Whole-body vibration therapy (WBVT) is a novel, non-pharmacological intervention aimed at improving muscle strength and endurance as well as bone density. It holds promise for children with neuromuscular disorders such as Duchenne muscular dystrophy (DMD) since muscle weakness results not only from muscle breakdown but also physical inactivity and muscle disuse atrophy. Weak DMD patients may increasingly limit their physical activity due to fear of falling or loss of independence (e.g. difficulty rising to stand without assistance). Prolonging the length of time boys with DMD are ambulatory is important for delaying complications of this disease (lung hypoventilation, scoliosis) as well as maintaining bone health. We propose to conduct a pilot study of WBVT in young boys with Duchenne muscular dystrophy (DMD). The primary outcome will be to document safety and feasibility of WBVT in this patient population. The secondary outcomes will evaluate changes in muscle strength and endurance. Bone health will also be examined as part of routine clinical care. The study will include 20 ambulatory boys with DMD; patients will be randomized (1:1 allocation) into 2 groups: WBVT treatment or no WBVT treatment (controls). Treatment groups will consist of 10 boys undergoing daily WBVT in an 8-week, open-label trial.

Post-Study Completion Note: Given competition for enrollment in other DMD trials and burden from daily home WBVT training, it was not feasible to study WBVT in the trial setting, nor is it likely to be a feasible modality for optimizing musculoskeletal health in routine care.

Inclusion Criteria:

1. Diagnosis of Duchenne muscular dystrophy confirmed by at least one of the following:

   • Dystrophin immunofluorescence and/or immunoblot showing complete dystrophin deficiency, and clinical presentation consistent with typical DMD
   • Positive gene deletion test (missing one or more exons) in the central rod domain (exons 25-60) of dystrophin, where reading frame can be predicted as "out-of-frame", and clinical presentation consistent with typical DMD
   • Complete dystrophin gene sequencing showing an alteration (point mutation, duplication, or other mutation resulting in a stop codon mutation) definitively associated with DMD, and clinical presentation consistent with typical DMD

2. Age between 5 - 14 yrs old (inclusive)

3. Positive Gower sign (indicating ability to rise from the floor & presence of proximal muscle weakness).

4. Able to walk 10 meters in <12 seconds

5. Able to stand upon WBVT plate (with knees flexed) for entire treatment protocol (i.e. 15-minutes)

6. Stable absolute dose of glucocorticoids (i.e. prednisone or deflazacort) for at least 3 months prior

7. Stable absolute doses of all medication that may affect muscle function (i.e. coenzyme Q10, green tea extract, creatine, arginine, glutamine, nutritional supplements, etc.) for at least 3 months prior

8. Stable absolute dose of all medication that may affect bone metabolism (i.e. vitamin D and calcium supplementation) for at least 3 months prior

Exclusion Criteria:

1. Clinical presentation, genetic testing and/or muscle biopsy consistent with Becker muscular dystrophy
2. History of recent surgery (within past 6-months)
3. History of a recent fracture (long-bone or vertebral) within past 6-months.
4. Acute inflammatory processes of lower extremities (e.g. cellulitis, etc) due to risk of pain and/or worsening inflammatory process
5. History of venous thrombosis (theoretically risk of inducing thromboembolic event).
6. History of kidney or bladder stones
7. History of uncontrolled seizures or severe migraines
8. History of cardiac arrhythmia
9. Intracranial pathology or hardware (e.g. ventriculoperitoneal shunt, cochlear implant).
10. Use of any investigational or experimental products within last 6-months and/or concomitant participation in another study
11. Inability or refusal to follow the study requirements (e.g. autism, severe cognitive or behaviour problems)
12. Inability or refusal to provide informed consent (parent) and/or assent (child)