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| Name | Class |
|---|---|
| Norwegian University of Science and Technology | OTHER |
| Karolinska University Hospital | OTHER |
| University Hospital of North Norway | OTHER |
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Even at centers with very large experience, the risk of cerebrospinal fluid (CSF) leakage in surgery for microvascular decompression is reported up to 3%.
Prevention of leakage is important since meningitis may follow. Also, leakage usually means longer hospital stay and increased cost.
In case of detected leakage extra sutures may be applied, placement of a lumbar drain may be considered or a revision and improved closure may be attempted. With leakage in the subcutaneous tissue, but not through the skin, a local accumulation causing local symptoms may also occur. In addition to being burdensome and being associated with longer hospital stays with possible revision surgery, such complications are also very costly. The best way to reduce cost and burden, and to improve patient care, is to prevent CSF leakage.
The aim of this study is to determine if prophylactic lumbar tap is beneficial for prevention of cerebrospinal fluid leakage following microvascular decompression, by comparison of surgical approaches in 3 geographical areas in the Scandinavian health system.
Hypothesis: There is no difference in cerebrospinal fluid leakage between the group subject to prophylactic spinal tap versus the group without prophylactic spinal tap.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| prophylactic spinal tap | Microvascular decompression surgery approach at the Karolinska University Hospital, i.e. a small craniectomy (removal of bone without putting it back), and postoperatively serial prophylactic lumbar tap |
| |
| no prophylactic spinal tap | Microvascular decompression surgery approach at St Olavs Hospital Trondheim University Hospital and the University Hospital of North Norway, i.e. not comprising a policy of preventing CSF leak by performing prophylactic lumbar taps or its equivalents |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| prophylactic spinal tap | Procedure |
| ||
| no prophylactic spinal tap |
| Measure | Description | Time Frame |
|---|---|---|
| cerebrospinal fluid leakage | Any leakage after 3rd postoperative day (since one hospital introduces iatrogenic leakage the first 3 days after surgery) | 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| overall complication risk | 30 days | |
| Specific complication risk | risks associated with prophylactic treatment: meningitis, positional head-ache (need for epidural blood-patch) | 30 days |
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Inclusion Criteria:
Exclusion Criteria:
-
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The planned study is a retrospective review of medical charts in consecutive patients undergoing surgery for neurovascular conflict by microvascular decompression surgery. Patients will be identified from the operating protocols at the respective hospitals.
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| Name | Affiliation | Role |
|---|---|---|
| Asgeir S Jakola, MD PhD | St. Olavs Hospital | Study Chair |
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| ID | Term |
|---|---|
| D003389 | Cranial Nerve Diseases |
| D005156 | Facial Neuralgia |
| D014277 | Trigeminal Neuralgia |
| D019569 | Hemifacial Spasm |
| D065634 | Cerebrospinal Fluid Leak |
| D011183 | Postoperative Complications |
| ID | Term |
|---|---|
| D009422 | Nervous System Diseases |
| D005155 | Facial Nerve Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| Procedure |
|
| days in hospital | 30 days |
| D020433 |
| Trigeminal Nerve Diseases |
| D013035 | Spasm |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006259 | Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
| D010335 | Pathologic Processes |