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| Name | Class |
|---|---|
| South-Eastern Norway Regional Health Authority | OTHER |
| Norwegian Centre for Ageing and Health | OTHER |
| Leagacy of Josef and Haldis Andresen | UNKNOWN |
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PRODE is a Norwegian multicentre study investigating the prognosis of depression in the elderly. The study has included 169 patients who will be followed with assessments after one and three years.
The study hypothesis is that elderly patients referred to specialist health service have a poor long term prognosis.
Objective: Depression in the elderly is difficult to treat and is often of chronic or recurrent nature. There is little knowledge about the course and the risk factors for recurrence of depression among elderly people in Norway. The aim of the PRODE-study is to examine the short- and long-term prognosis of elderly depressed patients who are referred for treatment in departments of old age psychiatry.
Method: PRODE is a multicentre case-control and longitudinal study of elderly (>60 years) depressed and non-depressed patients with a one and three year follow-up. Nine participating departments of old age psychiatry used the same standardized instruments to collect data of the patients on depression and other mental health issues, cognition, physical health, medications, functions in activities of daily living, quality of life and family carers' situation. The included patients and controls underwent an MRI scan of the brain according to a comprehensive protocol developed for this project. Furthermore, blood and saliva from the included patients are stored in a Biobank for analyses of pro- and anti-inflammatory cytokines and cortisol.
The study included 169 patients (December 2009-January 2013) and will include the same number of non-depressed controls.
Outcome Measures (short-term):
Outcome measures (long-term):
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Depressed patients | Patients admitted to specialist health care service of old age psychiatry |
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| Measure | Description | Time Frame |
|---|---|---|
| Depression | Relapse/recurrence of depression | 1 year after inclusion to the study |
| Depression During Three Years | We have described the course of depression after treatment in departments of old-age psychiatry at specialist healthcare services using assessments at one- and year follow-up. The patients were decribed in the following categories courses: Favourable/less favourable/unfavourable/unclassifiable. | Three years follow-up (mean follow-up time: 1167 days (SD=41) |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Patients With a Diagnosis of Dementia (According to ICD-10) One Year After Inclusion to the Study. | One year after inclusion to the study, there will be a clinical assessment of the patient including a MMSE, if possible, and to evaluate if the patients have dementia. | 1 year after inclusion to the study |
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Inclusion Criteria:
Exclusion Criteria:
- Demented patients with severe aphasia and patients with life threatening diseases will be excluded
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Elderly (>60 years) depressed patients referred to treatment at specialist helth care service in Norway.
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| Name | Affiliation | Role |
|---|---|---|
| Geir Selbaek, MD/Ph.D | Norwegian Centre for Ageing and Health | Study Director |
| Tom Borza, MD/PhD cand | Innlandet Hospital Trust (Sykehuset Innlandet HF) | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Innlandet Hospital Trust | Ottestad | 2315 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39922907 | Result | Bocharova M, Borza T, Watne LO, Engedal K, O'Brien JT, Selbaek G, Idland AV, Hodsoll J, Young AH, Aarsland D. The role of plasma inflammatory markers in late-life depression and conversion to dementia: a 3-year follow-up study. Mol Psychiatry. 2025 Jul;30(7):3029-3038. doi: 10.1038/s41380-025-02908-2. Epub 2025 Feb 8. | |
| 31686490 | Result |
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| ID | Title | Description |
|---|---|---|
| FG000 | Depressed Patients | Patients admitted to specialist health care service of old age psychiatry |
| Title | Milestones | Reasons Not Completed | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Depressed Patients | Patients admitted to specialist health care service of old age psychiatry |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Depression | Relapse/recurrence of depression | Inpatients | Posted | Number | participants | 1 year after inclusion to the study |
|
|
1 year
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Depressed Patients | Patients admitted to specialist health care service of old age psychiatry |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr. PhD Tom Borza | Sykehuset Innlandet | +47 91834607 | tom.borza@sykehuset-innlandet.no |
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| ID | Term |
|---|---|
| D003863 | Depression |
| D003704 | Dementia |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| Solveig and Johan P's Foundation for Psychiatric Research |
| UNKNOWN |
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Apolipoprotein E polymorphism
| Number of Patients With a Diagnosis of Dementia (According to ICD-10) Three Years After Inclusion to the Study. |
3 years after inclusion to the study there was an assessment inluding all available information on cognition; i.e. information from previous follow-ups, clinical or telephone assessment of cognition using Mini Mental Status Examination (MMSE, clinical or telephone-version), and information from next-of-kin or caregivers including the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) and The Clinical Dementia Rating (CDR). Three Senior Consultants with a PhD then used all available information to diagnose dementia according to the ICD-10 classification. |
| 3 years after inclusion to the study (mean time 1167 days, SD 41). |
| Borza T, Engedal K, Bergh S, Selbaek G. Older people with depression - a three-year follow-up. Tidsskr Nor Laegeforen. 2019 Nov 4;139(16). doi: 10.4045/tidsskr.18.0968. Print 2019 Nov 5. English, Norwegian. |
| 28222439 | Result | Borza T, Engedal K, Bergh S, Benth JS, Selbaek G. Trajectories of Depression in Late Life: A 1-Year Follow-Up Study. Dement Geriatr Cogn Disord. 2017;43(3-4):180-192. doi: 10.1159/000458148. Epub 2017 Feb 22. |
| 26242794 | Derived | Borza T, Engedal K, Bergh S, Benth JS, Selbaek G. The course of depression in late life as measured by the Montgomery and Asberg Depression Rating Scale in an observational study of hospitalized patients. BMC Psychiatry. 2015 Aug 5;15:191. doi: 10.1186/s12888-015-0577-8. |
| Participants |
|
| Age, Continuous | Mean | Standard Deviation | years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
|
|
| Secondary | Number of Patients With a Diagnosis of Dementia (According to ICD-10) One Year After Inclusion to the Study. | One year after inclusion to the study, there will be a clinical assessment of the patient including a MMSE, if possible, and to evaluate if the patients have dementia. | Posted | Count of Participants | Participants | 1 year after inclusion to the study |
|
|
|
| Secondary | Number of Patients With a Diagnosis of Dementia (According to ICD-10) Three Years After Inclusion to the Study. | 3 years after inclusion to the study there was an assessment inluding all available information on cognition; i.e. information from previous follow-ups, clinical or telephone assessment of cognition using Mini Mental Status Examination (MMSE, clinical or telephone-version), and information from next-of-kin or caregivers including the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) and The Clinical Dementia Rating (CDR). Three Senior Consultants with a PhD then used all available information to diagnose dementia according to the ICD-10 classification. | Posted | Number | Count of participants | 3 years after inclusion to the study (mean time 1167 days, SD 41). |
|
|
|
| Primary | Depression During Three Years | We have described the course of depression after treatment in departments of old-age psychiatry at specialist healthcare services using assessments at one- and year follow-up. The patients were decribed in the following categories courses: Favourable/less favourable/unfavourable/unclassifiable. | Posted | Number | Counts of participants | Three years follow-up (mean follow-up time: 1167 days (SD=41) |
|
|
|
| 0 |
| 169 |
| 0 |
| 169 |
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| D009422 |
| Nervous System Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| Title | Measurements |
|---|---|
|
| Unclassifiable |
|