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It has been reported that deep extubation can reduce cardiopulmonary complication against endotracheal tube extubation during emergence from general anesthesia. The investigators hypothesized that using desflurane with target controlled infusion of remifentanil is more effective than using desflurane alone during deep extubation. The purpose of this study is to evaluate the effect of remifentanil to prevent respiratory complication (etc. coughing) during emergence from general anesthesia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Desflurane group | Active Comparator | 1.5 MAC desflurane until extubation |
|
| Desflurane with remifentanil group | Active Comparator | 1.0 MAC desflurane with 1.0ng/ml targeted concentration infusion of remifentanil |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Desflurane with remifentanil | Drug | During the emergence from anesthesia,extubation was performed under 1.0 MAC desflurane with 1.0ng/ml remifentanil |
|
| Measure | Description | Time Frame |
|---|---|---|
| Awakening Time | The outcomes assessor will record from the time of extubation in operating room to the time of eye opening and mouth opening | Participants will be followed from the time of extubation in operating room to the time of discharge from recovery room, an expected average of 1day. |
| Measure | Description | Time Frame |
|---|---|---|
| Success Rate & Complication Rate Including Cough | We will assess the success rate of deep extubation without complication and the occurrence of cough during emergence from general anesthesia. | assessing the success rate of deep extubation without complication and the occurrance of cough from the completion of surgery to 5minute after extubation. |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative Pain | The outcomes assessor will evaluate the degree of postoperative pain using a numeric rating scale (NRS). (0 = no pain, 10 = unimaginable severe pain) | Participants will be followed for the duration of postanesthesia care unit (PACU) stay, an expected average of 1 hour. |
Inclusion Criteria:
Exclusion Criteria:
Dropout criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chung-Ang University Hospital | Seoul | 156-755 | South Korea |
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| ID | Title | Description |
|---|---|---|
| FG000 | Desflurane Group | 1.5 MAC desflurane until extubation Desflurane: During the emergence from anesthesia,extubation was performed under 1.5 MAC desflurane |
| FG001 | Desflurane With Remifentanil Group |
| Title | Milestones | Reasons Not Completed | |||||
|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| Desflurane | Drug | During the emergence from anesthesia,extubation was performed under 1.5 MAC desflurane |
|
|
1.0 MAC desflurane with 1.0ng/ml targeted concentration infusion of remifentanil
Desflurane with remifentanil: During the emergence from anesthesia,extubation was performed under 1.0 MAC desflurane with 1.0ng/ml remifentanil
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| ID | Title | Description |
|---|---|---|
| BG000 | Desflurane Group | 1.5 MAC desflurane until extubation Desflurane: During the emergence from anesthesia,extubation was performed under 1.5 MAC desflurane |
| BG001 | Desflurane With Remifentanil Group | 1.0 MAC desflurane with 1.0ng/ml targeted concentration infusion of remifentanil Desflurane with remifentanil: During the emergence from anesthesia,extubation was performed under 1.0 MAC desflurane with 1.0ng/ml remifentanil |
| BG002 | Total | Total of all reporting groups |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean | Standard Deviation | years |
| |||||||||||||||
| Sex: Female, Male | Count of Participants | Participants |
|
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Awakening Time | The outcomes assessor will record from the time of extubation in operating room to the time of eye opening and mouth opening | Posted | Median | Inter-Quartile Range | minutes | Participants will be followed from the time of extubation in operating room to the time of discharge from recovery room, an expected average of 1day. |
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| Secondary | Success Rate & Complication Rate Including Cough | We will assess the success rate of deep extubation without complication and the occurrence of cough during emergence from general anesthesia. | Not Posted | assessing the success rate of deep extubation without complication and the occurrance of cough from the completion of surgery to 5minute after extubation. | |||||||||||||||||||||||||||||||||||
| Other Pre-specified | Postoperative Pain | The outcomes assessor will evaluate the degree of postoperative pain using a numeric rating scale (NRS). (0 = no pain, 10 = unimaginable severe pain) | Not Posted | Participants will be followed for the duration of postanesthesia care unit (PACU) stay, an expected average of 1 hour. |
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Desflurane Group | 1.5 MAC desflurane until extubation Desflurane: During the emergence from anesthesia,extubation was performed under 1.5 MAC desflurane | 0 | 31 | 0 | 31 | ||
| EG001 | Desflurane With Remifentanil Group | 1.0 MAC desflurane with 1.0ng/ml targeted concentration infusion of remifentanil Desflurane with remifentanil: During the emergence from anesthesia,extubation was performed under 1.0 MAC desflurane with 1.0ng/ml remifentanil | 0 | 31 | 0 | 31 |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr. Chong Wha Baek | Chung-Ang University Hospital | 82-2-6299-2579 | nbjhwa@naver.com |
| ID | Term |
|---|---|
| D000077335 | Desflurane |
| D000077208 | Remifentanil |
| ID | Term |
|---|---|
| D005019 | Ethyl Ethers |
| D004987 | Ethers |
| D009930 | Organic Chemicals |
| D008738 | Methyl Ethers |
| D006845 | Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |
| D011422 | Propionates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Male |
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