Cognitive Impairment Following Cardiac Arrest and Target Temperature Management
Cognitive Impairment Following Cardiac Arrest and Target Temperature Management
This is a steering group approved substudy to the Target Temperature Management trial (TTM, ClinicalTrials.gov Identifier: NCT01020916). TTM compares the effect of two strictly controlled temperature regimes for survivors of out-of-hospital cardiac arrest.
The primary aim of this sub-study is to compare the amount of cognitive impairment in cardiac arrest survivors treated with 33 degrees and 36 degrees and with a matched group of control patients with myocardial infarction.
Our secondary aims are:
Inclusion Criteria:
Exclusion Criteria at time for inclusion in the TTM study:
Known bleeding diathesis
Suspected or confirmed acute intracranial bleeding
Suspected or confirmed stroke
Unwitnessed asystole
Known limitations in therapy and Do Not Resuscitate-order
Known disease making 180 days survival unlikely
Known prearrest status Cerebral Performance Category (CPC)3 or 4
Temperature <30°on admission
Systolic blood pressure <80 mm Hg in spite of fluid loading/vasopressor and/or inotropic medication/intra aortic balloon pump
In-hospital cardiac arrest
OHCA of presumed non-cardiac arrest cause
Additional Exclusion criteria for the sub-study: