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The study aims to evaluate the molecular mechanism underlying the erythroid response observed in some patients with myelodysplasia, myelofibrosis and aplastic anemia treated with Deferasirox or Deferoxamina.
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| Measure | Description | Time Frame |
|---|---|---|
| To assess the molecular mechanism underlying the erythroid response | The primary outcome is to evaluate the molecular mechanism underlying the erythroid response (hemogoblin increase and reduction or elimination of trasfusion dependence) observed in some patients with myelodysplasia, myelofibrosis and aplastic anemia treated with Deferasirox or Deferoxamina | 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with diagnosis of Myelodysplasia, myelofibrosis or aplastic anemia undergoing chelation therapy with deferasirox or deferoxamine
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| Name | Affiliation | Role |
|---|---|---|
| Daniela Cilloni, MD | AOU S. Luigi Gonzaga, Regione Gonzole 10, 10043 Orbassano (TO) | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ematologia, AO SS. Antonio e Biagio | Alessandria | AL | 15121 | Italy | ||
| Clinica di Ematologia, AOU Ospedale di Torrette |
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Peripheral blood and bone marrow
| Ancona |
| AN |
| 60020 |
| Italy |
| Ematologia con trapianto, AOU Policlinico di Bari | Bari | BA | 70124 | Italy |
| Istituto di Ematologia e Oncologia Medica, Policlinico S.Orsola | Bologna | BO | 40138 | Italy |
| Ematologia, Spedali Civili | Brescia | BS | 25123 | Italy |
| Struttura complessa di Ematologia, ASO S.Croce e Carle | Cuneo | CN | 12100 | Italy |
| Cattedra di Ematologia Policlino Careggi | Florence | FI | 50134 | Italy |
| Clinica Ematologica, Università di Genova | Genova | GE | 16132 | Italy |
| U.O. Clinica Medicina Interna, IRCCS San Martino IST | Genova | GE | 16132 | Italy |
| UO Ematologia e CTMO, Ospedale Civile G. da Saliceto | Piacenza | PC | 29121 | Italy |
| Ematologia, Università di Padova | Padova | PD | 35128 | Italy |
| Struttura Cattedra di Ematologia e CTMO, AOU di Parma | Parma | PR | 43100 | Italy |
| Ematologia e Centro Trapianti, Centro di Riferimento Oncologico della Basilicata | Rionero in Vulture | PZ | 85028 | Italy |
| Medicina Interna II Divisione di Ematologia, Ospedale S. Luigi Gonzaga | Orbassano | TO | 10043 | Italy |
| Ematologia 2, AOU Città della Salute e della Scienza | Torino | TO | 10126 | Italy |
| S.C.D.U. Ematologia e Terapie cellulari, Ospedale Mauriziano | Torino | TO | 10128 | Italy |
| UOC Ematologia, Ospedale S.Eugenio | Roma | 00144 | Italy |
| Policlinico A.Gemelli | Roma | 00168 | Italy |
| UOC Ematologia, AO S. Giovanni Addolorata | Roma | 00184 | Italy |
| Ematologia, AO S. Andrea | Roma | 00189 | Italy |
| ID | Term |
|---|---|
| D000754 | Anemia, Refractory, with Excess of Blasts |
| D055728 | Primary Myelofibrosis |
| D000741 | Anemia, Aplastic |
| ID | Term |
|---|---|
| D000753 | Anemia, Refractory |
| D000740 | Anemia |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D009190 | Myelodysplastic Syndromes |
| D001855 | Bone Marrow Diseases |
| D009196 | Myeloproliferative Disorders |
| D000080983 | Bone Marrow Failure Disorders |
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