Reverse Electrical Remodeling of Native Conduction in Cardiac Resynchronization Therapy

Study of Reverse Electrical Remodeling of Native Conduction in Cardiac Resynchronization Therapy

Cardiac resynchronization therapy with pacemaker alone, or in combination with a cardioverter-defibrillator, prolongs life and decreases risk of heart failure exacerbation in patients with low ejection fraction and wide QRS. Some patients achieve decrease in QRS duration 6 months after cardiac resynchronization therapy. Such phenomenon is called reverse electrical remodeling of native conduction. Retrospective analysis showed that reverse electrical remodeling of the native conduction after at least 6 months of CRT is associated with decreased rate of ventricular arrhythmias and better survival. This study is designed to study reverse electrical remodeling prospectively.

Inclusion Criteria:

• patients undergoing implantation of a CRT-D

Exclusion Criteria:

• age < 18 y
• pregnancy or planned pregnancy