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A number of studies have shown that short duration, high intensity interval training can improve health-related outcomes, such as insulin sensitivity and cardiorespiratory fitness. However, these often use specialized equipment, such as cycle ergometers, which makes it difficult to roll these interventions out for wide-scale use in the general population. This study aims evaluate the effects of a high intensity shuttle running intervention on insulin sensitivity, fitness and related cardiometabolic risk factors in men who are currently inactive. Participants will be randomized into intervention (4 weeks of shuttle running) and control groups. We hypothesize that the shuttle running programme will result in improved insulin sensitivity, fitness and increased fat oxidation at rest compared with the control group.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise | Experimental | 4 week supervised high-intensity shuttle running intervention, with 3 sessions per week (12 sessions in total) |
|
| Control | No Intervention | No intervention - participants maintain usual lifestyle |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise | Behavioral | 4-week supervised high intensity shuttle running intervention, 3 sessions per week (12 sessions in total) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Insulin sensitivity | Assessed from glucose and insulin concentrations in fasted state and during oral glucose tolerance test. | Change from baseline immediately post-intervention (4 weeks after baseline) |
| Measure | Description | Time Frame |
|---|---|---|
| Resting substrate utilization | Metabolic rate and fat and carbohydrate oxidation estimated via indirect calorimetry | Change from baseline immediately post-intervention (4 weeks after baseline) |
| Endurance exercise performance |
| Measure | Description | Time Frame |
|---|---|---|
| Objectively measured physical activity | Time spent sedentary and physically active assessed by accelerometer | Change from baseline to week 4 of intervention |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jason Gill, PhD | University of Glasgow | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Glasgow | Glasgow | G12 8QQ | United Kingdom |
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| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D009765 | Obesity |
| D024821 | Metabolic Syndrome |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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Time taken to complete 100 x 10m shuttle runs
| Change from baseline immediately post-intervention (4 weeks after baseline) |
| Sprint exercise performance | Time taken to complete 10 x 10m shuttle runs | Change from baseline immediately post-intervention (4 weeks after baseline) |
| Body weight | Change from baseline immediately post-intervention (4 weeks after baseline) |
| Waist circumference | Change from baseline immediately post-intervention (4 weeks after baseline) |
| Percentage body fat | Change from baseline immediately post-intervention (4 weeks after baseline) |
| Clustered Cardiometabolic Risk Score | Clustered Cardiometabolic Risk Score = -zHDL+zInsulin+zGlucose+zTriglycerides+( zBMI+zWC)/2+(zSBP+zDBP)/2. | Change from baseline immediately post-intervention (4 weeks after baseline) |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |