Methylphenidate for Attention Problems After Pediatric TBI

Efficacy of Methylphenidate for Management of Long-Term Attention Problems After Pediatric Traumatic Brain Injury (TBI)

Traumatic Brain Injury (TBI) - methylphenidate treatment

The objectives of the study are to (1) determine the efficacy and dose-response of methylphenidate treatment of attention problems after pediatric traumatic brain injury (TBI) and (2) provide a better understanding of the relationship of a prior history of attention deficit hyperactivity disorder (ADHD), ADHD subtypes after TBI, executive function, and attentional control to treatment efficacy. The proposed clinical trial will enroll 50 children, age 6-17 years, with attention problems >6 months after moderate to severe TBI into a randomized, double-blind, placebo-controlled, cross-over design trial with 3 dose conditions (low, medium, and high).

Inclusion Criteria:

• Between ages of 6-17
• Sustained Moderate to Severe TBI
• TBI occurred at least 6 months prior to beginning the study
• TBI occurred no earlier than 5 years of age
• Positive endorsement of 6 out of 9 items on the Vanderbilt ADHD inattention or hyperactivity scale

Exclusion Criteria:

• History of developmental disability or mental retardation
• Current active participation in ADHD-related behavioral intervention
• History of psychiatric condition requiring an inpatient admission in past 12 months
• Actively taking medications with a contraindication to Concerta that cannot be discontinued
• Current use of stimulant medication or ADHD specific medications that cannot be discontinued
• Non-blunt head injury
• Family history of arrhythmia
• Pregnancy