Airway inflammation is partly driven by Th17 and Th17-polarizing cytokines that is steroid-resistant. Statins could suppress IL-17 cytokines in other diseases such as atherosclerosis and multiple sclerosis in mouse model. The investigators hypothesize that statins might provide anti-inflammatory benefit of suppressing IL-17 cytokines in COPD patients.

Inclusion Criteria:

• Stable COPD without an exacerbation within 3 months prior to study entry
• mild, moderate and severe COPD with or without treatments, regardless of COPD medications

Exclusion Criteria:

• Concomitant other chronic lung diseases including with TB and malignancy
• HIV
• Being on immunosuppressive drugs and systemic corticosteroids
• Dyslipidemic patients with recent cardiovascular or cerebrovascular disease within 6 month prior to study entry
• Cognitive impairment
• Currently on macrolides, azole anti-fungal agents, amiodarone and amlodipine