Drug-Drug Interaction Study With PF-05089771

Evaluation Of The Effect Of PF-05089771 On The Metabolism Of Multiple Cytochrome P450 And OATP1B1 Transporter Substrates

This study will test the potential for PF-05089771 to interact with a cocktail of drugs

Inclusion Criteria:

• Healthy male and/or female subjects between the ages of 18 and 55 years;
• Body Mass Index (BMI) of 17.5 to 30.5 kg/m2; and a total body weight >50 kg (110 lbs);

Exclusion Criteria:

• Any condition possibly affecting drug absorption
• History of regular alcohol consumption
• Screening supine blood pressure >140 mm Hg (systolic) or >90 mm Hg (diastolic),
• Consumption of coffee, cola or other caffeine containing drinks