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The aim of this study is to assess the role of portal hypertension of peptic ulcer disease in liver cirrhosis and chronic hepatitis.
Retrospective case-control study
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with chronic hepatitis | Patients with chronic hepatitis, who experienced HVPG measurement via transjugular approach and EGD within 3 months of HVPG measurement | ||
| Patients with liver cirrhosis | Patients with liver cirrhosis, who experienced HVPG measurement via transjugular approach and EGD within 3 months of HVPG measurement |
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| Measure | Description | Time Frame |
|---|---|---|
| The Association of HVPG and PUD in Patients With Liver Cirrhosis | The association of hepatic vein pressure gradient that reflects portal hypertension and peptic ulcer disease in patients with liver cirrhosis was assessed statistically. (NO specific time frame, only confined to 2009 to 2012, when the HVPG measurement was done). The Mann-Whitney test was used to evaluate the association between PUD or not and HVPG degree, by SPSS software. | Retrospective case-control study (from 2009 to 2012, up to 3 years) |
| Measure | Description | Time Frame |
|---|---|---|
| The Association Between PUD and HVPG in Patients With Chronic Hepatitis | Retrospective case-control study (from 2009 to 2012, up to 3 years) |
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Inclusion Criteria:
Exclusion Criteria:
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Investigators will analyze the medical records of hepatic vein pressure gradient (HVPG) and esophagogastroduodenoscopy (EGD) cases who had LC or chronic hepatitis in single tertiary hospital of Korea.
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| Name | Affiliation | Role |
|---|---|---|
| Chang Seok Bang, M.D | Department of Internal Medicine, Hallym University College of Medicine | Principal Investigator |
| Gwang Ho Baik, M.D | Department of Internal Medicine, Hallym University College of Internal Medicine | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chuncheon Sacred Heart hospital | Chuncheon | Gangwon-do | 200-704 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 7560857 | Background | Siringo S, Burroughs AK, Bolondi L, Muia A, Di Febo G, Miglioli M, Cavalli G, Barbara L. Peptic ulcer and its course in cirrhosis: an endoscopic and clinical prospective study. J Hepatol. 1995 Jun;22(6):633-41. doi: 10.1016/0168-8278(95)80219-3. | |
| 12169979 | Background | Vergara M, Calvet X, Roque M. Helicobacter pylori is a risk factor for peptic ulcer disease in cirrhotic patients. A meta-analysis. Eur J Gastroenterol Hepatol. 2002 Jul;14(7):717-22. doi: 10.1097/00042737-200207000-00002. |
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800 HVPG measurement cases (Initial). Missing data (3), failure of HVPG measurements (8), cases without EGD (196); including 35 cases of patients on B-blocker, EGD over 3 months from HVPG measurement (79), incomplete EGD due to remnant food materials (19), cases having a history of gastrectomy (5), acute hepatopathy (5), and HCC (30) were excluded.
We analyzed the medical records of 455 hepatic vein pressure gradient (HVPG) and esophagogastroduodenoscopy (EGD) patients who had LC or chronic hepatitis in a single tertiary hospital.
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| ID | Title | Description |
|---|---|---|
| FG000 | Patients With Chronic Hepatitis | Patients with chronic hepatitis, who experienced HVPG measurement via transjugular approach and EGD within 3 months of HVPG measurement |
| FG001 | Patients With Liver Cirrhosis | Patients with liver cirrhosis, who experienced HVPG measurement via transjugular approach and EGD within 3 months of HVPG measurement |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
A total of 127 patients with chronic hepatitis and 328 patients with liver cirrhosis were enrolled.
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| ID | Title | Description |
|---|---|---|
| BG000 | Patients With Chronic Hepatitis | Patients with chronic hepatitis, who experienced HVPG measurement via transjugular approach and EGD within 3 months of HVPG measurement |
| BG001 | Patients With Liver Cirrhosis |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | This is the median age and interquartile range of enrolled patients divided by group (chronic hepatitis vs. liver cirrhosis) |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | The Association of HVPG and PUD in Patients With Liver Cirrhosis | The association of hepatic vein pressure gradient that reflects portal hypertension and peptic ulcer disease in patients with liver cirrhosis was assessed statistically. (NO specific time frame, only confined to 2009 to 2012, when the HVPG measurement was done). The Mann-Whitney test was used to evaluate the association between PUD or not and HVPG degree, by SPSS software. | Posted | Median | Inter-Quartile Range | mmHg | Retrospective case-control study (from 2009 to 2012, up to 3 years) |
|
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Patients With Chronic Hepatitis | Patients with chronic hepatitis, who experienced HVPG measurement via transjugular approach and EGD within 3 months of HVPG measurement |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr. Chang Seok Bang | Hallym University College of Medicine, Chuncheon Sacred Heart Hospital | +82-33-240-5000 | cloudslove@naver.com |
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| ID | Term |
|---|---|
| D005355 | Fibrosis |
| D010437 | Peptic Ulcer |
| D008103 | Liver Cirrhosis |
| D006975 | Hypertension, Portal |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D004378 | Duodenal Diseases |
| D007410 | Intestinal Diseases |
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| 15948813 | Background | Kamalaporn P, Sobhonslidsuk A, Jatchavala J, Atisook K, Rattanasiri S, Pramoolsinsap C. Factors predisposing to peptic ulcer disease in asymptomatic cirrhotic patients. Aliment Pharmacol Ther. 2005 Jun 15;21(12):1459-65. doi: 10.1111/j.1365-2036.2005.02507.x. |
| 24902119 | Derived | Bang CS, Baik GH, Kim JH, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ. Peptic ulcer disease in liver cirrhosis and chronic hepatitis: impact of portal hypertension. Scand J Gastroenterol. 2014 Sep;49(9):1051-7. doi: 10.3109/00365521.2014.923501. Epub 2014 Jun 5. |
Patients with liver cirrhosis, who experienced HVPG measurement via transjugular approach and EGD within 3 months of HVPG measurement
| BG002 | Total | Total of all reporting groups |
| Median |
| Inter-Quartile Range |
| years |
|
| Sex: Female, Male | The number of gender distribution is described in each group here. | Count of Participants | Participants |
|
| HVPG (mmHg) | HVPG (Hepatic vein pressure gradient) was measured in the enrolled population. HVPG reflects portal pressure of patient. To find the relationship between peptic ulcer disease and portal hypertension, the Fisher's exact test was performed. | Median | Inter-Quartile Range | mmHg |
|
| PUD | This is the number of peptic ulcer disease patients in the each group (patients with chronic hepatitis vs. patients with liver cirrhosis) | Number | participants |
|
| Medication (NSAIDs, aspirin, clopidogrel, ticlopidine, steroid) | The number of patients who taking medication in each group is described here. | Number | participants |
|
| smoking | The number of smokers in each group is described here. | Number | participants |
|
| alcoholc | The number of alcoholics in each group is described here. | Number | participants |
|
Patients without PUD in liver cirrhosis, who experienced HVPG measurement via transjugular approach and EGD within 3 months of HVPG measurement |
|
|
| Secondary | The Association Between PUD and HVPG in Patients With Chronic Hepatitis | Posted | Median | Inter-Quartile Range | mmHg | Retrospective case-control study (from 2009 to 2012, up to 3 years) |
|
|
|
| 0 |
| 127 |
| 0 |
| 127 |
| EG001 | Patients With Liver Cirrhosis | Patients with liver cirrhosis, who experienced HVPG measurement via transjugular approach and EGD within 3 months of HVPG measurement | 0 | 328 | 0 | 328 |
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| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D013272 | Stomach Diseases |
| D008107 | Liver Diseases |