Variation of Aortic Compliance Related to Exercise Training With or Without Supervised Sessions

ClinicalTrials.gov ID

NCT01939080

Lead Sponsor

University Hospital Center of MartiniqueOTHER

Overall Status

Unknown status

Study Type

Interventional

Phase

Not Applicable

Enrollment

308Estimated

Last Update Posted

Aug 18, 2016Estimated

Start Date

Apr 2013

Primary Completion Date

Jun 2017Estimated

Completion Date

Aug 2018Estimated

Official Title

Exercise Training in Patients With Cardiovascular Risk: Predictability of Aortic Compliance Normalization

Brief Summary

Many conditions and cardiovascular diseases (including stroke) are better managed with regular exercise training. The expected effects are partial reversal of adverse effects on heart and blood vessel structure and function, improved glycemic, tension and weight control.

Physiologically, the aorta maintains low left ventricular after-load, promotes optimal sub-endocardial coronary blood flow, and transforms pulsatile into laminar blood flow. Increased aortic stiffness may ultimately contribute to left ventricular dysfunction. Regular exercise training is likely to decrease the pulse wave velocity (a measure of the aortic compliance). Some subjects seem more responsive than others, and they may not expect the same benefit of exercise training. To the best of our knowledge, this has not been explained yet.

• Cardiovascular Disease

• Exercise training with supervised sessions

Ages Eligible for Study

Adult (18-64)Older Adult (65+)

Sexes Eligible for Study

All

Accepts Healthy Volunteers

No

Eligibility Criteria

Inclusion Criteria:

• patients aged 50-69 years, with moderate or high cardiovascular risk

Exclusion Criteria:

• any physical or medical problem liable to limit the patient' ability to perform the cardiopulmonary exercise testing or the exercise training in safe conditions.

Primary Purpose

Supportive Care

Allocation

Randomized

Interventional Model

Parallel Assignment

Masking

None (Open Label)

Lead Sponsor

University Hospital Center of MartiniqueOTHER

Armelle.Jean-Etienne@chu-fortdefrance.fr

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