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| ID | Type | Description | Link |
|---|---|---|---|
| W81XWH-12-1-0434 | Other Grant/Funding Number | Telemedicine and Advanced Technology Research Center |
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| Name | Class |
|---|---|
| U.S. Army Medical Research and Development Command | FED |
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After a head injury, many people find that exposure to light causes them increased discomfort. By measuring how the pupil in the eye constricts to flashes of red and blue light, this study will investigate whether this phenomenon is due to a change in the eye's sensitivity to light.
The pupils inside the eyes constrict in response to light stimulation. Different classes of cells within the human retina initiate this response. Recent research suggests that one of the ganglion cell types involved in this pupil response also plays a role in the photophobia experienced by migraine sufferers. The main aim of this study is to determine whether this type of ganglion cell becomes 'hypersensitive' after traumatic brain injury, thereby contributing to symptoms of increased photosensitivity experienced by many of these individuals.
In the first session of this study, subjects will be asked questions about their sensitivity to light and the reaction of their eyes' pupils to flashing red and blue lights will be measured. The subjects will be given a full eye examination to rule out other causes of increased photosensitivity.
In some cases, subjects will be asked to attend a second session roughly two weeks later. They will be asked to wear a watch that measures their daily activity/sleep rhythms and light exposure during this inter-session period. During the second session, further testing of the pupil responses to blue and red flickering light will be performed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Case Subjects |
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| Control Subjects |
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| Measure | Description | Time Frame |
|---|---|---|
| Pupil Responses | The pupil fluctuation evoked by blue and red flickering lights will be measured in patients with a prior brain injury and compared to matched controls. | 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Sleep Rhythms | Daily rhythms of sleep and activity will be assessed in subjects with prior brain injury and compared to matched controls. | 2 weeks |
| Light Exposure | The exposure to red, blue and green components of the light spectrum will be quantified in patients with a prior brain injury, and compared to matched controls. |
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Inclusion Criteria:
Exclusion Criteria:
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Cases: Age 18 or older with symptoms of increased photosensitivity since experiencing a head injury.
Controls: Matched to cases in age, sex and race.
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| Name | Affiliation | Role |
|---|---|---|
| Andrew Hartwick, OD, PhD | Ohio State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| College of Optometry | Columbus | Ohio | 43210 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28009763 | Background | Barker F, Cockerham G, Goodrich G, Hartwick A, Kardon R, Mick AB, Swanson M. Brain Injury Impact on the Eye and Vision. Optom Vis Sci. 2017 Jan;94(1):4-6. doi: 10.1097/OPX.0000000000001001. No abstract available. | |
| 27464575 | Result | Yuhas PT, Shorter PD, McDaniel CE, Earley MJ, Hartwick AT. Blue and Red Light-Evoked Pupil Responses in Photophobic Subjects with TBI. Optom Vis Sci. 2017 Jan;94(1):108-117. doi: 10.1097/OPX.0000000000000934. |
| Label | URL |
|---|---|
| Vision and Traumatic Brain Injury: The Outlook for Therapeutics - ARVO 2016 (Andrew Hartwick, speaker) | View source |
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| ID | Term |
|---|---|
| D006259 | Craniocerebral Trauma |
| D000070642 | Brain Injuries, Traumatic |
| D010787 | Photosensitivity Disorders |
| D020795 | Photophobia |
| ID | Term |
|---|---|
| D020196 | Trauma, Nervous System |
| D009422 | Nervous System Diseases |
| D014947 | Wounds and Injuries |
| D001930 | Brain Injuries |
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| 2 weeks |
| Photosensitivity Symptoms | Subjects will complete survey indicating symptoms they have experienced related to light sensitivity and will grade their discomfort after exposed to brief flashes of light. | Single visit - one day |
| D001927 |
| Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D014786 | Vision Disorders |
| D012678 | Sensation Disorders |
| D009461 | Neurologic Manifestations |
| D005128 | Eye Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |