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This is a registry study in adults with spasticity to determine onabotulinumtoxinA use in clinical practice. Treatment will be administered in accordance with physician standard practice. All treatment decisions lie with the physician.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| onabotulinumtoxinA | onabotulinumtoxinA administered according to physician standard of care. All treatment decisions lie with the physician. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| onabotulinumtoxinA | Drug | onabotulinumtoxinA administered according to physician standard of care. All treatment decisions lie with the physician. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of Patients Reporting Satisfaction with Treatment | 5 Weeks | |
| Percentage of Health Care Providers Reporting Satisfaction with Treatment | 12 Weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Physical Functioning on a 5-Point Scale | 5 Weeks | |
| Severity of Pain on an 11-Point Scale | 5 Weeks | |
| Disability Assessment on a 4-Point Scale |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with Muscle Spasticity
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| Name | Affiliation | Role |
|---|---|---|
| Aleks Zuzek | Allergan | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Loma Linda University School Of Medicine | Loma Linda | California | 92350 | United States | ||
| MS Center of California |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41025675 | Derived | Wissel J, List C, Schwartz M, Nelson M, Musacchio T, Duarte E. Relief of pain associated with spasticity in adult patients after treatment with onabotulinumtoxinA: Post hoc observational results from the ASPIRE study. PM R. 2026 Apr;18(4):410-425. doi: 10.1002/pmrj.70013. Epub 2025 Sep 30. | |
| 38813838 | Derived |
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|
| 12 Weeks |
| Newport Beach |
| California |
| 92663 |
| United States |
| Sutter Health General Hospital | Sacramento | California | 95816 | United States |
| Design Neuroscience Center | Doral | Florida | 33172 | United States |
| Brooks Rehabilitation Hospital | Jacksonville | Florida | 32216 | United States |
| Emerald Coast Center for Neurological Disorders | Pensacola | Florida | 32514 | United States |
| Gil, Ramon A. | Port Charlotte | Florida | 33952 | United States |
| Kernan Hospital | Baltimore | Maryland | 21207 | United States |
| MedTechnical, PLLC | Silver Spring | Maryland | 20910 | United States |
| Michigan Institute for Neurological Disorders | Farmington Hills | Michigan | 48334 | United States |
| The Curators of the University of Missouri on behalf of University of Missouri Health Care | Columbia | Missouri | 65212 | United States |
| Seacoast Physiatry | Exeter | New Hampshire | 03833 | United States |
| CentraState Medical Center | Freehold | New Jersey | 07728 | United States |
| Guilford Neurologic Associates | Greensboro | North Carolina | 27405 | United States |
| Dayton Center for Neurological Disorders | Dayton | Ohio | 45459 | United States |
| Albert Einstein Healthcare Network, Moss Rehabilitation Hospital | Elkins Park | Pennsylvania | 19027 | United States |
| Penn State Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | United States |
| Penn Medicine Rittenhouse | Philadelphia | Pennsylvania | 19146 | United States |
| University of Pittsburgh Medical Center Health System | Pittsburgh | Pennsylvania | 15213 | United States |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | United States |
| Metrolina Neurological Assoc., PA | Rock Hill | South Carolina | 29732 | United States |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | United States |
| Memorial Hermann Hospital | Houston | Texas | 77030 | United States |
| Scott & White Memorial Hospital | Temple | Texas | 76508 | United States |
| Swedish Neuroscience Institute | Seattle | Washington | 98122 | United States |
| Center for Neurological Disorders, S.C. | Milwaukee | Wisconsin | 53215 | United States |
| Hôpital Morvan | Brest | Finistere | 239609 | France |
| Pôle Saint Helier | Rennes | Ille Et Vilaine | 35043 | France |
| CHU de Grenoble - Hôpital Sud | Échirolles | Isere | 38434 | France |
| Hopital Saint Philibert - GHICL Lille | Lomme | Nord | 59160 | France |
| Centre Hospitalier de Pau | Pau | Pyrenees Atlantiques | 64046 | France |
| Universitaetsklinikum Freiburg | Freiburg im Breisgau | Baden-Wurttemberg | 79106 | Germany |
