Remote Ischemic Preconditioning Induces Myocardial RISK Signaling Pathway in Patients Undergoing Valvular Heart Surgery

The aim of this study is to investigate whether RIPC protects the heart against ischemia reperfusion injury on the concentrically hypertrophied myocardium

Inclusion Criteria:

• Patients aged ≥20 years with severe degenerative AS presenting concentric remodeling of the LV, who were scheduled for AVR

Exclusion Criteria:

• diabetes mellitus,
• coronary stenosis ≥70%,
• renal failure (serum creatinine > 2.0 mg/dL),
• upper arm peripheral vascular disease,
• LV ejection fraction <50%