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This multicenter prospective study will evaluate the safety and efficacy of Avastin (bevacizumab) in routine clinical practice in patients with advanced/metastatic epithelial ovarian cancer, fallopian tube cancer or primary peritoneal cancer. Data will be collected from eligible patients until death, withdrawal of consent, loss to follow-up, or study closure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cohort | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bevacizumab | Drug | Participants will receive five cycles of bevacizumab 15 mg/kg concurrently with six cycles of the standard chemotherapy every three weeks (q3w), followed by extended cycles of bevacizumab 15 mg/kg q3w as a single agent for additional 16 cycles. A total of 21 cycles of bevacizumab will be administered in this study. |
| Measure | Description | Time Frame |
|---|---|---|
| Safety: Incidence of adverse events | up to approximately 1.5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Progression-free survival | up to approximately 1.5 years | |
| Overall survival | up to approximately 1.5 years | |
| Overall response rate (complete response + partial response) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Clinical Trials | Hoffmann-La Roche | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Manipal Hospital | Bangalore | Karnataka | 560017 | India | ||
| HealthCare Global Enterprises Limited |
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| Label | URL |
|---|---|
| Clinical Trials Registry - India | View source |
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|
|
| up to approximately 1.5 years |
| Clinical benefit rate (complete response + partial response + stable disease) | up to approximately 1.5 years |
| Banglore |
| Karnataka |
| 560027 |
| India |
| Marthwada Regional Cancer Center & Research Institute | Aurangabad | Maharashtra | 431001 | India |
| MOC Cancer Care & Research Centre | Mumbai | Maharashtra | 400056 | India |
| HCG NCHRI Cancer Center | Nagpur | Maharashtra | 440026 | India |
| HCG Manavata Cancer Centre | Nashik | Maharashtra | 422002 | India |
| Apex Wellness Hospital | Nashik | Maharashtra | 422009 | India |
| Grant Medical Foundation, Ruby Hall Clinic | Pune | Maharashtra | 411001 | India |
| Jehangir Clinical Development Centre Pvt. Ltd | Pune | Maharashtra | 411001 | India |
| Sahyadri Speciality Hospital | Pune | Maharashtra | 411004 | India |
| Rajiv Gandhi Cancer Inst.&Research Center | New Delhi | National Capital Territory of Delhi | 110085 | India |
| Peerless Hospitex Hospital and Research Center Ltd. | Kolkata | West Bengal | 700094 | India |
| MAX Balaji Hospital | Delhi | 110092 | India |
| ID | Term |
|---|---|
| D010051 | Ovarian Neoplasms |
| D010534 | Peritoneal Neoplasms |
| D005185 | Fallopian Tube Neoplasms |
| ID | Term |
|---|---|
| D004701 | Endocrine Gland Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D010049 | Ovarian Diseases |
| D000291 | Adnexal Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D005833 | Genital Neoplasms, Female |
| D014565 | Urogenital Neoplasms |
| D000091662 | Genital Diseases |
| D004700 | Endocrine System Diseases |
| D006058 | Gonadal Disorders |
| D000008 | Abdominal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D004066 | Digestive System Diseases |
| D010532 | Peritoneal Diseases |
| D005184 | Fallopian Tube Diseases |
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| ID | Term |
|---|---|
| D000068258 | Bevacizumab |
| ID | Term |
|---|---|
| D061067 | Antibodies, Monoclonal, Humanized |
| D000911 | Antibodies, Monoclonal |
| D000906 | Antibodies |
| D007136 | Immunoglobulins |
| D007162 | Immunoproteins |
| D001798 | Blood Proteins |
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
| D012712 | Serum Globulins |
| D005916 | Globulins |
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