Metabolomics of Insomnia-Related Hyperarousal

Metabolomics of Insomnia-Related Hyperarousal

Individuals with insomnia have been shown to have higher overall metabolic rates compared to good sleepers, but it is not known which metabolic processes are involved. The goal of this study is to compare a wide array of metabolic processes in 15 people with insomnia and 15 good sleepers. We hypothesize that there will be distinct metabolic processes that are functioning differently in those with insomnia.

Inclusion Criteria:

Criteria for primary insomnia:

• subjective complaint of difficulty initiating or maintaining sleep, waking up too early or nonrestorative sleep
• daytime consequences as a result of the poor sleep
• duration of at least 1 month
• sleep disturbance is not secondary to a medical or psychiatric condition

Criteria for good sleepers:

-subjective report of consistent good sleep

Exclusion Criteria:

• significant medical or psychiatric illness
• diagnosis of a sleep disorder other than insomnia
• women who have been pregnant or lactating in the past 6 months
• non-fluency in spoken or written English
• Current shift work defined as working during the evening or night shift
• Current use of medications that affect sleep
• BMI >27