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This study aimed to assess the systemic absorption and disposition of tobramycin in patients treated with a tobramycin-laden bone graft substitute (Osteoset® T).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| adult patients treated with Osteoset® T (tobramycin sulfate) | 10 g or 20 g of Osteoset® T |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tobramycin | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of systemic tobramycin concentration | Develop a population pharmacokinetic model for tobramycin in patients treated with an active calcium sulfate bone substitute and to predict tobramycin systemic exposure under various dose and renal function levels. | within 10 days after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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All adult patients treated with Osteoset® T in our orthopedic surgery department
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24593819 | Derived | Livio F, Wahl P, Csajka C, Gautier E, Buclin T. Tobramycin exposure from active calcium sulfate bone graft substitute. BMC Pharmacol Toxicol. 2014 Mar 4;15:12. doi: 10.1186/2050-6511-15-12. |
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| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| ID | Term |
|---|---|
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| ID | Term |
|---|---|
| D014031 | Tobramycin |
| ID | Term |
|---|---|
| D009328 | Nebramycin |
| D007612 | Kanamycin |
| D000617 | Aminoglycosides |
| D006027 | Glycosides |
| D002241 |
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| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| Carbohydrates |