Effects of rhBNP in Pediatrics After Corrective Repair of Tetralogy Of Fallot

Effects of rhBNP in Pediatrics After Corrective Repair of Tetralogy Of Fallot

The purpose of this study is to determine the effects of rhRNP on urine output and hemodynamics following corrective repair of Tetralogy Of Fallot.

CVP(central venous pressure) and cardiac output are serious index in children with Tetralogy Of Fallot after the corrective repair.The purpose of this study is to investigate if the therapy of rhRNP can improve the survival and life quality after the corrective repair of Tetralogy Of Fallot.

Inclusion Criteria:

• Signed informed consent obtained from patient's legally acceptable representative.
• Pediatric patients after Repair of Tetralogy Of Fallot.

Exclusion Criteria:

• Psychotic, addictive or other disorder limiting the ability to provide informed consent or to comply with study requirements.
• Treatment or planned treatment with another investigational drug within 3 months of screening.
• Known hypersensitivity to bosentan or any of the excipients
• cardiogenic shock and inclination of hypotension（SBP< 60mmHg）.