, and if lactate> 4 mmol.l-1 as septic shock. However, results are usually slow to obtain, especially if we want to respect the Surving Sepsis Campaign, which preconize antibiotic as soon as possible (first hour).
In admission room, arterial sample can't be easily done and usual results need more than 30 minutes. On the contrary, using analyzers like "EKF diagnostics Lactate Scout*" can give results faster with capillary blood (15 seconds). We will compare this results with both veinous and arterial lactate.
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| Measure | Description | Time Frame |
|---|---|---|
| Lactate value | Determine the most accurate value of capillary or venous lactate that may be able to early detect patients with severe sepsis or septic shock, using quick test (EKF diagnostics Lactate scout*). | At admission in emergency department |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison values of capillary lactate and arterial lactate | Determine if capillary blood lactate may replace laboratory reference method (arterial lactate) | 30 minutes after sampling |
| Mortality |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with suspected infection in emergency department (admission time)
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| Name | Affiliation | Role |
|---|---|---|
| Contenti Julie, M.D | Association pour la Formation l'Enseignement et la Recherche du Service de l'Accueil des Urgences | Principal Investigator |
| Jacques Levraut, PD,MD | CHU de Nice, France | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hopital Saint Roch | Nice | Alpes-maritimes | 06000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25432592 | Derived | Contenti J, Corraze H, Lemoel F, Levraut J. Effectiveness of arterial, venous, and capillary blood lactate as a sepsis triage tool in ED patients. Am J Emerg Med. 2015 Feb;33(2):167-72. doi: 10.1016/j.ajem.2014.11.003. |
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| ID | Term |
|---|---|
| D018805 | Sepsis |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
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Determine if capillary lactate value can be use as a mortality predictive tool
| Day 28 mortality |
| D013568 |
| Pathological Conditions, Signs and Symptoms |