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Magnesium sulphate is given to the patients during the colorectal cancer surgery under the hypothesis that it would attenuate the postoperative hypercoagulability. The investigators intend to characterize the changes of coagulation in colorectal cancer patients by using the point-of-care device after the infusion of magnesium sulphate.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Magnesium | Experimental | Magnesium sulfate infusion during a operation period. Infusion regimen:
|
|
| Control | Placebo Comparator | administration of normal saline as a same volume of magnesium sulphate as a same method. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Magnesium Sulfate | Drug |
| ||
| Normal saline |
| Measure | Description | Time Frame |
|---|---|---|
| Change of maximum clot firmness (MCF) of FIBTEM | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day | |
| Change of Clotting time (CT) of INTEM | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day | |
| Change of Clot firmness time (CFT) of INTEM | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day | |
| Change of Alpha angle of INTEM | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day | |
| Change of MCF of INTEM | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day | |
| Change of CT of EXTEM | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day | |
| Change of CFT of EXTEM | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day | |
| Change of Alpha angle of EXTEM | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day | |
| Change of MCF of EXTEM | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day |
| Measure | Description | Time Frame |
|---|---|---|
| Change of Hemoglobin | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day | |
| Change of Platelet count | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Bundang Hospital | Seongnam-si | Gyeonggi-do | 463-707 | South Korea |
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| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
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| ID | Term |
|---|---|
| D008278 | Magnesium Sulfate |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D017616 | Magnesium Compounds |
| D007287 | Inorganic Chemicals |
| D013431 | Sulfates |
| D013464 | Sulfuric Acids |
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|
| Change of International normalized ratio of prothrombin time | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day |
| Change of Activated partial thrombin time | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day |
| Change of Fibrinogen | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
| D013456 |
| Sulfur Acids |
| D013457 | Sulfur Compounds |
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |