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The aim of this study is to investigate whether RIPC protects the heart against ischemia reperfusion injury on the concentrically hypertrophied myocardium
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| RIPC group | Experimental |
| |
| Control group | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Remote ischemic preconditioning at left upper arm | Procedure | Placement of automated cuff-inflator on the left upper arm after induction of anesthesia RIPCgroup-3 cycles of 5 min ischemia (300 mmHg inflation) & 5 min reperfusion (deflation) |
| Measure | Description | Time Frame |
|---|---|---|
| Serum levels of CK-MB and Tn-T | baseline | |
| Serum levels of CK-MB and Tn-T | 12-hour after surgery | |
| Serum levels of CK-MB and Tn-T | 24-hour after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Myocardial activation of protective signaling pathway | Before commencement of CPB | |
| Myocardial activation of protective signaling pathway | After taking off CPB |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Yonsei University College of Medicine | Seoul | 120-752 | South Korea |
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| Control group | Procedure | keeping the cuff deflated |
|
| ID | Term |
|---|---|
| D017379 | Hypertrophy, Left Ventricular |
| ID | Term |
|---|---|
| D006332 | Cardiomegaly |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D006984 | Hypertrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D035061 | Control Groups |
| ID | Term |
|---|---|
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
| D008722 | Methods |
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