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The aim of the study is to evaluate whether combined therapy with beta-blocker, amiodarone and statine is better than beta-blocker alone for the prevention of atrial fibrillation after coronary by-pass surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| beta blocker and amiodarone | Experimental | The inteventin will be that patients will receive beta blocker Bisoprolol in adjusted dose + Amiodarone per os starting 7 days before coronary by-pass surgery, 200 mg. x 3 tab, followed by 200 mg x 2 tab per os starting on the second postoperative day untill discharge |
|
| beta blocker and statin | Experimental | The intervention will be that patients will receive beta blocker (Bisoprolol tab in adjusted dose)+ Rosuvastatin 20 mg. x 1 starting 7 days before coronary by-pass surgry untill discharge. |
|
| beta blocker | Placebo Comparator | Patients will receive beta blocker (Bisoprolol tab in adjusted dose). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Amiodarone tab 200 mg x 3 | Drug | starting 7 days before coronary by-pass surgery per os 200 mg. x 3 tab, followed by 200 mg x 2 tab per os starting on the second postoperative day untill discharge |
| Measure | Description | Time Frame |
|---|---|---|
| atrial fibrillation | outcome will be number of patients free from atrial fibrillation. | 10 days on average during hospital stay after coronary by-pass surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Enes Osmanovic, Master's degree | Contact | +387 66 725 744 | osmanovic@bhsrce.ba | |
| Goran Imamovic | Contact | goran.imamovic@fmc-ag.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Heart Center BH | Tuzla | TK | 75000 | Bosnia and Herzegovina |
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| ID | Term |
|---|---|
| D000638 | Amiodarone |
| D000068718 | Rosuvastatin Calcium |
| D017298 | Bisoprolol |
| ID | Term |
|---|---|
| D001572 | Benzofurans |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
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|
| rosuvastatin 20 mg tab x1 | Drug | starting 7 days before coronary by-pass surgery |
|
|
| beta blockers Bisoprolol in adjusted dose | Drug | starting 7 days befoe coronary by-pass surgery |
|
|
| D013449 | Sulfonamides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D005464 | Fluorobenzenes |
| D006845 | Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |
| D013450 | Sulfones |
| D013457 | Sulfur Compounds |
| D011743 | Pyrimidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D050198 | Phenoxypropanolamines |
| D011412 | Propanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D020005 | Propanols |
| D000588 | Amines |