The purpose of this study is to evaluate the feasibility of an isotopic technique to identify, and to map the lower-limb drainage nodes during pelvic lymphadenectomy for gynaecological cancers. The diagnostic value of our mapping method will be assessed, and we will determine the incidence of lymhedema.

Pelvic lymphadenectomy is associated with a significant risk of lower-limb lymphedema. In this study, we evaluate the feasibility of identifying the lower-limb drainage nodes (LLDNs) during pelvic lymphadenectomy for gynaecological cancers using an isotopic detection technique with a preoperative radiopharmaceutical injection into both feet Secondary objectives are to map lower-limb drainage, to assess the diagnostic value of our mapping technique, and to determine the incidence of lymphedema. LLDN mapping may allow the preservation of LLDNs, thereby decreasing the risk of lower-limb lymphedema and improving quality of life.

Inclusion Criteria:

• Female patients 18 years of age or older with indication of pelvic lymphadenectomy for gynaecological malignancy:

  • High risk endometrial cancer (stage IB type I grade 3, stage I type II, stage> IB) or with metastatic sentinel lymph node,
  • Early cervical cancer, or with metastatic sentinel lymph node,
  • Ovarian cancer.

• Must provide her signed and informed consent

• Beneficiary of a health insurance

• Having received a medical examination

Exclusion Criteria:

• Contraindication to pelvic lymphadenectomy
• Presence of lymphedema of the lower limbs
• Contraindication to radiomarkers (allergy or hypersensitivity to any component of the biomarker)
• Patient with dementia or altered mental status
• Pregnant or breast feeding patients
• Participation in any other clinical trial that could interfere with the study results