in Vivo TICE (TransIntestinal Cholesterol Excretion) | NCT01958216 | Trialant

in Vivo TICE (TransIntestinal Cholesterol Excretion) | NCT01958216 | Trialant

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Trans-intestinal cholesterol excretion in vivo	Other	Measuring trans-intestinal cholesterol excretion in vivo in bile diverted patients	Other: Intravenous injection of deuterated cholesterol diluted in intralipid 20%

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Intravenous injection of deuterated cholesterol diluted in intralipid 20%	Other	At day 0, bile diverted patients will receive an intravenous injection of deuterated cholesterol diluted in intralipid 20%. The plasma, biliary and fecal content of deuterated cholesterol will be measured, by mass spectrometry, at 24, 48 and 72 hours after the initial input.

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Measuring trans-intestinal cholesterol excretion in vivo in bile diverted patients	Measuring trans-intestinal cholesterol excretion in vivo in bile diverted patients	Day 3

Contacts/Locations Module

Central Contacts

Name	Role	Phone	Extension	Email
Bertrand CARIOU, Professor	Contact	+33 (0)2 53 48 27 07		bertrand.cariou@univ-nantes.fr
Cedric LE MAY, Doctor	Contact	+33 (0)2 28 08 01 66		Cedric.Lemay@univ-nantes.fr

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
30342919	Derived	Moreau F, Blanchard C, Perret C, Flet L, Douane F, Frampas E, Mirallie E, Croyal M, Aguesse A, Krempf M, Prieur X, Pichelin M, Cariou B, Le May C. In vivo evidence for transintestinal cholesterol efflux in patients with complete common bile duct obstruction. J Clin Lipidol. 2019 Jan-Feb;13(1):213-217.e1. doi: 10.1016/j.jacl.2018.09.010. Epub 2018 Sep 21.