Pharmacokinetic Properties of Nalmefene in Subjects With Renal Impairment and in Healthy Subjects

An Interventional, Single-site, Open-label, Four-group, Single-dose Study Investigating the Pharmacokinetic Properties of Nalmefene in Subjects With Renal Impairment (Mild, Moderate, or Severe) and in Healthy Subjects

To investigate if renal impairment will have an impact on the pharmacokinetics of nalmefene

Inclusion Criteria:

• Healthy young subjects and subjects with renal impairment with a Glomerular Filtration Rate (GFR) of 50-80 ml/min/1.73m2, 30-<50 ml/min/1.73m2, <30 ml/min/1.73m2 will be included in the study.
• The subjects must have a BMI between 19 and 32 kg/m2.

Exclusion Criteria:

• The subject has a history of renal transplant or is undergoing dialyse treatment.
• The subject is, in the opinion of the investigator, unlikely to comply with the protocol or is unsuitable for any reason.

Other inclusion and exclusion criteria may apply.