Compare 24-hour intragastric pH and therapeutic effectiveness of proton pump inhibitor (PPI) among different administration methods: per oral (PO), intravenous (IV), and sublingual (SL).

Intragastric pH and therapeutic effectiveness of PPI was compared among patients given PPI with different administration methods. 24 hour intragastric pH catheter was inserted in stomach of patients with peptic ulcer an hour prior to PPI administration in order to observe the initial change in pH. Three groups of patients were given PPI through per oral, intravenous, and sublingual administration methods. The hypothesis of this study is that sublingual administration will be faster than oral or IV administration in PPI dosing with respect to intragastric pH change and re-bleeding rate.

Inclusion Criteria:

• Patients with peptic ulcer disease
• Age: 20-75 years old
• Patients who submitted informed consent

Exclusion Criteria:

• Peptic ulcer disease with spurting and oozing
• Shock, hypotension, pregnancy
• Gastrointestinal malignancy

3 groups, each group with 20 subject with peptic ulcer ages between 20 to 75