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| Name | Class |
|---|---|
| German Federal Ministry of Education and Research | OTHER_GOV |
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The purpose of this study is to investigate the effect of micellar curcumin on inflammation and lipid metabolism markers in subjects at risk for the metabolic syndrome.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Micellar curcumin | Experimental | Subjects receive three times per day four capsules of curcumin micelles. One capsule contains 20 mg of curcumin. At the beginning, after three and six weeks of intake, blood samples are collected. |
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| Placebo | Placebo Comparator | Subjects receive three times per day four capsules of placebo preparation. At the beginning, after three and six weeks of intake, blood samples are collected. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Micellar curcumin | Dietary Supplement | 80 mg micellar curcumin (oral) three times a day for six weeks |
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| Measure | Description | Time Frame |
|---|---|---|
| C-reactive protein (CRP) | Serum CRP in mg/L | At baseline and 6 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma curcumin concentrations | Concentrations (in nmol/L) of curcumin and curcumin conjugates in plasma | At baseline and 6 weeks |
| Serum alanine transaminase activity | Serum activity of ALT in U/L |
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Inclusion criteria:
Exclusion criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jan Frank, Ph.D. | University of Hohenheim | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of Biological Chemistry and Nutrition, University of Hohenheim | Stuttgart | Baden-Wurttemberg | 70599 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26909743 | Result | Kocher A, Bohnert L, Schiborr C, Frank J. Highly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidemic individuals. Mol Nutr Food Res. 2016 Jul;60(7):1555-63. doi: 10.1002/mnfr.201501034. Epub 2016 May 23. |
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| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| Placebo | Dietary Supplement | Only the excipients (without curcumin) used to prepare the curcumin micelles are given as placebo. |
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| At baseline and 6 weeks |
| Fasting blood glucose | Fasting blood glucose in mmol/L | At baseline and 6 weeks |
| Plasma tumor necrosis factor alpha | Plasma concentrations of TNFα in pg/mL | At baseline and 6 weeks |
| Serum uric acid | Serum concentrations of uric acid in g/L | At baseline and 6 weeks |
| Plasma albumin | Plasma concentrations of albumin in g/L | At baseline and 6 weeks |
| Serum total cholesterol | Serum total cholesterol in mmol/L | At baseline and 6 weeks |
| Serum triacylglycerols | Serum triacylglycerols in mmol/L | At baseline and 6 weeks |
| Serum HDL cholesterol | Serum HDL cholesterol in mmol/L | At baseline and 6 weeks |
| Serum LDL cholesterol | Serum LDL cholesterol in mmol/L | At baseline and 6 weeks |
| Serum aspartate transaminase activity | Serum activity of AST in U/L | At baseline and 6 weeks |
| Serum gamma glutamyl transferase activity | Serum activity of gamma-GT in U/L | At baseline and 6 weeks |
| Serum alkaline phosphatase activity | Serum activity of ALP in U/L | At baseline and 6 weeks |
| Serum bilirubin | Serum concentrations of bilirubin in g/L | At baseline and 6 weeks |
| Plasma interleukine 6 | Plasma concentrations of IL-6 in pg/mL | At baseline and 6 weeks |
| Serum insulin | Serum concentrations of insulin in pg/mL | At baseline and 6 weeks |
| Body weight | Body weight in kg | At baseline and 6 weeks |
| Diastolic blood pressure | Diastolic blood pressure in mmHg | At baseline and 6 weeks |
| Serum creatinine | Serum concentrations of creatinine in g/L | At baseline and 6 weeks |
| Systolic blood pressure | Systolic blood pressure in mmHg | At baseline and 6 weeks |
| D009750 |
| Nutritional and Metabolic Diseases |