| Medizinische Hochschule Hannover | Hanover | Lower Saxony | 30625 | Germany |
| Universitaetsklinikum Muenster | Münster | North Rhine-Westphalia | 48149 | Germany |
| Universitaetsklinikum Leipzig AoeR | Leipzig | Saxony | 04103 | Germany |
| Universitaetsklinikum Jena | Jena | Thuringia | 07740 | Germany |
| Parkinson Klinik Wolfach GmbH & Co KG | Baden Wuerttemberg | 77709 | Germany |
| Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari | Bari | 70124 | Italy |
| Ospedale San Raffaele | Milan | 20132 | Italy |
| Azienda Ospedaliero - Universitaria Maggiore delle Carità | Novara | 28100 | Italy |
| Policlinico Universitario Agostino Gemelli | Roma | 00168 | Italy |
| Hospital Universitario Mutua de Terrassa | Terrassa | Barcelona | 08221 | Spain |
| Hospital Universitario Marques de Valdecilla | Santander | Cantabria | 39008 | Spain |
| Hospital de Conxo (Santiago de Compostela) GALICIA | Santiago de Compestela | Pontevedra | 15706 | Spain |
| Hospital del Mar | Barcelona | 08003 | Spain |
| Vall d'Hebron Institut de Recerca-VHIR | Barcelona | 08035 | Spain |
| Hospital Clinic i Provincial de Barcelona | Barcelona | 08036 | Spain |
| Complejo Hospitalario de Pontevedra | Pontevedra | 36071 | Spain |
| Taipei Medical University Hospital | Taipei | 110 | Taiwan |
| Chang Gung Memorial Hospital, Linkou | Taoyuan County | 333 | Taiwan |
| The National Hospital for Neurology & Neurosurgery | London | Greater London | WC1N 3BG | United Kingdom |
| Birch Hill Hospital | Rochdale | Greater Manchester | OL12 9QB | United Kingdom |
| Kent and Canterbury Hospital | Kent | Kent | CT1 3NG | United Kingdom |
| The Walton Centre | Liverpool | Merseyside | L9 7LI | United Kingdom |
| Nottingham University Hospitals City Campus | Nottingham | Nottinghamshire | NG5 1PB | United Kingdom |
| Bavikatte G, Francisco GE, Jost WH, Baricich A, Duarte E, Tang SFT, Schwartz M, Nelson M, Musacchio T, Esquenazi A. Pain, disability, and quality of life in participants after concurrent onabotulinumtoxinA treatment of upper and lower limb spasticity: Observational results from the ASPIRE study. PM R. 2024 Nov;16(11):1175-1189. doi: 10.1002/pmrj.13195. Epub 2024 May 30. |
| 38206635 | Derived | Bavikatte G, Esquenazi A, Dimyan MA, Dashtipour K, Feng W, Mayadev A, Fanning K, Musacchio T, Zuzek A, Francisco GE. Safety and Real-World Dosing of OnabotulinumtoxinA for the Treatment of Adult Spasticity: Post Hoc Analysis of the Adult Spasticity International Registry Study. Am J Phys Med Rehabil. 2024 Jul 1;103(7):580-587. doi: 10.1097/PHM.0000000000002410. Epub 2024 Jan 8. |
| 34245684 | Derived | Esquenazi A, Francisco GE, Feng W, Baricich A, Gallien P, Fanning K, Zuzek A, Bandari DS, Wittenberg GF. Real-World Adherence to OnabotulinumtoxinA Treatment for Spasticity: Insights From the ASPIRE Study. Arch Phys Med Rehabil. 2021 Nov;102(11):2172-2184.e6. doi: 10.1016/j.apmr.2021.06.008. Epub 2021 Jul 7. |
| 33151636 | Derived | Esquenazi A, Bavikatte G, Bandari DS, Jost WH, Munin MC, Tang SFT, Largent J, Adams AM, Zuzek A, Francisco GE. Long-Term Observational Results from the ASPIRE Study: OnabotulinumtoxinA Treatment for Adult Lower Limb Spasticity. PM R. 2021 Oct;13(10):1079-1093. doi: 10.1002/pmrj.12517. Epub 2021 Jan 11. |
| 31953896 | Derived | Francisco GE, Jost WH, Bavikatte G, Bandari DS, Tang SFT, Munin MC, Largent J, Adams AM, Zuzek A, Esquenazi A. Individualized OnabotulinumtoxinA Treatment for Upper Limb Spasticity Resulted in High Clinician- and Patient-Reported Satisfaction: Long-Term Observational Results from the ASPIRE Study. PM R. 2020 Nov;12(11):1120-1133. doi: 10.1002/pmrj.12328. Epub 2020 Feb 27. |
| ID | Term |
|---|---|
| D009128 | Muscle Spasticity |
| ID | Term |
|---|---|
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D009122 | Muscle Hypertonia |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D019274 | Botulinum Toxins, Type A |
| ID | Term |
|---|---|
| D001905 | Botulinum Toxins |
| D008666 | Metalloendopeptidases |
| D010450 | Endopeptidases |
| D010447 | Peptide Hydrolases |
| D006867 | Hydrolases |
| D004798 | Enzymes |
| D045762 | Enzymes and Coenzymes |
| D045726 | Metalloproteases |
| D001426 | Bacterial Proteins |
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
| D001427 | Bacterial Toxins |
| D014118 | Toxins, Biological |
| D001685 | Biological Factors |
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