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Exercise has been shown to be beneficial for the brain. The investigators would like to test this specifically for those diagnosed with Alzheimer's disease. This study will involve 30 randomized patients to take part in the out-patient exercise program and 30 patients to continue with their regular activities over a 6-month period. Once that period is over, half of the 30 patients who participated in the outpatient exercise program will continue in the program and the other half will be randomized to independently continue to exercise. The investigators hypothesize that exercising will benefit the patient by slowing the dementia process, improving behavioral symptoms, and decreasing volume loss of certain brain regions. Each person will perform personalized exercise regimens, MR imaging and neuropsychological tests will be used to measure the benefits of exercise. Ultimately, the hope is that the results of this study could be used to facilitate exercise programs for patients. Enrollment is completely voluntary and all personal data obtained will remain confidential.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal Activity level | No Intervention | ||
| Personalized Exercise Regimen | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Personalized Exercise Regimen | Other | All exercise regimens include a stationary bicycle. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Neuropsychological Test Battery | The test battery selected comprises of standardized, validated tests focusing on domains including: attention & concentration, executive functioning, learning and memory, visuospatial, language and semantic memory, pre-morbid intellectual functioning, and speed of processing. | Throughout first 6 months of patient participation |
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Inclusion criteria for patients will be as follows:
Inclusion criteria for the caregivers will be as follows:
Exclusion criteria for Patients and Caregivers:
Exclusion Criteria for Patients:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Carmela Tartaglia, MD, FRCPC | Contact | 416-603-5483 | carmela.tartaglia@uhn.ca |
| Name | Affiliation | Role |
|---|---|---|
| Carmela Tartaglia, MD, FRCPC | Cognitive Neurologist at the Toronto Western Hospital Memory Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Toronto Western Hospital, WW5-449 | Recruiting | Toronto | Ontario | M5T 2S8 | Canada |
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| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| D003704 | Dementia |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D024801 | Tauopathies |
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| D019636 |
| Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |