The Efficacy and Safety of Topical Papaya (Carica Papaya) Leaf Extract 1% Ointment Versus Mupirocin 2% Ointment in the Treatment of Limited Impetigo: a Randomized, Double-blind, Controlled Clinical Trial

This study will be an investigator-blinded, patient-blinded, assessor-blinded, parallel-group, randomized clinical trial. It aims to evaluate the efficacy of one-week twice-daily application of topical papaya leaf extract ointment compared to mupirocin ointment in achieving clinical cure among patients with impetigo.

Inclusion Criteria:

• Healthy Filipino patients aged 1 year and above with primary impetigo, limited to less than or equal to 1% BSA, and involving only one body area

Exclusion Criteria:

• Extensive impetigo (>1% BSA), affecting more than one body area
• Systemic involvement (lymphadenopathy, fever, sepsis)
• Chronic comorbidities like diabetes mellitus, malignancy, chronic venous insufficiency
• Concurrent immunosuppressive therapy
• Patients ≤ 1 year
• Pregnant & lactating patients