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The survival rate (and embryo quality) of donor oocytes with two commercially available devices.
Donor sibling oocytes will be vitrified with two commercially available devices. The first device is closed vitrification with closed storage and the second device is open vitrification with closed storage. Oocyte acceptors receive oocytes from both devices. With the increase in cooling rate generated by the open vitrification (second device), we expect to get an increase in survival rate of 10%. Besides this, embryo quality will be assessed with oocytes obtained from both devices.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| closed vitrification with closed storage | Active Comparator | Half of the oocytes of every donor will be vitrified with the Cryo Bio Systems High Security vitrification (CBSvit HS) device; the standard device in our lab. |
|
| open vitrification with closed storage | Experimental | Half of the oocytes of every donor will be vitrified with the Cryotop closed system (Cryotop SC). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CBSvit HS device | Device | closed vitrification with closed storage |
|
| Measure | Description | Time Frame |
|---|---|---|
| Survival rate | The purpose is to assess the survival rate of donor oocytes with the two vitrification devices. | up to 6 days after every warming cycle |
| Measure | Description | Time Frame |
|---|---|---|
| Embryo development | The purpose is to analyse the pre-implantation development of donor oocytes vitrified with two different devices. | up to 6 days after every warming cycle |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Neelke De Munck, MSc. | Centrum voor Reproductieve Geneeskunde, UZBrussel | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universitair Ziekenhuis Brussel | Jette | Brussels Capital | 1090 | Belgium |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26724798 | Derived | De Munck N, Santos-Ribeiro S, Stoop D, Van de Velde H, Verheyen G. Open versus closed oocyte vitrification in an oocyte donation programme: a prospective randomized sibling oocyte study. Hum Reprod. 2016 Feb;31(2):377-84. doi: 10.1093/humrep/dev321. Epub 2016 Jan 2. |
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| Cryotop SC device | Device | open vitrification with closed storage |
|