Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
In patients that require a dental implant, does zirconia compared to titanium, or cad-cam acrylic abutments, provide less inflammation, marginal bone loss or infection during the osseointegration period ?
Place dental Implants and zirconia, titanium, acrylic or cad-cam acrylic abutments, torque to 20 n/cm2 Evaluate Changes in inflammatory levels from T0 (baseline) to T7-12 weeks (measure intermediate points at T0 (baseline),,T1-8 Weeks and T2-12 weeks) Also evaluate outcomes marginal bone loss, gingival height levels and osseointegration
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Zirconia Abutments | Experimental | Place zirconia one-time one-abutment in subcrestal platform-switch dental implants on the day of implant installation, torque 20 n/cm2 |
|
| Titanium Abutments | Experimental | Place titanium one-time one-abutment in subcrestal platform-switch dental implants on the day of implant installation, torque 20 n/cm2 |
|
| Cad-Cam Acrylic abutments | Experimental | Place cad-cam acrylic one-time one-abutment in subcrestal platform-switch dental implants on the day of implant installation, torque 20 n/cm2 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| dental implants | Device | place implant according fabricant guidelines, 2mm sub-crestally |
|
| Measure | Description | Time Frame |
|---|---|---|
| Gingival Inflammatory Changes from baseline to 12 weeks | measure the amount of cytokines and interleukines (interleukin-8 (IL-8), macrophage inflammatory protein-1 (MIP-1 beta), interleukin-1 (IL-1 beta), interleukin-6 (IL-6), matrix metalloproteinase-8 (MMP-8) and matrix metalloproteinase-9 (MMP-9), metallopeptidase inhibitor 1 (TIMP-1), vascular endothelial growth factor (VEGF)), around different implant abutment materials, zirconia,titanium, acrylic, and cad-cam acrylic | Measure - T0 Implant installation T1- 1week post-surgery T2-two weeks T3-3weeks T4-4weeks T5-6weeks T6-8weeks T7-12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Marginal Bone Loss | Parallel periapical standardized radiographs to measure bone position in relation to implant platform, in zirconia,titanium, acrylic, and cad-cam acrylic | measured at 12 weeks post-implant installation |
| Gingival height |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| João Caramês, Phd | Faculdade de Medicina Dentária de Lisboa | Principal Investigator |
| André Chen Chen, Msc | Faculdade de Medicina Dentária de Lisboa | Study Director |
| Elena Cervino, Msc | Implantology Institute | Study Chair |
| Helena Francisco, Phd | Faculdade de Medicina Dentária de Lisboa | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculdade de Medicina Dentária de Lisboa | Lisbon | 1500-662 | Portugal |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
| Zirconia abutments | Device | place zirconia abutment on the day of implant placement |
|
|
| Titanium Abutments | Device | place titanium abutment on the day of implant placement |
|
|
| cad-cam acrylic abutments | Device | place cad-cam acrylic abutment on the day of implant placement |
|
|
| Subcrestal | Procedure | place implant 2mm below crestal bone |
|
| platform-switch | Device | abutment platform is narrow than implant diameter |
|
| one-time one-abutment | Procedure | place the final abutment on the day of surgery and not remove it |
|
|
| Torque 20 n/cm2 | Procedure | the amount of torque applied to the abutment |
|
|
measure with periodontal probe distance from implant platform to the most coronal point of gingival margin mesial, distal, buccal and lingual,in zirconia,titanium, acrylic, and cad-cam acrylic
| 12 weeks post-implant installation |
| Osseointegration | compare survival rate of dental implants rehabilitated with zirconia,titanium, acrylic, and cad-cam acrylic abutments | 12 weeks post-implant installation |
| Height from gingiva to abutment | height from gingival margin to most coronal point of the abutment in zirconia, titanium, acrylic and acrylic cad-cam abutments | 12 weeks post implant installation |
| ID | Term |
|---|---|
| D001851 | Bone Diseases, Metabolic |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
Not provided
Not provided
| ID | Term |
|---|---|
| D015921 | Dental Implants |
| ID | Term |
|---|---|
| D003764 | Dental Materials |
| D001697 | Biomedical and Dental Materials |
| D017266 | Dental Prosthesis |
| D011476 | Prosthodontics |
| D003813 | Dentistry |
| D019736 | Prostheses and Implants |
| D004864 | Equipment and Supplies |
| D008420 | Manufactured Materials |
| D013676 | Technology, Industry, and Agriculture |
Not provided
Not provided