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In this prospective, multicenter observational study the investigators capture the perioperative course of peripheral cholinesterase activity. The focus is the perioperative inflammation causing postoperative delirium. Therefore we measure the activity of Acetylcholine-Esterase and Butyrylcholine-Esterase in whole blood of adults in the perioperative context. Early postoperative delirium will be detected by Nu-DESC in the Recovery Room or the Postanaesthesia-Care-Unit. The course of the peripheral cholinesterase activity will be compared with the incidence of postoperative delirium and other clinical dysfunctions.
We follow up the patients for up to five years regarding Delirum, comorbidities and mortality data.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Surgical patients | Adult male and female patients undergoing surgery |
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| Measure | Description | Time Frame |
|---|---|---|
| Postoperative Delirium | Postoperative Delirium (measured by Nursing Delirium Screening Scale) | Participants will be followed in the sample period, an exspected average of three days |
| Measure | Description | Time Frame |
|---|---|---|
| Organ Dysfunctions | Participants will be followed in the sample period, an exspected average of three days | |
| Concomitant medication | Concomitant medications from Anticholinergic Drug Scale (ADS) |
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Inclusion Criteria:
Exclusion Criteria:
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Adult, elective surgery patients of both gender
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| Name | Affiliation | Role |
|---|---|---|
| Claudia Spies, MD | Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin | Berlin | 13353 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30431498 | Result | Muller A, Olbert M, Heymann A, Zahn PK, Plaschke K, von Dossow V, Bitzinger D, Barth E, Meister M, Kranke P, Herrmann C, Wernecke KD, Spies CD. Relevance of peripheral cholinesterase activity on postoperative delirium in adult surgical patients (CESARO): A prospective observational cohort study. Eur J Anaesthesiol. 2019 Feb;36(2):114-122. doi: 10.1097/EJA.0000000000000888. | |
| 34230011 |
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| ID | Term |
|---|---|
| D000071257 | Emergence Delirium |
| ID | Term |
|---|---|
| D003693 | Delirium |
| D003221 | Confusion |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
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| Participants will be followed in the three postoperative days sample period |
| Postoperative Pain | According to Numeric Rating Scale | Participants will be followed in the three postoperative days sample period |
| Duration of Intensive Care Unit Stay | Participants will be followed in the sample period, an exspected average of seven days |
| Duration of Hospital Stay | Participants will be followed in the sample period, an exspected average of four weeks |
| Duration of Mechanical Ventilation | Participants will be followed in the sample period, an exspected average of 168 hours |
| Readmission rate | Participants will be followed in the sample period, an exspected average of four weeks |
| Hospital Treatment Data | Operation time, surgery, anaesthesia | Participations will be followed for the duration of the operation day, an exspected time average of eight hours |
| Postoperative Mortality | Mortality (measured inhouse-mortality according to the patients´records and based on the data record according to §21 Krankenhausentgeltgesetz - (KHEntgG)) | Participants will be followed for the duration of the sample period an exspected average of five years |
| Postoperative Delirium | Postoperative Delirium (measured by Diagnosis of Delirium according to the patients´records and based on the data record according to §21 Krankenhausentgeltgesetz -(KHEntgG)) | Participants will be followed in the sample period, an exspected average of five years |
| Comorbidities | Comorbidities based on the data record according to §21 Krankenhausentgeltgesetz - (KHEntgG) | Participants will be followed in the sample period, an exspected average of five years |
| Department of Anesthesia, Klinik für MIC | Berlin | 14129 | Germany |
| Clinic for Anaesthesiology, Intensive Care Medicine, Palliative Medicine and Pain Medicine, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil | Bochum | 44789 | Germany |
| Department of Anesthesiology, Universitätsklinikum Heidelberg | Heidelberg | 69120 | Germany |
| Department of Anesthesiology, Klinikum Großhadern of the Ludwig Maximilians University of Munich | München | 81377 | Germany |
| Department of Anesthesiology, Universitätsklinikum Regensburg | Regensburg | 93053 | Germany |
| Department of Anesthesiology, Universitätsklinikum Ulm | Ulm | 89081 | Germany |
| Department of anesthesiology and intensive care medicine | Wetzlar | 35578 | Germany |
| Department of Anaesthesia and Critical Care, Universitätsklinikum Würzburg | Würzburg | 97080 | Germany |
| Derived |
| Michels B, Holzamer A, Graf BM, Bredthauer A, Petermichl W, Muller A, Zausig YA, Bitzinger DI. Butyrylcholinesterase as a perioperative complication marker in patients after transcatheter aortic valve implantation: a prospective observational study. BMJ Open. 2021 Jul 6;11(7):e042857. doi: 10.1136/bmjopen-2020-042857. |
| D009422 |
| Nervous System Diseases |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |