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| ID | Type | Description | Link |
|---|---|---|---|
| 00012377 | Other Identifier | DIMDI-Nr. |
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The investigators will compare myocard vitality diagnostics using 2D-Strain echography and MRI.
Each patient with typical angina pectoris symptoms will get echocardiographic examination during the inclusion phase. If motion disorder of regional left ventricular myocardial wall is detected, patient will get coronary angiography (not study related, caused of typical angina pectoris symptoms and high probability of CHD). If coronary stenosis related to motion disorder is available, patient will be randomized in two groups during coronary angiography.
In addition, as part of a feasibility analysis, the possibility of a consolidation of data of coronary angiography with the ultrasound images will be researched by first group of patients. The aim is to simplify the visualization of the intraprocedural vitality detection. For this purpose, a position sensor based on electromagnetic fields (EMT) will be used during coronary angiography.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MRI-Arm | Active Comparator | Myocardial vitality determination based on MRI diagnostics. |
|
| Echo-Arm | Experimental | Myocardial vitality determination using echocardiography in combination with 2D-Strain Analysis. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cardiac ultrasound | Device | Patient will get echocardiographic examination during coronary angiography. 2D-Strain Analysis will be performed based on data of these echocardiographic examination. Only when vitality in the contraction impaired segments will be established based on 2D-Strain Analysis, PCI will be performed. |
| Measure | Description | Time Frame |
|---|---|---|
| State of health score | State of health score will be determinated by all patients for the evaluation of clinical outcomes (using the standardized questionnaire on state of health (SF-36))6 months after clinical diagnostics. | 6 month after diagnistics |
| Measure | Description | Time Frame |
|---|---|---|
| Left ventricular function (ejection function) | Left ventricular function (ejection function) by all patients will be determinated 6 month after diagnostics. | 6 month after diagnistics |
| End-diastolic and end-systolic volume. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Michael Becker, MD | University Hospital, Aachen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Aachen | Aachen | North Rhine-Westphalia | 52074 | Germany |
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| ID | Term |
|---|---|
| D000787 | Angina Pectoris |
| D023921 | Coronary Stenosis |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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|
| MRI scanner | Device | Coronary angiography on patient will be canceled. Patients will get viability assessment using MRI within the next 7 days. When vitality will be established with MRI, patient will get PCI. |
|
End-diastolic and end-systolic volume will be determined by all patients 6 month after diagnostics
| 6 month after diagnostics |
| Capture of Major Adverse Cardiac and Cerebrovascular Events(MACCE) | It will be determined, whether all patients suffered any major adverse cardiac and cerebrovascular events (MACCE) inter alia stroke, myocardial infarction, death 18 month after diagnostics | 18 month after diagnostics |
| D002637 |
| Chest Pain |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D003327 | Coronary Disease |