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| ID | Type | Description | Link |
|---|---|---|---|
| A120476 | Other Grant/Funding Number | Korean Health Technology R&D Project |
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| Name | Class |
|---|---|
| Ministry of Health & Welfare, Korea | OTHER_GOV |
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This study aims at finding endophenotypes of schizophrenia at neuronal level by obtaining stem cells which is derived from adipose cells of subjects with heavy genetic loading for schizophrenia then differentiating them into neuronal cells.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Genetic High Risk | |||
| Healthy Control |
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| Measure | Description | Time Frame |
|---|---|---|
| Structural and functional characteristics of neurons differentiated from adipose tissue derived stem cells in subjects with genetic high risk for schizophrenia and healthy controls | in vitro measurement of the expression of the neuronal markers for differentiated post-mitotic neuron, GABAergic/Glutamatergic neuron. The neuronal connectivity, neurites from soma and synaptic protein levels will be assessed. In addition, RNA and proteins expression (e.g. Glutamate/GABA receptors) , physiological function, and in vitro response to antipsychotics will be evaluated. | three years |
| Measure | Description | Time Frame |
|---|---|---|
| CAARMS(Comprehensive assessment of at risk mental states) | Clinical rating scale for prodromal symptoms of psychosis. | Baseline |
| PANSS(Positive and Negative Syndrome Scale) | Clinical rating scale for the assessment of symptoms of schizophrenia. |
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Inclusion Criteria:
[Subjects at genetic high risk for schizophrenia]
[Healthy Control]
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jun Soo Kwon, M.D., Ph.D. | Seoul National University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | 110-744 | South Korea |
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| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
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5-10mL of adipose cells in tumescent solution
5-10mL of venous blood
| Baseline |
| Neurocognitive function test battery (composite) | Neurocognitive function battery comprising tests measuring subjects' intelligence, attention, memory, executive function and social cognitive function. | Baseline |
| ERP(event-related potential) profile | ERP profile including P50, P30 & MMN(Mismatch Negativity). | Baseline |
| Structural/resting functional MRI data | Structural/resting functional MRI data | Baseline |
| Proton MR spectroscopy | Molecular neuroimaging data measuring neurochemical composition profile. | Baseline |
| PET imaging data | PET imaging data measuring receptor availability of GABA(gamma-aminobutyric acid) and Glutamate. | Baseline |