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| ID | Type | Description | Link |
|---|---|---|---|
| GEM-1304 | Other Identifier | Sponsor |
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This is a multi-centric translational study with biological samples collection. The aim of this study is to validate a method to detect BRAFV600 in blood samples.
Samples: Blood from patients with BRAFV600 metastatic melanoma collected following standard medical practice.
The treatment is not the aim of the study. Patients can be treated either with specific or no-specific drug.
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| Measure | Description | Time Frame |
|---|---|---|
| Rate of patient in which BRAF V600 in blood samples is present/absent | two years |
| Measure | Description | Time Frame |
|---|---|---|
| Rate of patients with BRAFV600 present in tumor sample vs blood sample | two years |
| Measure | Description | Time Frame |
|---|---|---|
| BRAF V600 blood levels and illness evolution | two years | |
| NRAS and p61BRAFFV600 serum levels and clinic evolution | two years | |
| BRAFV600 blood levels vs progression-free survival |
Inclusion Criteria:
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Patients with histologically confirmed melanoma and BRAF V600 mutation
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| Name | Affiliation | Role |
|---|---|---|
| María González Cao, MD | Hospital Universitario Quirón Dexeus | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Infanta Cristina | Madrid | Badajoz | 06080 | Spain | ||
| Hospital Germans Trias i Pujol |
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Serum and Plasma
| two years |
| Badalona |
| Barcelona |
| 08916 |
| Spain |
| Hospital del Mar | Barcelona | Barcelona | 08003 | Spain |
| Hospital Universitario Quirón Dexeus | Barcelona | Barcelona | 08028 | Spain |
| Hospital Vall d'Hebron | Barcelona | Barcelona | 08035 | Spain |
| Hospital de la Santa Creu i Sant Pau | Barcelona | Barcelona | 08041 | Spain |
| Hospital Marques de Valdecilla | Santander | Cantabria | 39008 | Spain |
| Hospital Insular de Gran Canaria | Las Palmas de Gran Canaria | Las Palmas | 35001 | Spain |
| Hospital Ramón y Cajal | Madrid | Madrid | 28034 | Spain |
| Hospital Costa del SOl | Marbella | Málaga | 29603 | Spain |
| Hospital Virgen de la Salud | Toledo | Toledo | Spain |
| Fundación Instituto Valenciano de Oncología | Valencia | Valencia | 46009 | Spain |
| Hospital Miguel Servet | Zaragoza | Zaragoza | 50009 | Spain |
| ID | Term |
|---|---|
| D008545 | Melanoma |
| ID | Term |
|---|---|
| D018358 | Neuroendocrine Tumors |
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D009380 | Neoplasms, Nerve Tissue |
| D018326 | Nevi and Melanomas |
| D012878 | Skin Neoplasms |
| D009371 | Neoplasms by Site |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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